{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:39:01Z","timestamp":1783247941103,"version":"3.54.6"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Project of Hunan Provincial Science and Technology Innovation","award":["no. 2020SK1013"],"award-info":[{"award-number":["no. 2020SK1013"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["no. 82070356"],"award-info":[{"award-number":["no. 82070356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["no. 2021JJ30033"],"award-info":[{"award-number":["no. 2021JJ30033"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["no. 2021JJ40870"],"award-info":[{"award-number":["no. 2021JJ40870"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["no.2022ZZTS0863"],"award-info":[{"award-number":["no.2022ZZTS0863"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the clinic. Aging plays an essential role in the occurrence and development of AF. Herein, we aimed to identify the aging-related genes associated with AF using bioinformatics analysis. Transcriptome profiles of AF were obtained from the GEO database. Differential expression analysis was performed to identify AF-specific aging-related genes. GO and KEGG enrichment analyses were performed. Subsequently, the LASSO, SVM-RFE, and MCC algorithms were applied to screen aging-related genes. The mRNA expression of the screened genes was validated in the left atrial samples of aged rapid atrial pacing-induced AF canine models and their counterparts. The ROC curves of them were drawn to evaluate their diagnostic potential. Moreover, CIBERSORT was used to estimate immune infiltration. A correlation analysis between screened aging-related genes and infiltrating immune cells was performed. A total of 24 aging-related genes were identified, which were found to be mainly involved in the FoxO signaling pathway, PI3K-Akt signaling pathway, longevity regulating pathway, and peroxisome according to functional enrichment analysis. LASSO, SVM-RFE, and MCC algorithms identified three genes (<jats:italic>HSPA9<\/jats:italic>, <jats:italic>SOD2<\/jats:italic>, <jats:italic>TXN<\/jats:italic>). Furthermore, the expression levels of <jats:italic>HSPA9<\/jats:italic> and <jats:italic>SOD2<\/jats:italic> were validated in aged rapid atrial pacing-induced AF canine models. <jats:italic>HSPA9<\/jats:italic> and <jats:italic>SOD2<\/jats:italic> could be potential diagnostic biomarkers for AF, as evidenced by the ROC curves. Immune infiltration and correlation analysis revealed that <jats:italic>HSPA9<\/jats:italic> and <jats:italic>SOD2<\/jats:italic> were related to immune cell infiltrates. Collectively, these findings provide novel insights into the potential aging-related genes associated with AF. <jats:italic>HSPA9<\/jats:italic> and <jats:italic>SOD2<\/jats:italic> may play a significant role in the occurrence and development of AF.<\/jats:p>","DOI":"10.1371\/journal.pone.0294282","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T18:30:02Z","timestamp":1699900202000},"page":"e0294282","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification and validation of aging-related genes in atrial fibrillation"],"prefix":"10.1371","volume":"18","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzhen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuodong","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5213-2668","authenticated-orcid":true,"given":"Qiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"issue":"5","key":"pone.0294282.ref001","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"G Hindricks","year":"2021","journal-title":"Eur Heart J"},{"issue":"1","key":"pone.0294282.ref002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/CIRCRESAHA.120.316340","article-title":"Epidemiology of Atrial Fibrillation in the 21st Century: Novel Methods and New Insights","volume":"127","author":"J Kornej","year":"2020","journal-title":"Circ Res"},{"issue":"9","key":"pone.0294282.ref003","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.117.309732","article-title":"Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes","volume":"120","author":"L Staerk","year":"2017","journal-title":"Circ Res"},{"issue":"5","key":"pone.0294282.ref004","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/hrt.2006.107573","article-title":"A national survey of the prevalence, incidence, primary care burden and treatment of atrial fibrillation in Scotland","volume":"93","author":"NF Murphy","year":"2007","journal-title":"Heart"},{"key":"pone.0294282.ref005","doi-asserted-by":"crossref","first-page":"101363","DOI":"10.1016\/j.arr.2021.101363","article-title":"The role of senescence in the pathogenesis of atrial fibrillation: A target process for health improvement and drug development","volume":"69","author":"G Guo","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"1","key":"pone.0294282.ref006","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.hrthm.2015.07.032","article-title":"Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study","volume":"13","author":"JF Carlquist","year":"2016","journal-title":"Heart Rhythm"},{"issue":"1","key":"pone.0294282.ref007","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9010036","article-title":"Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression","volume":"9","author":"L Jesel","year":"2019","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0294282.ref008","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-022-00347-9","article-title":"Atrial fibrillation","volume":"8","author":"B Brundel","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"pone.0294282.ref009","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jacep.2017.03.002","article-title":"Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation","volume":"3","author":"S Nattel","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"issue":"13","key":"pone.0294282.ref010","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1111\/febs.15282","article-title":"The ECM path of senescence in aging: components and modifiers","volume":"287","author":"N Levi","year":"2020","journal-title":"FEBS J"},{"issue":"1","key":"pone.0294282.ref011","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1038\/s41598-017-09675-3","article-title":"Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes","volume":"7","author":"N Kim","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0294282.ref012","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/eurheartj\/ehw119","article-title":"Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation","volume":"38","author":"HM Spronk","year":"2017","journal-title":"Eur Heart J"},{"key":"pone.0294282.ref013","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.yjmcc.2018.09.007","article-title":"The role of immune cells in atrial fibrillation","volume":"123","author":"Y Liu","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"pone.0294282.ref014","doi-asserted-by":"crossref","first-page":"927221","DOI":"10.3389\/fphys.2022.927221","article-title":"Immune remodeling and atrial fibrillation","volume":"13","author":"Y Yao","year":"2022","journal-title":"Front Physiol"},{"issue":"24","key":"pone.0294282.ref015","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1161\/01.CIR.0000103131.70301.4F","article-title":"Inflammation as a risk factor for atrial fibrillation","volume":"108","author":"RJ Aviles","year":"2003","journal-title":"Circulation"},{"issue":"9","key":"pone.0294282.ref016","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1540-8167.2010.01774.x","article-title":"Update on the association of inflammation and atrial fibrillation","volume":"21","author":"P Patel","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"pone.0294282.ref017","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines","volume":"9","author":"IM Rea","year":"2018","journal-title":"Front Immunol"},{"key":"pone.0294282.ref018","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijcard.2016.07.103","article-title":"Differential left-to-right atria gene expression ratio in human sinus rhythm and atrial fibrillation: Implications for arrhythmogenesis and thrombogenesis","volume":"222","author":"FC Tsai","year":"2016","journal-title":"Int J Cardiol"},{"issue":"3","key":"pone.0294282.ref019","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.hrthm.2012.11.013","article-title":"Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation","volume":"10","author":"YH Yeh","year":"2013","journal-title":"Heart Rhythm"},{"issue":"D1","key":"pone.0294282.ref020","doi-asserted-by":"crossref","first-page":"D1083","DOI":"10.1093\/nar\/gkx1042","article-title":"Human Ageing Genomic Resources: new and updated databases","volume":"46","author":"R Tacutu","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"pone.0294282.ref021","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"JT Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"pone.0294282.ref022","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an interactive Venn diagram viewer","volume":"15","author":"P Bardou","year":"2014","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"pone.0294282.ref023","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"G Yu","year":"2012","journal-title":"OMICS"},{"issue":"2","key":"pone.0294282.ref024","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"G Yu","year":"2016","journal-title":"Mol Biosyst"},{"issue":"4","key":"pone.0294282.ref025","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"CH Chin","year":"2014","journal-title":"BMC Syst Biol"},{"issue":"1","key":"pone.0294282.ref026","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13148-019-0730-1","article-title":"Statistical predictions with glmnet","volume":"11","author":"S Engebretsen","year":"2019","journal-title":"Clin Epigenetics"},{"issue":"1","key":"pone.0294282.ref027","first-page":"41","article-title":"Applications of Support Vector Machine (SVM) Learning in Cancer Genomics","volume":"15","author":"S Huang","year":"2018","journal-title":"Cancer Genomics Proteomics"},{"issue":"5","key":"pone.0294282.ref028","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"AM Newman","year":"2015","journal-title":"Nat Methods"},{"issue":"5","key":"pone.0294282.ref029","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1161\/01.CIR.91.5.1588","article-title":"Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation","volume":"91","author":"CA Morillo","year":"1995","journal-title":"Circulation"},{"issue":"4","key":"pone.0294282.ref030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"J. Campisi","year":"2005","journal-title":"Cell"},{"issue":"1","key":"pone.0294282.ref031","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12933-017-0604-9","article-title":"Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes","volume":"16","author":"BS Karam","year":"2017","journal-title":"Cardiovasc Diabetol"},{"issue":"23\u201324","key":"pone.0294282.ref032","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: many therapeutic avenues","volume":"34","author":"J Birch","year":"2020","journal-title":"Genes Dev"},{"issue":"8","key":"pone.0294282.ref033","first-page":"943","article-title":"Cardiac Fibrosis in Patients With Atrial Fibrillation: Mechanisms and Clinical Implications","volume":"66","author":"MS Dzeshka","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"pone.0294282.ref034","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.cell.2013.10.019","article-title":"Programmed cell senescence during mammalian embryonic development","volume":"155","author":"D Munoz-Espin","year":"2013","journal-title":"Cell"},{"issue":"2","key":"pone.0294282.ref035","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020320","article-title":"Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology","volume":"10","author":"S Kasai","year":"2020","journal-title":"Biomolecules"},{"key":"pone.0294282.ref036","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2020.01.009","article-title":"Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3","volume":"139","author":"CL Li","year":"2020","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"pone.0294282.ref037","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/biom2010143","article-title":"Mortalin, apoptosis, and neurodegeneration.","volume":"2","author":"C Londono","year":"2012","journal-title":"Biomolecules"},{"issue":"2","key":"pone.0294282.ref038","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ceca.2016.04.005","article-title":"Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy","volume":"60","author":"RM La Rovere","year":"2016","journal-title":"Cell Calcium"},{"issue":"5","key":"pone.0294282.ref039","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1002\/jcb.26653","article-title":"HMGB1-induced asthmatic airway inflammation through GRP75-mediated enhancement of ER-mitochondrial Ca(2+) transfer and ROS increased","volume":"119","author":"Y Lv","year":"2018","journal-title":"J Cell Biochem"},{"key":"pone.0294282.ref040","doi-asserted-by":"crossref","first-page":"102289","DOI":"10.1016\/j.redox.2022.102289","article-title":"IP3R1\/GRP75\/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling","volume":"52","author":"M Yuan","year":"2022","journal-title":"Redox Biol"},{"issue":"6","key":"pone.0294282.ref041","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00395-004-0477-4","article-title":"Expression of mortalin in patients with chronic atrial fibrillation","volume":"99","author":"K Kirmanoglou","year":"2004","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"pone.0294282.ref042","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/ng0298-99","article-title":"Loss of ROS\u2014a radical response","volume":"18","author":"S Przedborski","year":"1998","journal-title":"Nat Genet"},{"key":"pone.0294282.ref043","doi-asserted-by":"crossref","first-page":"116554","DOI":"10.1016\/j.lfs.2019.116554","article-title":"Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1\/2-SOD2 pathway","volume":"231","author":"Z Zhang","year":"2019","journal-title":"Life Sci"},{"issue":"5","key":"pone.0294282.ref044","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.117.310933","article-title":"Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension","volume":"121","author":"AE Dikalova","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"pone.0294282.ref045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1540-8167.2011.02186.x","article-title":"PPAR-gamma activator pioglitazone prevents age-related atrial fibrillation susceptibility by improving antioxidant capacity and reducing apoptosis in a rat model","volume":"23","author":"D Xu","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"pone.0294282.ref046","doi-asserted-by":"crossref","first-page":"113409","DOI":"10.1016\/j.psychres.2020.113409","article-title":"Galantamine-Memantine combination in the treatment of Alzheimer\u2019s disease and beyond","volume":"293","author":"MM Koola","year":"2020","journal-title":"Psychiatry Res"},{"issue":"9","key":"pone.0294282.ref047","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41422-021-00499-5","article-title":"Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes","volume":"31","author":"D Xie","year":"2021","journal-title":"Cell Res"},{"issue":"22","key":"pone.0294282.ref048","article-title":"The Effect of Oxidative Stress and Memantine-Incorporated Reactive Oxygen Species-Sensitive Nanoparticles on the Expression of N-Methyl-d-aspartate Receptor Subunit 1 in Brain Cancer Cells for Alzheimer\u2019s Disease Application","volume":"22","author":"JS Park","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"21","key":"pone.0294282.ref049","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111330","article-title":"Memantine Modulates Oxidative Stress in the Rat Brain following Experimental Autoimmune Encephalomyelitis","volume":"22","author":"B Dabrowska-Bouta","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pone.0294282.ref050","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10753-020-01365-z","article-title":"Memantine, NMDA Receptor Antagonist, Attenuates ox-LDL-Induced Inflammation and Oxidative Stress via Activation of BDNF\/TrkB Signaling Pathway in HUVECs","volume":"44","author":"Y Hao","year":"2021","journal-title":"Inflammation"},{"issue":"7","key":"pone.0294282.ref051","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1093\/cvr\/cvab177","article-title":"Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy","volume":"118","author":"F Wiedmann","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"1","key":"pone.0294282.ref052","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.120.316366","article-title":"Animal Models of Atrial Fibrillation","volume":"127","author":"D Schuttler","year":"2020","journal-title":"Circ Res"},{"issue":"9","key":"pone.0294282.ref053","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIRCULATIONAHA.108.776203","article-title":"Neural mechanisms of paroxysmal atrial fibrillation and paroxysmal atrial tachycardia in ambulatory canines","volume":"118","author":"AY Tan","year":"2008","journal-title":"Circulation"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0294282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T18:30:29Z","timestamp":1699900229000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0294282"}},"subtitle":[],"editor":[{"given":"Md. Zubbair","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0294282","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]}}}