{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:08:23Z","timestamp":1740146903473,"version":"3.37.3"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["30053"],"award-info":[{"award-number":["30053"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McLean Eric Dorris Translational Research Grant"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Treatment trials for borderline personality disorder (BPD) have consistently demonstrated that approaches that are diagnostically tailored are superior to those which are not. Currently, gold standard treatments for BPD are highly intensive, lengthy, and specialized, leading to a critical gap between the supply and demand of effective, evidence-based treatment for patients who receive a diagnosis of BPD. Psychoeducation, which is a common component of most treatments known to be effective, is a low-cost, low-burden intervention proven to relieve symptoms. The present study builds on psychoeducation research, assessing online video prescriptions as a means of disseminating information patients need to know about their diagnosis and care.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This article presents the study protocol for a safety, feasibility, and preliminary efficacy trial of psychoeducational video prescriptions and online assessment with feedback for newly diagnosed individuals with BPD. We aim to recruit 100 adults recently diagnosed with BPD to be randomly assigned to receive videos about BPD or videos about non-BPD mental health topics that are matched in length in the first step of the study. All participants will complete daily surveys about their emotions, interpersonal interactions, and behaviors, as well as self-report assessments and cognitive tests at 4 different time points. Half of the participants in the intervention group will receive feedback on their symptom ratings and cognitive test performance to assess whether there is incremental value in tailoring this online set of interventions with individualized feedback unique to each participant. This study aims to assess the effects of BPD-focused psychoeducational videos with and without personalized feedback, on BPD and depressive symptom severity as well as core mechanisms of the disorder such as loneliness, rejection sensitivity, cognitive control difficulties, and self-clarity. Results will inform efforts to progress to a larger, more definitive trial.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p><jats:bold>Clinical trials registration:<\/jats:bold> The protocol is registered with ClinicalTrials.gov  <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05358925\" xlink:type=\"simple\">NCT05358925<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0294331","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T18:35:46Z","timestamp":1701974146000},"page":"e0294331","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Online psychoeducation and digital assessments as a first step of treatment for borderline personality disorder: A protocol for a pilot randomized controlled trial"],"prefix":"10.1371","volume":"18","author":[{"given":"Lois W.","family":"Choi-Kain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace E.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Jurist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Germine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"4","key":"pone.0294331.ref001","first-page":"337","article-title":"Borderline personality disorder: Updates in a postpandemic world.","volume":"20","author":"LW Choi-Kain","year":"2022","journal-title":"Focus (Am Psychiatr Publ)."},{"issue":"4","key":"pone.0294331.ref002","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/jamapsychiatry.2016.4287","article-title":"Efficacy of psychotherapies for borderline personality disorder: A systematic review and meta-analysis","volume":"74","author":"IA Cristea","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"pone.0294331.ref003","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1176\/appi.ps.201900073","article-title":"Treatment of borderline personality disorder: Is supply adequate to meet public health needs?.","volume":"70","author":"EA Iliakis","year":"2019","journal-title":"Psychiatr Serv."},{"issue":"6","key":"pone.0294331.ref004","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000525102","article-title":"The Effectiveness of 6 versus 12 Months of Dialectical Behavior Therapy for Borderline Personality Disorder: A Noninferiority Randomized Clinical Trial.","volume":"91","author":"SF McMain","year":"2022","journal-title":"Psychother Psychosom."},{"issue":"1","key":"pone.0294331.ref005","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1186\/s13063-021-05450-y","article-title":"Detailed statistical analysis plan for the short-term versus long-term mentalisation-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder randomised clinical trial (MBT-RCT).","volume":"22","author":"S Juul","year":"2021","journal-title":"Trials."},{"issue":"10","key":"pone.0294331.ref006","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/0004867418791257","article-title":"Specialized psychotherapies for adults with borderline personality disorder: A systematic review and meta-analysis.","volume":"52","author":"M Oud","year":"2018","journal-title":"Aust N Z J Psychiatry"},{"issue":"3","key":"pone.0294331.ref007","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1192\/bjp.2021.204","article-title":"Psychotherapies for borderline personality disorder: A focused systematic review and meta-analysis.","volume":"221","author":"JM Stoffers-Winterling","year":"2022","journal-title":"B J Psychiatry"},{"key":"pone.0294331.ref008","first-page":"CD012955","article-title":"Psychological therapies for people with borderline personality disorder.","volume":"5","author":"OJ Storeb\u00f8","year":"2020","journal-title":"Cochrane Database Syst Rev."},{"issue":"3","key":"pone.0294331.ref009","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1521\/pedi.2008.22.3.284","article-title":"A preliminary, randomized trial of psychoeducation for women with borderline personality disorder.","volume":"22","author":"MC Zanarini","year":"2008","journal-title":"J Pers Disord."},{"issue":"3","key":"pone.0294331.ref010","first-page":"16m11153","article-title":"Randomized controlled trial of web-based psychoeducation for women with borderline personality disorder.","volume":"78","author":"MC Zanarini","year":"2017","journal-title":"J Clin Psychiatry."},{"issue":"1","key":"pone.0294331.ref011","first-page":"19m12723","article-title":"A clinical trial of a psychoeducation group intervention for patients with borderline personality disorder.","volume":"80","author":"ME Ridolfi","year":"2019","journal-title":"J Clin Psychiatry."},{"issue":"6","key":"pone.0294331.ref012","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1176\/appi.ps.201900448","article-title":"A randomized controlled trial of video psychoeducation for electroconvulsive therapy in the United States.","volume":"71","author":"J Tsai","year":"2020","journal-title":"Psychiatr Serv."},{"issue":"2","key":"pone.0294331.ref013","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s10865-012-9480-7","article-title":"Videos to influence: a systematic review of effectiveness of video-based education in modifying health behaviors.","volume":"37","author":"W Tuong","year":"2014","journal-title":"J Behav Med."},{"issue":"2","key":"pone.0294331.ref014","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archpsyc.1991.01810260051008","article-title":"Effectiveness of psychoeducational interventions in reducing emotional distress after human immunodeficiency virus antibody testing.","volume":"48","author":"S Perry","year":"1991","journal-title":"Arch Gen Psychiatry."},{"issue":"4","key":"pone.0294331.ref015","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1212\/WNL.0b013e3182604533","article-title":"A prescription for the Epley maneuver: www.youtube.com?.","volume":"79","author":"KA Kerber","year":"2012","journal-title":"Neurology"},{"key":"pone.0294331.ref016","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jpsychires.2021.10.009","article-title":"Impaired complex theory of mind and low emotional self-awareness in outpatients with borderline personality disorder compared to healthy controls: A cross-sectional study","volume":"143","author":"P Pourmohammad","year":"2021","journal-title":"J Psychiatr Res"},{"issue":"2","key":"pone.0294331.ref017","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1207\/S15327752JPA8002_01","article-title":"Therapeutic Assessment of a man with \"ADD\".","volume":"80","author":"SE Finn","year":"2003","journal-title":"J Pers Assess.1"},{"issue":"3","key":"pone.0294331.ref018","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1037\/1040-3590.4.3.272","article-title":"Neuropsychological test feedback to patients with brain dysfunction","volume":"4","author":"CS Gass","year":"1992","journal-title":"Psychol Assess"},{"issue":"3","key":"pone.0294331.ref019","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1177\/0022167807303735","article-title":"Therapeutic neuropsychological assessment: A humanistic model and case example.","volume":"48","author":"TT Gorske","year":"2008","journal-title":"J Humanist Psychol."},{"issue":"6","key":"pone.0294331.ref020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/erv.866","article-title":"Using neuropsychological feedback therapeutically in treatment for anorexia nervosa: Two illustrative case reports.","volume":"16","author":"C Lopez","year":"2008","journal-title":"Eur Eat Disord Rev."},{"issue":"2","key":"pone.0294331.ref021","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1037\/h0095322","article-title":"Neuropsychological assessment as an aid to psychosocial rehabilitation in severe mental disorders.","volume":"21","author":"AK Malla","year":"1997","journal-title":"Psychiatr Rehabil J"},{"issue":"1","key":"pone.0294331.ref022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17505\/jpor.2017.01","article-title":"Personalized Feedback on Symptom Dynamics of Psychopathology: A Proof-of-Principle Study.","volume":"3","author":"R Kroeze","year":"2017","journal-title":"J Pers Oriented Res.1"},{"issue":"1\u20133","key":"pone.0294331.ref023","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jad.2010.05.003","article-title":"Progress monitoring and feedback in psychiatric care reduces depressive symptoms","volume":"127","author":"EA Newnham","year":"2010","journal-title":"J Affect Disorder"},{"issue":"3","key":"pone.0294331.ref024","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/ptr\/kph027","article-title":"The therapeutic effects of providing patient progress information to therapists and patients","volume":"14","author":"EJ Hawkins","year":"2004","journal-title":"Psychother Res"},{"issue":"3","key":"pone.0294331.ref025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/13854046.2017.1400105","article-title":"Neuropsychological feedback services improve quality of life and social adjustment.","volume":"32","author":"DL Rosado","year":"2018","journal-title":"Clin Neuropsychol."},{"key":"pone.0294331.ref026","article-title":"Digital cognitive assessment: Results from the TestMyBrain NIMH Research Domain Criteria (RDoC) field test battery report.","author":"E Passell","year":"2019","journal-title":"PsyArXiv"},{"issue":"8","key":"pone.0294331.ref027","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1080\/13803395.2021.2002269","article-title":"The TestMyBrain Digital Neuropsychology Toolkit: Development and Psychometric Characteristics.","volume":"43","author":"S Singh","year":"2021","journal-title":"J Clin Exp Neuropsychol"},{"issue":"1","key":"pone.0294331.ref028","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000173701","article-title":"The short version of the Borderline Symptom List (BSL-23): development and initial data on psychometric properties.","volume":"42","author":"M Bohus","year":"2009","journal-title":"Psychopathology"},{"issue":"9","key":"pone.0294331.ref029","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ\u20109: validity of a brief depression severity measure","volume":"16","author":"K Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"issue":"6","key":"pone.0294331.ref030","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/0164027504268574","article-title":"A short scale for measuring loneliness in large surveys: Results from two population-based studies.","volume":"26","author":"ME Hughes","year":"2004","journal-title":"Res Aging."},{"key":"pone.0294331.ref031","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpsychires.2017.09.005","article-title":"A new scale for assessing wisdom based on common domains and a neurobiological model: The San Diego Wisdom Scale (SD-WISE).","volume":"108","author":"ML Thomas","year":"2019","journal-title":"J Psychiatr Res"},{"issue":"1","key":"pone.0294331.ref032","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pmh.1434","article-title":"The Level of Personality Functioning Scale\u2010Brief Form 2.0: Update of a brief instrument for assessing level of personality functioning.","volume":"13","author":"LC Weekers","year":"2019","journal-title":"Personal Ment Health."},{"key":"pone.0294331.ref033","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0149-7189(79)90094-6","article-title":"Assessment of client\/patient satisfaction: Development of a general scale","volume":"2","author":"DL Larsen","year":"1979","journal-title":"Eval Program Plann"},{"key":"pone.0294331.ref034","article-title":"Background Information Schedule.","author":"MC Zanarini","year":"1992","journal-title":"Belmont, Mass, McLean Hospital,"},{"key":"pone.0294331.ref035","volume-title":"WAIS-III WMS-III Technical Manual.","author":"D Tulsky","year":"2002","edition":"3"},{"issue":"539","key":"pone.0294331.ref036","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1080\/01621459.2020.1862669","article-title":"Semiparametric Inference for Nonmonotone Missing-Not-at-Random Data: The No Self-Censoring Model","volume":"117","author":"D Malinsky","year":"2022","journal-title":"J Am Stat Assoc"},{"issue":"1","key":"pone.0294331.ref037","first-page":"207","article-title":"Itemwise conditionally independent nonresponse modelling for incomplete multivariate data","volume":"104","author":"M Sadinle","year":"2017","journal-title":"Biometrika"},{"key":"pone.0294331.ref038","first-page":"9622802231188520","article-title":"Multiple imputation for non-monotone missing not at random data using the no self-censoring model.","volume":"30","author":"B Ren","year":"2023","journal-title":"Stat Methods Med Res."},{"key":"pone.0294331.ref039","first-page":"1","article-title":"mice: Multivariate imputation by chained equations in R.","volume":"45","author":"S Van Buuren","year":"2011","journal-title":"J Stat Softw"},{"key":"pone.0294331.ref040","doi-asserted-by":"crossref","DOI":"10.1002\/9780470316696","volume-title":"Multiple Imputation for Nonresponse in Surveys","author":"DB Rubin","year":"1987"},{"issue":"5","key":"pone.0294331.ref041","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1037\/0022-006X.73.5.914","article-title":"Estimating variability in outcomes attributable to therapists: a naturalistic study of outcomes in managed care.","volume":"73","author":"BE Wampold","year":"2005","journal-title":"J Consult Clin Psychol."},{"issue":"6","key":"pone.0294331.ref042","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1037\/0022-006X.75.6.842","article-title":"Untangling the alliance-outcome correlation: Exploring the relative importance of therapist and patient variability in the alliance.","volume":"75","author":"SA Baldwin","year":"2007","journal-title":"J Consult Clin Psychol."},{"issue":"1","key":"pone.0294331.ref043","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1521\/pedi.2008.22.1.22","article-title":"BPD\u2019s interpersonal hypersensitivity phenotype: A gene-environment-developmental model.","volume":"22","author":"JG Gunderson","year":"2008","journal-title":"J Pers Disord."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0294331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T18:36:14Z","timestamp":1701974174000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0294331"}},"subtitle":[],"editor":[{"given":"Stephan","family":"Doering","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":43,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0294331","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2023,12,7]]}}}