{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:34:38Z","timestamp":1793414078078,"version":"4.5.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcellular structures and its transcriptional control remain largely unknown. Here, we showed that <jats:italic>CCHCR1<\/jats:italic> shares a bidirectional promoter with its neighboring gene, <jats:italic>TCF19<\/jats:italic>. This bidirectional promoter is activated by the G1\/S-regulatory transcription factor E2F1, and both genes are co-induced during the G1\/S transition of the cell cycle. A luciferase reporter assay suggests that the short intergenic sequence, only 287 bp in length, is sufficient for the G1\/S induction of both genes, but the expression of <jats:italic>CCHCR1<\/jats:italic> is further enhanced by the presence of exon 1 from both <jats:italic>TCF19<\/jats:italic> and <jats:italic>CCHCR1<\/jats:italic>. This research uncovers the transcriptional regulation of the <jats:italic>CCHCR1<\/jats:italic> gene, offering new perspectives on its function. These findings contribute to the broader understanding of diseases associated with CCHCR1 and may serve as a foundational benchmark for future research in these vital medical fields.<\/jats:p>","DOI":"10.1371\/journal.pone.0294661","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:28:04Z","timestamp":1703183284000},"page":"e0294661","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-7759","authenticated-orcid":true,"given":"Yick Hin","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok Nam","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King Ming","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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