{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:38:22Z","timestamp":1755794302162,"version":"3.37.3"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305294"],"award-info":[{"award-number":["82305294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TCM Science and Technology Program of Zhejiang Province","award":["2023ZR038"],"award-info":[{"award-number":["2023ZR038"]}]},{"name":"Research Project of the Affiliated Hospital of Zhejiang Chinese Medical University","award":["2022FSYYZQ16"],"award-info":[{"award-number":["2022FSYYZQ16"]}]},{"name":"Hangzhou Health Science and Technology Project","award":["A20230675"],"award-info":[{"award-number":["A20230675"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305299"],"award-info":[{"award-number":["82305299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TCM Science and Technology Project of Zhejiang Province","award":["2022ZA120"],"award-info":[{"award-number":["2022ZA120"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M733193"],"award-info":[{"award-number":["2023M733193"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TCM Science and the Research Project of Zhejiang Chinese Medical University","award":["2022RCZXZK29"],"award-info":[{"award-number":["2022RCZXZK29"]}]},{"name":"Key project of Zhejiang Provincial Administration of Traditional Chinese Medicine","award":["2022ZZ025"],"award-info":[{"award-number":["2022ZZ025"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objectives<\/jats:title><jats:p>Unexplained recurrent spontaneous abortion (URSA) remains an intractable reproductive dilemma due to the lack of understanding of the pathogenesis. This study aimed to evaluate the preclinical evidence for the mesenchymal stromal cell (MSC) treatment for URSA.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>A meticulous literature search was independently performed by two authors across the Cochrane Library, EMBASE, and PubMed databases from inception to April 9, 2023. Each study incorporated was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool. The amalgamated standardized mean difference (SMD) accompanied by 95% confidence interval (CI) were deduced through a fixed-effects or random-effects model analysis.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>A total of ten studies incorporating 140 mice were subjected to data analysis. The MSC treatment yielded a significant reduction in the abortion rate within the URSA model (OR = 0.23, 95%CI [0.17, 0.3],<jats:italic>P<\/jats:italic>&lt;0.00001). Moreover, it elicited a positive modulatory impact on the expression profiles of several inflammatory cytokines in the decidual tissue of URSA murine models, inclusive of IL4 (SMD 1.63, 95% CI [0.39, 2.86],<jats:italic>P<\/jats:italic>= 0.01), IL10 (SMD 1.60, 95% CI [0.58, 2.61],<jats:italic>P<\/jats:italic>= 0.002), IFN-\u03b3 (SMD -1.66, 95%CI [-2.79, -0.52],<jats:italic>P<\/jats:italic>= 0.004), and TNF-\u03b1 (SMD -1.98, 95% CI [-2.93, -1.04],<jats:italic>P<\/jats:italic>&lt; 0.0001). Subgroup analyses underscored that the administration mode of intraperitoneal and uterine horn injections, and sources of bone MSCs and adipose-derived MSCs contributed positively to the expression of IL4, IL10, and decreased the expression of IFN-\u03b3 in decidual tissue of URSA (<jats:italic>P<\/jats:italic>&lt;0.05). Conversely, the tail vein injections subgroup was observed with no statistical significance (<jats:italic>P<\/jats:italic>&gt;0.05).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>The findings underscore the considerable potential of MSCs in URSA therapy. Nonetheless, the demand for enhanced transparency in research design and direct comparisons between various MSC sources and administration routes in URSA is paramount to engendering robust evidence that could pave the way for successful clinical translation.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0294855","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T19:14:28Z","timestamp":1701112468000},"page":"e0294855","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of mesenchymal stromal cells in the treatment of unexplained recurrent spontaneous abortion in mice: An analytical and systematic review of meta-analyses"],"prefix":"10.1371","volume":"18","author":[{"given":"Xiaoxuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuepeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-9844","authenticated-orcid":true,"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"issue":"6","key":"pone.0294855.ref001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/OGX.0000000000001033","article-title":"Recent Advances in Treatment of Recurrent Spontaneous Abortion [J].","volume":"77","author":"T Deng","year":"2022","journal-title":"Obstetrical & gynecological survey,"},{"issue":"1","key":"pone.0294855.ref002","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss [J]","volume":"6","author":"E Dimitriadis","year":"2020","journal-title":"Nature reviews Disease primers"},{"issue":"7","key":"pone.0294855.ref003","doi-asserted-by":"crossref","first-page":"432","DOI":"10.31128\/AJGP-01-18-4459","article-title":"Recurrent pregnancy loss: A summary of international evidence-based guidelines and practice [J]","volume":"47","author":"Y Hong Li","year":"2018","journal-title":"Australian journal of general practice"},{"issue":"10285","key":"pone.0294855.ref004","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss [J]","volume":"397","author":"S Quenby","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"pone.0294855.ref005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/1547691X.2014.978056","article-title":"Association between lower frequency of R381Q variant (rs11209026) in IL-23 receptor gene and increased risk of recurrent spontaneous abortion (RSA) [J].","volume":"12","author":"E Abdollahi","year":"2015","journal-title":"Journal of immunotoxicology"},{"key":"pone.0294855.ref006","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bpobgyn.2019.07.005","article-title":"Immunotherapy for recurrent pregnancy loss [J].","volume":"60","author":"H. CARP","year":"2019","journal-title":"Best practice & research Clinical obstetrics & gynaecology"},{"issue":"1","key":"pone.0294855.ref007","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3727\/096368910X","article-title":"Mesenchymal stem cells [J].","volume":"20","author":"C Ding D","year":"2011","journal-title":"Cell transplantation"},{"issue":"30","key":"pone.0294855.ref008","doi-asserted-by":"crossref","first-page":"eaba6884","DOI":"10.1126\/sciadv.aba6884","article-title":"Shattering barriers toward clinically meaningful MSC therapies [J]","volume":"6","author":"O Levy","year":"2020","journal-title":"Science advances"},{"issue":"3","key":"pone.0294855.ref009","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged [J]","volume":"32","author":"A Ankrum J","year":"2014","journal-title":"Nature biotechnology"},{"issue":"1","key":"pone.0294855.ref010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1574888X10666150904114035","article-title":"Cross-Talk Between Mesenchymal Stem\/Stromal Cells and Dendritic Cells [J]","volume":"11","author":"M \u00d0oki\u0107 J","year":"2016","journal-title":"Current stem cell research & therapy"},{"issue":"4","key":"pone.0294855.ref011","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1530\/REP-20-0320","article-title":"Mesenchymal stem cells induce expansion of regulatory T cells in abortion-prone mice [J]","volume":"161","author":"A Salek Farrokhi","year":"2021","journal-title":"Reproduction (Cambridge, England),"},{"issue":"3","key":"pone.0294855.ref012","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-2567.2012.03621.x","article-title":"Mesenchymal stromal cells: a key player in \u2019innate tolerance\u2019? [J].","volume":"137","author":"F Dazzi","year":"2012","journal-title":"Immunology"},{"key":"pone.0294855.ref013","doi-asserted-by":"crossref","first-page":"84","DOI":"10.21037\/sci.2017.09.06","article-title":"Clinical potential of mesenchymal stem\/stromal cell-derived extracellular vesicles [J]","volume":"4","author":"B Giebel","year":"2017","journal-title":"Stem cell investigation"},{"issue":"10","key":"pone.0294855.ref014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103240","article-title":"Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions [J]","volume":"19","author":"N Tempest","year":"2018","journal-title":"International journal of molecular sciences"},{"key":"pone.0294855.ref015","first-page":"n160","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews [J].","volume":"372","author":"J Page M","year":"2021","journal-title":"BMJ (Clinical research ed),"},{"key":"pone.0294855.ref016","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1745-6215-8-16","article-title":"Practical methods for incorporating summary time-to-event data into meta-analysis [J].","volume":"8","author":"F Tierney J","year":"2007","journal-title":"Trials"},{"key":"pone.0294855.ref017","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE\u2019s risk of bias tool for animal studies [J].","volume":"14","author":"R Hooijmans C","year":"2014","journal-title":"BMC medical research methodology,"},{"key":"pone.0294855.ref018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample [J].","volume":"5","author":"P Hozo S","year":"2005","journal-title":"BMC medical research methodology,"},{"key":"pone.0294855.ref019","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials [J]","volume":"343","author":"P Higgins J","year":"2011","journal-title":"BMJ (Clinical research ed),"},{"key":"pone.0294855.ref020","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.placenta.2016.08.089","article-title":"Bone mesenchymal stem cells improve pregnancy outcome by inducing maternal tolerance to the allogeneic fetus in abortion-prone matings in mouse [J]","volume":"47","author":"H Meng Y","year":"2016","journal-title":"Placenta"},{"issue":"3","key":"pone.0294855.ref021","first-page":"274","article-title":"Uterine Dendritic Cells Modulation by Mesenchymal Stem Cells Provides A Protective Microenvironment at The Feto-Maternal Interface: Improved Pregnancy Outcome in Abortion-Prone Mice [J].","volume":"21","author":"M Eskandarian","year":"2019","journal-title":"Cell journal"},{"issue":"8","key":"pone.0294855.ref022","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1177\/1933719117737848","article-title":"Mesenchymal Stem Cell Therapy Prevents Abortion in CBA\/J \u00d7 DBA\/2 Mating [J].","volume":"25","author":"B Sadighi-Moghaddam","year":"2018","journal-title":"Reproductive sciences (Thousand Oaks, Calif)"},{"issue":"10","key":"pone.0294855.ref023","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1002\/jcp.29620","article-title":"Mesenchymal stem cells alter the frequency and cytokine profile of natural killer cells in abortion-prone mice [J]","volume":"235","author":"F Rezaei Kahmini","year":"2020","journal-title":"Journal of cellular physiology"},{"issue":"5","key":"pone.0294855.ref024","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/kjm2.12178","article-title":"Mesenchymal stem cells-derived exosomes improve pregnancy outcome through inducing maternal tolerance to the allogeneic fetus in abortion-prone mating mouse [J]","volume":"36","author":"J Xiang Y","year":"2020","journal-title":"The Kaohsiung journal of medical sciences"},{"issue":"1","key":"pone.0294855.ref025","first-page":"92","article-title":"Comparison of The Therapeutic Effect of Syngeneic, Allogeneic, and Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Abortion Rates in A Mouse Model [J].","volume":"21","author":"F Rezaei","year":"2019","journal-title":"Cell journal"},{"key":"pone.0294855.ref026","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.trim.2018.01.002","article-title":"Mesenchymal stem cells therapy protects fetuses from resorption and induces Th2 type cytokines profile in abortion prone mouse model [J]","volume":"47","author":"A Salek Farrokhi","year":"2018","journal-title":"Transplant immunology"},{"key":"pone.0294855.ref027","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.molimm.2021.11.010","article-title":"Mesenchymal stem cell therapy attenuates complement C3 deposition and improves the delicate equilibrium between angiogenic and anti-angiogenic factors in abortion-prone mice [J]","volume":"141","author":"S Shahgaldi","year":"2022","journal-title":"Molecular immunology"},{"key":"pone.0294855.ref028","doi-asserted-by":"crossref","first-page":"103366","DOI":"10.1016\/j.jri.2021.103366","article-title":"Mesenchymal stem cells enhance Treg immunosuppressive function at the fetal-maternal interface [J]","volume":"148","author":"D Zhang","year":"2021","journal-title":"Journal of reproductive immunology"},{"issue":"4","key":"pone.0294855.ref029","doi-asserted-by":"crossref","first-page":"e13095","DOI":"10.1111\/sji.13095","article-title":"Association of reduced maternal sHLA-G5 isoform levels and elevated TNF-\u03b1\/IL-4 cytokine ratio with Recurrent Pregnancy Loss: A study on South Indian women [J]","volume":"94","author":"D Madduru","year":"2021","journal-title":"Scand J Immunol"},{"issue":"3","key":"pone.0294855.ref030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000480734","article-title":"Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-\u03b3 Decrease from the Third Trimester of Pregnancy to Active Labor [J]","volume":"24","author":"JJ Reyes-Lagos","year":"2017","journal-title":"Neuroimmunomodulation"},{"issue":"1","key":"pone.0294855.ref031","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/vim.2019.0076","article-title":"Protective and Pathogenic Effects of Interferon Signaling During Pregnancy [J]","volume":"33","author":"RL Casazza","year":"2020","journal-title":"Viral Immunol"},{"issue":"6","key":"pone.0294855.ref032","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.3390\/ijms22062922","article-title":"The Role of TNF-\u03b1 and Anti-TNF-\u03b1 Agents during Preconception, Pregnancy, and Breastfeeding [J]","volume":"22","author":"K Romanowska-Pr\u00f3chnicka","year":"2021","journal-title":"International journal of molecular sciences"},{"issue":"12","key":"pone.0294855.ref033","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1007\/s43032-021-00599-y","article-title":"The Role of Immune Cells in Recurrent Spontaneous Abortion [J].","volume":"28","author":"D Li","year":"2021","journal-title":"Reproductive sciences (Thousand Oaks, Calif)"},{"key":"pone.0294855.ref034","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fimmu.2014.00253","article-title":"Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy [J]","volume":"5","author":"P Chatterjee","year":"2014","journal-title":"Frontiers in immunology"},{"issue":"8","key":"pone.0294855.ref035","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nri.2017.38","article-title":"Immunological implications of pregnancy-induced microchimerism [J]","volume":"17","author":"M Kinder J","year":"2017","journal-title":"Nature reviews Immunology"},{"issue":"1","key":"pone.0294855.ref036","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejogrb.2010.11.007","article-title":"Decidual CD4+CD25+CD127dim\/- regulatory T cells in patients with unexplained recurrent spontaneous miscarriage [J]","volume":"155","author":"H Bao S","year":"2011","journal-title":"European journal of obstetrics, gynecology, and reproductive biology,"},{"key":"pone.0294855.ref037","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1477-7827-12-74","article-title":"Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy [J]","volume":"12","author":"L Wu","year":"2014","journal-title":"Reproductive biology and endocrinology: RB&E"},{"issue":"6","key":"pone.0294855.ref038","doi-asserted-by":"crossref","first-page":"e0128219","DOI":"10.1371\/journal.pone.0128219","article-title":"Elevated Serum Level of IL-35 Associated with the Maintenance of Maternal-Fetal Immune Tolerance in Normal Pregnancy [J].","volume":"10","author":"Y Yue C","year":"2015","journal-title":"PloS one"},{"key":"pone.0294855.ref039","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.3389\/fimmu.2018.02126","article-title":"Cytokine-Based Generation of CD49a(+)Eomes(-\/+) Natural Killer Cell Subsets [J].","volume":"9","author":"X Ni","year":"2018","journal-title":"Frontiers in immunology"},{"issue":"1","key":"pone.0294855.ref040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010132","article-title":"The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses [J]","volume":"24","author":"X Yang","year":"2022","journal-title":"International journal of molecular sciences"},{"key":"pone.0294855.ref041","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jri.2016.04.288","article-title":"The importance of being a regulatory T cell in pregnancy [J]","volume":"116","author":"A. Clark D","year":"2016","journal-title":"Journal of reproductive immunology"},{"issue":"5","key":"pone.0294855.ref042","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1530\/REP-13-0583","article-title":"To drive or be driven: the path of a mouse model of recurrent pregnancy loss [J]","volume":"147","author":"A Bonney E","year":"2014","journal-title":"Reproduction (Cambridge, England),"},{"issue":"2","key":"pone.0294855.ref043","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/cdd.2013.158","article-title":"Immunobiology of mesenchymal stem cells [J]","volume":"21","author":"S Ma","year":"2014","journal-title":"Cell death and differentiation"},{"issue":"11","key":"pone.0294855.ref044","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.stem.2022.10.001","article-title":"Reciprocal regulation of mesenchymal stem cells and immune responses [J].","volume":"29","author":"Y Wang","year":"2022","journal-title":"Cell stem cell"},{"key":"pone.0294855.ref045","doi-asserted-by":"crossref","first-page":"728190","DOI":"10.3389\/fimmu.2021.728190","article-title":"Mesenchymal Stem Cell Therapy: Hope for Patients With Systemic Lupus Erythematosus [J","volume":"12","author":"A Li","year":"2021","journal-title":"]. Frontiers in immunology"},{"issue":"2","key":"pone.0294855.ref046","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s12015-013-9430-y","article-title":"NK and MSCs crosstalk: the sense of immunomodulation and their sensitivity [J]","volume":"9","author":"G Casado J","year":"2013","journal-title":"Stem cell reviews and reports"},{"issue":"4","key":"pone.0294855.ref047","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.it.2018.01.007","article-title":"Immunology of the Uterine and Vaginal Mucosae [J]","volume":"39","author":"Z Zhou J","year":"2018","journal-title":"Trends in immunology"},{"issue":"2\u20134","key":"pone.0294855.ref048","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1387\/ijdb.140096sr","article-title":"Immunological determinants of implantation success [J]","volume":"58","author":"A Robertson S","year":"2014","journal-title":"The International journal of developmental biology"},{"issue":"7","key":"pone.0294855.ref049","doi-asserted-by":"crossref","first-page":"520","DOI":"10.17772\/gp\/57823","article-title":"Effects of sildenafil citrate and etanercept treatment on TNF-\u03b1 levels in peripheral blood of women with recurrent miscarriage [J].","volume":"86","author":"M Ohams","year":"2015","journal-title":"Ginekologia polska"},{"issue":"7","key":"pone.0294855.ref050","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1055\/a-0634-1813","article-title":"Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion [J].","volume":"78","author":"X Zhao","year":"2018","journal-title":"Geburtshilfe und Frauenheilkunde"},{"issue":"2","key":"pone.0294855.ref051","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5114\/ceji.2017.69357","article-title":"Expression level of TNF-\u03b1 in decidual tissue and peripheral blood of patients with recurrent spontaneous abortion [J]","volume":"42","author":"S Li","year":"2017","journal-title":"Central-European journal of immunology"},{"issue":"4","key":"pone.0294855.ref052","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1095\/biolreprod.103.022640","article-title":"Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy [J]","volume":"70","author":"M Blois S","year":"2004","journal-title":"Biology of reproduction"},{"issue":"4","key":"pone.0294855.ref053","doi-asserted-by":"crossref","first-page":"e0123439","DOI":"10.1371\/journal.pone.0123439","article-title":"Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells [J].","volume":"10","author":"S Tripathi","year":"2015","journal-title":"PloS one"},{"issue":"1","key":"pone.0294855.ref054","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/mmr.2015.3409","article-title":"Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis [J].","volume":"12","author":"C Shen","year":"2015","journal-title":"Molecular medicine reports"},{"key":"pone.0294855.ref055","first-page":"2541275","article-title":"Human Adipose-Derived Stem Cells Exhibit Enhanced Proliferative Capacity and Retain Multipotency Longer than Donor-Matched Bone Marrow Mesenchymal Stem Cells during Expansion In Vitro [J].","volume":"2017","author":"L Burrow K","year":"2017","journal-title":"tem cells international,"},{"issue":"8","key":"pone.0294855.ref056","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/stem.3367","article-title":"Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium [J]","volume":"39","author":"M Diniz-Da-Costa","year":"2021","journal-title":"Stem cells (Dayton, Ohio),"},{"issue":"9","key":"pone.0294855.ref057","doi-asserted-by":"crossref","first-page":"e3000421","DOI":"10.1371\/journal.pbio.3000421","article-title":"Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy [J]","volume":"17","author":"R Tal","year":"2019","journal-title":"PLoS biology"},{"key":"pone.0294855.ref058","first-page":"6279721","article-title":"Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization [J].","volume":"2019","author":"V Wu","year":"2019","journal-title":"Stem cells international"},{"issue":"(5","key":"pone.0294855.ref059","doi-asserted-by":"crossref","first-page":"e014397","DOI":"10.1161\/JAHA.119.014397","article-title":"Mesenchymal Stem Cells Promote the Resolution of Cardiac Inflammation After Ischemia Reperfusion Via Enhancing Efferocytosis of Neutrophils [J].","volume":"9","author":"Z Zhang","year":"2020","journal-title":"Journal of the American Heart Association"},{"issue":"5","key":"pone.0294855.ref060","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/humrep\/deu014","article-title":"Adoptive transfer of pregnancy-induced CD4+CD25+ regulatory T cells reverses the increase in abortion rate caused by interleukin 17 in the CBA\/JxBALB\/c mouse model [J]","volume":"29","author":"J Wang W","year":"2014","journal-title":"Human reproduction (Oxford, England),"},{"issue":"26","key":"pone.0294855.ref061","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.7150\/thno.47683","article-title":"Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice [J].","volume":"10","author":"J Xu","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"pone.0294855.ref062","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13287-015-0003-7","article-title":"Influence of mesenchymal stem cells on metastasis development in mice in vivo [J].","volume":"6","author":"V Meleshina A","year":"2015","journal-title":"Stem cell research & therapy,"},{"key":"pone.0294855.ref063","doi-asserted-by":"crossref","first-page":"3970942","DOI":"10.1155\/2016\/3970942","article-title":"In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging [J","volume":"2016","author":"J Cao","year":"2016","journal-title":"]. Stem cells international"},{"issue":"1","key":"pone.0294855.ref064","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6 [J].","volume":"5","author":"H Lee R","year":"2009","journal-title":"Cell stem cell"},{"issue":"3","key":"pone.0294855.ref065","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.yexmp.2013.03.002","article-title":"Transplantation of bone marrow-derived MSCs improves cisplatinum-induced renal injury through paracrine mechanisms [J]","volume":"94","author":"K Cheng","year":"2013","journal-title":"Experimental and molecular pathology"},{"key":"pone.0294855.ref066","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fimmu.2012.00297","article-title":"Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion [J].","volume":"3","author":"E Eggenhofer","year":"2012","journal-title":"Frontiers in immunology"},{"key":"pone.0294855.ref067","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jare.2021.09.001","article-title":"A comparative study of Mesenchymal Stem Cells transplantation approach to antagonize age-associated ovarian hypofunction with consideration of safety and efficiency [J].","volume":"38","author":"L Wang","year":"2022","journal-title":"Journal of advanced research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0294855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T23:31:50Z","timestamp":1730676710000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0294855"}},"subtitle":[],"editor":[{"given":"Syed M.","family":"Faisal","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0294855","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2023,11,27]]}}}