{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:55:21Z","timestamp":1790906121114,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ryggforeningen i Norge via Stiftelsen Dam, Norway","award":["2020\/FO296562"],"award-info":[{"award-number":["2020\/FO296562"]}]},{"name":"Campus Akershus University Hospital, Institute of Clinical Medicine, University of Oslo"},{"name":"Department for Interdisciplinary Health Sciences, Institute of Health and Society, Faculty of Medicine, University of Oslo"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Neck pain poses enormous individual and societal costs worldwide. Spinal manipulative therapy and <jats:bold>N<\/jats:bold>on-<jats:bold>S<\/jats:bold>teroidal <jats:bold>A<\/jats:bold>nti-<jats:bold>I<\/jats:bold>nflammatory <jats:bold>D<\/jats:bold>rug treatment are frequently used despite a lack of compelling efficacy data. This protocol describes a multicentre 4-arm, clinical placebo randomized controlled trial (RCT), investigating the efficacy of chiropractic spinal manipulative therapy (CSMT) versus sham CSMT, ibuprofen, and placebo medicine for acute neck pain. This superiority study will employ parallel groups, featuring a 1:1:1:1 allocation ratio.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Material and methods<\/jats:title>\n<jats:p>We will randomize 320 participants equally into four groups: CSMT, sham CSMT, ibuprofen, or placebo medicine. CSMT groups are single-blinded, while the medicine groups are double-blinded. Data will be collected at baseline (Day 0), during treatment and post-treatment. The primary endpoint will assess the difference in mean pain intensity from Day 0 to Day 14 on a numeric rating scale 0\u201310; the CSMT group is compared to sham CSMT, ibuprofen, and placebo medicine groups, respectively. Secondary endpoints will assess mean pain intensity and mean duration at different time points, and adverse events, blinding success, and treatment satisfaction, including comparison between ibuprofen and placebo medicine. Power calculation is based on a mean neck pain rating of 5 at Day 0, with standard deviation of 1 in all groups. Mean pain reduction at Day 14 is expected to be 60% in the CSMT group, 40% in sham CSMT and ibuprofen groups, and 20% in the placebo medicine group. A linear mixed model will compare the mean values for groups with corresponding 95% confidence intervals. P values below 0.017 will be considered statistically significant. All analyses will be conducted blinded from group allocation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>This RCT aims towards the highest research standards possible for manual-therapy RCTs owing to its two placebo arms. If CSMT and\/or ibuprofen proves to be effective, it will provide evidence-based support for CSMT and\/or ibuprofen for acute neck pain.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>ClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05374057\" xlink:type=\"simple\">NCT05374057<\/jats:ext-link>. EU Clinical Trials Register: EudraCT number: 2021-005483-21.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0295115","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T18:37:35Z","timestamp":1701974255000},"page":"e0295115","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chiropractic spinal manipulative therapy for acute neck pain: A 4-arm clinical placebo randomized controlled trial. 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