{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:14:15Z","timestamp":1789978455583,"version":"4.0.1"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Mexico","award":["181508, 1782, FC218-2023"],"award-info":[{"award-number":["181508, 1782, FC218-2023"]}]},{"name":"UNAM DGAPA PAPIIT","award":["IB201712, IG200117, IN204720, IN213423"],"award-info":[{"award-number":["IB201712, IG200117, IN204720, IN213423"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Mexico","award":["329866"],"award-info":[{"award-number":["329866"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Mexico","award":["478686"],"award-info":[{"award-number":["478686"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Temporal lobe epilepsy (TLE) is a common form of medically intractable epilepsy. Although seizures originate in mesial temporal structures, there are widespread abnormalities of gray and white matter beyond the temporal lobes that negatively impact functional networks and cognition. Previous studies have focused either on the global impact on functional networks, or on the functional correlates of specific cognitive abilities. Here, we use a two-pronged approach to evaluate the link between whole-brain functional connectivity (FC) anomalies to overall cognitive performance, and how such abnormal connectivity alters the fronto-parietal brain regions involved in working memory (WMem), a cognitive disability often reported by TLE patients. We evaluated 31 TLE patients and 35 healthy subjects through extensive cognitive testing, resting-state functional magnetic resonance imaging (RS-fMRI), and task-based fMRI using Sternberg\u2019s task to evaluate WMem. As a group, TLE patients displayed cognitive abnormalities across different domains, although considerable within-group variability was identified. TLE patients showed disruptions of functional networks between and within the default mode network (DMN) and task-positive networks (TPN) resulting in associations with cognitive performance. Furthermore, during the WMem task, TLE patients showed abnormal activity of fronto-parietal regions that were associated with other forms of memory, and alterations of seed-based connectivity analyses. Our results show that different degrees of abnormal functional brain activity and connectivity are related to the severity of disabilities across cognitive spheres. Differential co-activation patterns between patients and healthy subjects suggest potential compensatory mechanisms to preserve adequate cognitive performance.<\/jats:p>","DOI":"10.1371\/journal.pone.0295142","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:31:29Z","timestamp":1710336689000},"page":"e0295142","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: Insights from task-based and resting-state fMRI"],"prefix":"10.1371","volume":"19","author":[{"given":"Alfonso","family":"Fajardo-Valdez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Camacho-T\u00e9llez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2917-1212","authenticated-orcid":true,"given":"Ra\u00fal","family":"Rodr\u00edguez-Cruces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-7089","authenticated-orcid":true,"given":"Mar\u00eda Luisa","family":"Garc\u00eda-Gomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-0833","authenticated-orcid":true,"given":"Erick Humberto","family":"Pasaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-3869","authenticated-orcid":true,"given":"Luis","family":"Concha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"pone.0295142.ref001","first-page":"630853","article-title":"A review of the epidemiology of temporal lobe epilepsy","volume":"2012","author":"JF T\u00e9llez-Zenteno","year":"2012","journal-title":"Epilepsy Res Treat"},{"issue":"5","key":"pone.0295142.ref002","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1034\/j.1600-0404.2000.90257a.x","article-title":"Quality of life and memory performance in patients with temporal lobe epilepsy","volume":"101","author":"AR Giovagnoli","year":"2000","journal-title":"Acta Neurol Scand"},{"key":"pone.0295142.ref003","article-title":"Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures","author":"MR Khalife","year":"2022","journal-title":"Front Neurol"},{"issue":"1","key":"pone.0295142.ref004","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0920-1211(00)00126-1","article-title":"The impact of epilepsy from the patient\u2019s perspective I. 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