{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:21:53Z","timestamp":1747196513638,"version":"3.40.5"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Stress is a risk factor for central serous chorioretinopathy (CSC), but a suitable biomarker of this stress has not been identified. We aimed to evaluate alpha-klotho (\u03b1Kl) as a potential biomarker of CSC. The circulating concentrations of \u03b1Kl in patients diagnosed with acute or chronic CSC and treated at Hyogo College of Medicine between December 2019 and July 2021 were retrospectively compared with those of healthy individuals. We also compared the \u03b1Kl concentrations of patients with acute or chronic CSC. Furthermore, we evaluated the relationships of age, sex, smoking status, and subfoveal choroidal thickness (SFCT) with \u03b1Kl concentration. Patients in whom subretinal fluid reaccumulated in the same eye after its resolution were defined as having recurrent CSC. We studied 56 patients (46 men and 10 women) and 27 healthy controls (19 men and 8 women); and 38 and 18 eyes with acute and chronic CSC, respectively. The mean circulating concentration of \u03b1Kl was higher in patients with CSC than in controls (827\u00b1232 and 724\u00b1183 pg\/mL, respectively; <jats:italic>p<\/jats:italic> = 0.035). The mean SFCT was greater in patients with CSC than in controls (416\u00b191.0 and 278\u00b196.3 \u03bcm, respectively; <jats:italic>p<\/jats:italic>&lt;0.0001). The mean \u03b1Kl concentration was significantly higher in the patients with acute CSC than in those with chronic CSC (898\u00b1221 and 740\u00b1224 pg\/mL, respectively; <jats:italic>p<\/jats:italic> = 0.038). Recurrence of CSC occurred in 10 of 56 (17.9%) eyes, of which five eyes were in the acute CSC group and five were in the chronic CSC group. Patients who experienced recurrence had significantly higher \u03b1KI concentrations than those who did not (<jats:italic>p<\/jats:italic> = 0.0219). There were no significant relationships of \u03b1Kl concentration with age, sex, smoking history, or SFCT. In summary, the circulating \u03b1KI concentrations of patients with CSC are high, which suggests that \u03b1KI may be an indicator of stress in such patients.<\/jats:p>","DOI":"10.1371\/journal.pone.0295795","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:55:22Z","timestamp":1703184922000},"page":"e0295795","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patients with central serous chorioretinopathy have high circulating alpha-klotho concentrations"],"prefix":"10.1371","volume":"18","author":[{"given":"Eri","family":"Tahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-6366","authenticated-orcid":true,"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Sugisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-8817","authenticated-orcid":true,"given":"Fumi","family":"Gomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"pone.0295795.ref001","doi-asserted-by":"crossref","first-page":"100865","DOI":"10.1016\/j.preteyeres.2020.100865","article-title":"Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities.","author":"R Kaye","year":"2020","journal-title":"Prog Retin Eye Res."},{"key":"pone.0295795.ref002","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.05.003","article-title":"Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.","volume":"48","author":"A Daruich","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"pone.0295795.ref003","doi-asserted-by":"crossref","first-page":"100955","DOI":"10.1016\/j.preteyeres.2021.100955","article-title":"The differential diagnosis of central serous chorioretinopathy and other diseases associated with subretinal fluid in the macula.","author":"EHC van Dijk","year":"2021","journal-title":"Prog Retin Eye Res."},{"key":"pone.0295795.ref004","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.oret.2017.02.009","article-title":"Physiologic and Psychologic Risk Factors in Central Serous Chorioretinopathy.","volume":"1","author":"AM Mansour","year":"2017","journal-title":"Ophthalmol Retin."},{"key":"pone.0295795.ref005","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00417-018-3985-x","article-title":"The relationship between the central serous chorioretinopathy, choroidal thickness, and serum hormone levels","volume":"256","author":"E \u00c7ilo\u011flu","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"pone.0295795.ref006","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/jim-2018-000977","article-title":"Implication of alpha-Klotho as the predictive factor of stress.","volume":"67","author":"K Nakanishi","year":"2019","journal-title":"J Investig Med"},{"key":"pone.0295795.ref007","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1165\/ajrcmb.22.1.3554","article-title":"Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life","volume":"22","author":"T Suga","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"pone.0295795.ref008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"M Kuro-o","year":"1997","journal-title":"Nature"},{"issue":"11","key":"pone.0295795.ref009","first-page":"2058","article-title":"Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure","volume":"123AD","author":"M Taneike","journal-title":"Sci Reports |"},{"key":"pone.0295795.ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2019.07.003","article-title":"Central serous chorioretinopathy: Towards an evidence-based treatment guideline.","volume":"73","author":"TJ van Rijssen","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"pone.0295795.ref011","first-page":"5","article-title":"Klotho-related Molecules Upregulated by Smoking Habit in Apparently Healthy Men: A Cross-sectional Study.","author":"K Nakanishi","year":"2015","journal-title":"Sci Rep."},{"key":"pone.0295795.ref012","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1176\/ajp.2006.163.9.1630","article-title":"Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress.","volume":"163","author":"TWW Pace","year":"2006","journal-title":"Am J Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0295795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:55:43Z","timestamp":1703184943000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0295795"}},"subtitle":[],"editor":[{"given":"Tatsuya","family":"Inoue","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":12,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0295795","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2023,12,21]]}}}