{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:45:29Z","timestamp":1768290329195,"version":"3.49.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center","award":["2018\/29\/B\/NZ1\/00549"],"award-info":[{"award-number":["2018\/29\/B\/NZ1\/00549"]}]},{"name":"National Science Center","award":["2018\/02\/X\/NZ1\/02680"],"award-info":[{"award-number":["2018\/02\/X\/NZ1\/02680"]}]},{"name":"National Science Center","award":["2018\/31\/B\/NZ1\/02612"],"award-info":[{"award-number":["2018\/31\/B\/NZ1\/02612"]}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["2018-05838"],"award-info":[{"award-number":["2018-05838"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The 24B_1 small non-coding RNA molecule has been identified in<jats:italic>Escherichia coli<\/jats:italic>after induction of Shiga toxin-converting bacteriophage \u03a624<jats:sub>B<\/jats:sub>. In this work, we focused on its direct role during phage and bacterial host development. We observed that in many aspects, this phage sRNA resembles herpesviral microRNAs. Similar to microRNAs, the mature 24B_1 is a short molecule, consisting of just 20 nucleotides. It is generated by cleaving the 80-nt long precursor transcript, and likely it undergoes a multi-step maturation process in which the Hfq protein plays an important role, as confirmed by demonstration of its binding to the 24B_1 precursor, but not to the 24B_1 mature form. Moreover, 24B_1 plays a significant role in maintaining the prophage state and reprogramming the host\u2019s energy metabolism. We proved that overproduction of this molecule causes the opposite physiological effects to the mutant devoid of the<jats:italic>24B_1<\/jats:italic>gene, and thus, favors the lysogenic pathway. Furthermore, the 24B_1 overrepresentation significantly increases the efficiency of expression of phage genes coding for proteins CI, CII, and CIII which are engaged in the maintenance of the prophage. It seems that through binding to mRNA of the<jats:italic>sdhB<\/jats:italic>gene, coding for the succinate dehydrogenase subunit, the 24B_1 alters the central carbon metabolism and causes a drop in the ATP intracellular level. Interestingly, a similar effect, called the Warburg switch, is caused by herpesviral microRNAs and it is observed in cancer cells. The advantage of the Warburg effect is still unclear, however, it was proposed that the metabolism of cancer cells, and all rapidly dividing cells, is adopted to convert nutrients such as glucose and glutamine faster and more efficiently into biomass. The availability of essential building blocks, such as nucleotides, amino acids, and lipids, is crucial for effective cell proliferation which in turn is essential for the prophage and its host to stay in the lysogenic state.<\/jats:p>","DOI":"10.1371\/journal.pone.0296038","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T18:37:32Z","timestamp":1703097452000},"page":"e0296038","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bacteriophage-encoded 24B_1 molecule resembles herpesviral microRNAs and plays a crucial role in the development of both the virus and its host"],"prefix":"10.1371","volume":"18","author":[{"given":"Sylwia","family":"Bloch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Lewandowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-0702","authenticated-orcid":true,"given":"Joanna","family":"Zwolenkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Mach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"\u0141ukasiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miko\u0142aj","family":"Olejniczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Logan W.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"W\u0119grzyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-0733","authenticated-orcid":true,"given":"Bo\u017cena","family":"Nejman-Fale\u0144czyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"pone.0296038.ref001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.50.1.355","article-title":"Escherichia coli O157:H7 gastroenteritis and the hemolytic uremic syndrome: an emerging infectious disease","volume":"50","author":"RE Besser","year":"1999","journal-title":"Annu Rev Med"},{"key":"pone.0296038.ref002","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0923-2508(01)01249-9","article-title":"Shiga-toxin-converting bacteriophages","volume":"152","author":"H. Schmidt","year":"2001","journal-title":"Res Microbiol"},{"key":"pone.0296038.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(04)79001-7","article-title":"Genetic switches during bacteriophage lambda development","volume":"79","author":"G W\u0119grzyn","year":"2005","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"pone.0296038.ref004","volume-title":"A Genetic Switch: Phage Lambda Revisited.","author":"M. Ptashne","year":"2004","edition":"3"},{"key":"pone.0296038.ref005","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0140-6736(99)00621-2","article-title":"Induction of type 2 Shiga toxin synthesis in Escherichia coli O157 by 4-quinolones","volume":"353","author":"PT Kimmitt","year":"1999","journal-title":"Lancet"},{"key":"pone.0296038.ref006","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3201\/eid0605.000503","article-title":"Toxin gene expression by shiga toxin-producing Escherichia coli: the role of antibiotics and the bacterial SOS response","volume":"6","author":"PT Kimmitt","year":"2000","journal-title":"Emerg Infect Dis"},{"key":"pone.0296038.ref007","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.micpath.2009.09.006","article-title":"Differential efficiency of induction of various lambdoid prophages responsible for production of Shiga toxins in response to different induction agents","volume":"47","author":"JM \u0141o\u015b","year":"2009","journal-title":"Microb Pathog"},{"key":"pone.0296038.ref008","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1574-695X.2009.00644.x","article-title":"Hydrogen peroxide-mediated induction of the Shiga toxin-converting lambdoid prophage ST2-8624 in Escherichia coli O157:H7","volume":"58","author":"JM \u0141o\u015b","year":"2010","journal-title":"FEMS Immunol Med Microbiol"},{"key":"pone.0296038.ref009","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/IAI.69.3.1934-1937.2001","article-title":"Human neutrophils and their products induce Shiga toxin production by enterohemorrhagic Escherichia coli","volume":"69","author":"PL Wagner","year":"2001","journal-title":"Infect Immun"},{"key":"pone.0296038.ref010","first-page":"211","article-title":"Plasmids derived from lambdoid bacteriophages as models for studying replication of mobile genetic elements responsible for the production of Shiga toxins by pathogenic Escherichia coli strains","volume":"17","author":"B Nejman","year":"2009","journal-title":"J Mol Microbiol Biotechnol"},{"key":"pone.0296038.ref011","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1099\/mic.0.042820-0","article-title":"Replication of plasmids derived from Shiga toxin-converting bacteriophages in starved Escherichia coli","volume":"157","author":"B Nejman","year":"2011","journal-title":"Microbiology (Reading)"},{"key":"pone.0296038.ref012","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1046\/j.1365-2958.2002.02950.x","article-title":"Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli","volume":"44","author":"PL Wagner","year":"2002","journal-title":"Mol Microbiol"},{"key":"pone.0296038.ref013","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mib.2005.06.001","article-title":"Phage regulatory circuits and virulence gene expression","volume":"8","author":"MK Waldor","year":"2005","journal-title":"Curr Opin Microbiol"},{"key":"pone.0296038.ref014","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.2527\/jas.2006-508","article-title":"Shiga toxin-producing Escherichia coli: an overview","volume":"85","author":"CL Gyles","year":"2007","journal-title":"J Anim Sci"},{"key":"pone.0296038.ref015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/oxfordjournals.epirev.a036079","article-title":"The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic syndrome","volume":"13","author":"PM Griffin","year":"1991","journal-title":"Epidemiol Rev"},{"key":"pone.0296038.ref016","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MOG.0b013e3282f2dfb8","article-title":"Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections","volume":"24","author":"A Serna","year":"2008","journal-title":"Curr Opin Gastroenterol"},{"key":"pone.0296038.ref017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jinf.2019.05.018","article-title":"Shiga toxin-induced haemolytic uraemic syndrome and the role of antibiotics: a global overview","volume":"79","author":"L Kakoullis","year":"2019","journal-title":"J Infect"},{"key":"pone.0296038.ref018","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/315239","article-title":"Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice","volume":"181","author":"X Zhang","year":"2000","journal-title":"J Infect Dis"},{"key":"pone.0296038.ref019","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/B978-0-12-394621-8.00016-9","article-title":"Phage \u03bb\u2014new insights into regulatory circuits","volume":"82","author":"G W\u0119grzyn","year":"2012","journal-title":"Adv Virus Res"},{"key":"pone.0296038.ref020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1101\/gad.1.2.197","article-title":"Control of gene expression in bacteriophage P22 by a small antisense RNA. I. Characterization in vitro of the Psar promoter and the sar RNA transcript","volume":"1","author":"SM Liao","year":"1987","journal-title":"Genes Dev"},{"key":"pone.0296038.ref021","first-page":"141","article-title":"Antisense RNA control of gene expression in bacteriophage P22. I. Structures of sar RNA and its target, ant mRNA","volume":"3","author":"KL Schaefer","year":"1997","journal-title":"RNA"},{"key":"pone.0296038.ref022","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1046\/j.1365-2958.1999.01658.x","article-title":"The anti-immunity system of phage-plasmid N15: identification of the antirepressor gene and its control by a small processed RNA","volume":"34","author":"NV Ravin","year":"1999","journal-title":"Mol Microbiol"},{"key":"pone.0296038.ref023","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1038\/srep10080","article-title":"A small, microRNA-size, ribonucleic acid regulating gene expression and development of Shiga toxin-converting bacteriophage \u03a624\u0392","volume":"5","author":"B Nejman-Fale\u0144czyk","year":"2015","journal-title":"Sci Rep"},{"key":"pone.0296038.ref024","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1128\/IAI.71.6.3409-3418.2003","article-title":"Immunity Profiles of Wild-Type and Recombinant Shiga-Like Toxin-Encoding Bacteriophages and Characterization of Novel Double Lysogens","volume":"71","author":"HE Allison","year":"2003","journal-title":"Infect Immun"},{"key":"pone.0296038.ref025","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1128\/jb.175.11.3401-3407.1993","article-title":"The Escherichia coli K-12 \u201cwild types\u201d W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels","volume":"175","author":"KF Jensen","year":"1993","journal-title":"J Bacteriol"},{"key":"pone.0296038.ref026","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00203-013-0920-8","article-title":"Genes from the exo\u2013xis region of \u03bb and Shiga toxin-converting bacteriophages influence lysogenization and prophage induction","volume":"195","author":"S Bloch","year":"2013","journal-title":"Arch Microbiol"},{"key":"pone.0296038.ref027","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1128\/AEM.00306-08","article-title":"Simple method for plating Escherichia coli bacteriophages forming very small plaques or no plaques under standard conditions","volume":"74","author":"JM \u0141o\u015b","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"pone.0296038.ref028","first-page":"1618","article-title":"Role of the Mysterious orf63 of \u03bb and Shiga Toxin-Converting \u03a624B Bacteriophages","volume":"8","author":"A Dydecka","year":"2017","journal-title":"Bad Phages in Good BacteriaFront Microbiol"},{"key":"pone.0296038.ref029","doi-asserted-by":"crossref","first-page":"e108233","DOI":"10.1371\/journal.pone.0108233","article-title":"Different Expression Patterns of Genes from the exo-xis Region of Bacteriophage \u03bb and Shiga Toxin-Converting Bacteriophage \u042424B following Infection or Prophage Induction in Escherichia coli","volume":"9","author":"S Bloch","year":"2014","journal-title":"PLOS ONE"},{"key":"pone.0296038.ref030","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/ppa.12157","article-title":"Isolation and characterization of novel soilborne lytic bacteriophages infecting Dickeya spp. biovar 3 (\u2018D. solani\u2019)","volume":"63","author":"R Czajkowski","year":"2014","journal-title":"Plant Pathology"},{"key":"pone.0296038.ref031","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1128\/IAI.00875-08","article-title":"Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7","volume":"76","author":"E Strauch","year":"2008","journal-title":"Infect Immun"},{"key":"pone.0296038.ref032","first-page":"8","article-title":"Transcriptomic and Metabolomics Profiling of Phage\u2013Host Interactions between Phage PaP1 and Pseudomonas aeruginosa","author":"X Zhao","year":"2017","journal-title":"Frontiers in Microbiology"},{"key":"pone.0296038.ref033","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","article-title":"NMRPipe: a multidimensional spectral processing system based on UNIX pipes","volume":"6","author":"F Delaglio","year":"1995","journal-title":"J Biomol NMR"},{"key":"pone.0296038.ref034","first-page":"7502","article-title":"Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein","volume":"48","author":"EM Stein","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"pone.0296038.ref035","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1021\/bi500741d","article-title":"Structure of bacterial regulatory RNAs determines their performance in competition for the chaperone protein Hfq","volume":"54","author":"EM Ma\u0142ecka","year":"2015","journal-title":"Biochemistry"},{"key":"pone.0296038.ref036","doi-asserted-by":"crossref","first-page":"W435","DOI":"10.1093\/nar\/gkx279","article-title":"IntaRNA 2.0: enhanced and customizable prediction of RNA-RNA interactions","volume":"45","author":"M Mann","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0296038.ref037","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-2105-11-129","article-title":"RNAstructure: software for RNA secondary structure prediction and analysis","volume":"11","author":"JS Reuter","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"pone.0296038.ref038","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nrmicro2615","article-title":"Hfq and its constellation of RNA","volume":"9","author":"J Vogel","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"pone.0296038.ref039","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fmolb.2020.00078","article-title":"RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria","volume":"7","author":"AP Quendera","year":"2020","journal-title":"Front Mol Biosci"},{"key":"pone.0296038.ref040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.adgen.2015.05.001","article-title":"Small RNAs in bacteria and archaea: who they are, what they do, and how they do it","volume":"90","author":"EGH Wagner","year":"2015","journal-title":"Adv Genet"},{"key":"pone.0296038.ref041","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/microbiolspec.RWR-0027-2018","article-title":"Cross-regulation between bacteria and phages at a post-transcriptional level","volume":"6","author":"S Altuvia","year":"2018","journal-title":"Microbiol Spectr"},{"key":"pone.0296038.ref042","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3390\/toxins9060181","article-title":"Small and Smaller\u2014sRNAs and MicroRNAs in the Regulation of Toxin Gene Expression in Prokaryotic Cells","volume":"9","author":"S Bloch","year":"2017","journal-title":"A Mini-Review. Toxins (Basel)"},{"key":"pone.0296038.ref043","doi-asserted-by":"crossref","first-page":"102527","DOI":"10.1016\/j.plasmid.2020.102527","article-title":"Bacteriophages as sources of small non-coding RNA molecules","volume":"113","author":"S Bloch","year":"2021","journal-title":"Plasmid"},{"key":"pone.0296038.ref044","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1128\/JVI.02007-14","article-title":"A Human Herpesvirus 6A-Encoded MicroRNA: Role in Viral Lytic Replication","volume":"89","author":"M Nukui","year":"2014","journal-title":"J Virol"},{"key":"pone.0296038.ref045","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3390\/v15020429","article-title":"miRNAs in Herpesvirus Infection: Powerful Regulators in Small Packages","volume":"15","author":"D Dass","year":"2023","journal-title":"Viruses"},{"key":"pone.0296038.ref046","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chom.2010.06.014","article-title":"Viral latency and its regulation: lessons from the gamma-herpesviruses","volume":"8","author":"SH Speck","year":"2010","journal-title":"Cell Host Microbe"},{"key":"pone.0296038.ref047","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mib.2017.10.014","article-title":"New aspects of RNA-based regulation by Hfq and its partner sRNAs","volume":"42","author":"DrK Kavita","year":"2017","journal-title":"Current opinion in microbiology"},{"key":"pone.0296038.ref048","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1261\/rna.031575.111","article-title":"The functional Hfq-binding module of bacterial sRNAs consists of a double or single hairpin preceded by a U-rich sequence and followed by a 3\u2032 poly(U) tail","volume":"18","author":"H Ishikawa","year":"2012","journal-title":"RNA"},{"key":"pone.0296038.ref049","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tig.2018.12.005","article-title":"miRNA Targeting: Growing beyond the Seed","volume":"35","author":"LB Chipman","year":"2019","journal-title":"Trends Genet"},{"key":"pone.0296038.ref050","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3390\/v14061215","article-title":"MicroRNA Regulation of Human Herpesvirus Latency","volume":"14","author":"S Chen","year":"2022","journal-title":"Viruses"},{"key":"pone.0296038.ref051","doi-asserted-by":"crossref","first-page":"32128","DOI":"10.1038\/srep32128","article-title":"The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo","volume":"6","author":"B Steer","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0296038.ref052","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.3390\/v6104005","article-title":"KSHV miRNAs Decrease Expression of Lytic Genes in Latently Infected PEL and Endothelial Cells by Targeting Host Transcription Factors","volume":"6","author":"K Plaisance-Bonstaff","year":"2014","journal-title":"Viruses"},{"key":"pone.0296038.ref053","first-page":"8","article-title":"Herpesviral microRNAs in Cellular Metabolism and Immune Responses","author":"H Kim","year":"2017","journal-title":"Frontiers in Microbiology"},{"key":"pone.0296038.ref054","doi-asserted-by":"crossref","first-page":"e1003018","DOI":"10.1371\/journal.ppat.1003018","article-title":"Virus-Encoded microRNAs: An Overview and a Look to the Future","volume":"8","author":"RP Kincaid","year":"2012","journal-title":"PLOS Pathogens"},{"key":"pone.0296038.ref055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2013.05.008","article-title":"EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma","volume":"436","author":"Y Ye","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0296038.ref056","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2011.08.004","article-title":"Serine metabolism: some tumors take the road less traveled","volume":"14","author":"RJ DeBerardinis","year":"2011","journal-title":"Cell Metab"},{"key":"pone.0296038.ref057","doi-asserted-by":"crossref","first-page":"e1004400","DOI":"10.1371\/journal.ppat.1004400","article-title":"Kaposi\u2019s Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected Cells","volume":"10","author":"O Yogev","year":"2014","journal-title":"PLOS Pathogens"},{"key":"pone.0296038.ref058","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation","volume":"324","author":"MG Vander Heiden","year":"2009","journal-title":"Science"},{"key":"pone.0296038.ref059","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3109\/14756366.2016.1140753","article-title":"Tumor metabolism, cancer cell transporters, and microenvironmental resistance","volume":"31","author":"KO Alfarouk","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"pone.0296038.ref060","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.044925","article-title":"The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model","volume":"13","author":"\u00c9 Sask\u0151i","year":"2020","journal-title":"Dis Model Mech"},{"key":"pone.0296038.ref061","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.3390\/cancers15102862","article-title":"Succinate-Directed Approaches for Warburg Effect-Targeted Cancer Management, an Alternative to Current Treatments?","volume":"15","author":"A Casas-Benito","year":"2023","journal-title":"Cancers (Basel)"},{"key":"pone.0296038.ref062","article-title":"Persistent Severe Hyperlactatemia and Metabolic Derangement in Lethal SDHB-Mutated Metastatic Kidney Cancer: Clinical Challenges and Examples of Extreme Warburg Effect","volume":"1","author":"C-H Lee","year":"2017","journal-title":"JCO Precis Oncol"},{"key":"pone.0296038.ref063","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/cge.13553","article-title":"Clinical implications of the oncometabolite succinate in SDHx-mutation carriers","volume":"97","author":"K Eijkelenkamp","year":"2020","journal-title":"Clinical Genetics"},{"key":"pone.0296038.ref064","doi-asserted-by":"crossref","first-page":"40424","DOI":"10.1038\/srep40424","article-title":"Shigatoxin encoding Bacteriophage \u03d524B modulates bacterial metabolism to raise antimicrobial tolerance","volume":"7","author":"GS Holt","year":"2017","journal-title":"Sci 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