{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:41:11Z","timestamp":1778600471393,"version":"3.51.4"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The infection caused by <jats:italic>Treponema pallidum<\/jats:italic> remains a severe public health problem, with a high prevalence in individuals over 60 years. However, research into infections such as syphilis continues to be neglected in geriatrics. This study aims to evaluate data on the detection rate of syphilis in Brazil, in individuals between 60 and 120 years, by characterizing the epidemiological profile and respective factors associated with it, in addition to performing a temporal trend analysis, from 2010 to 2020.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology<\/jats:title>\n<jats:p>Ecological, time-series study, which started with the collection of notifications from the database of the Information System on Compulsory Notification of Diseases. The epidemiological profile was characterized based on sociodemographic variables. The Statistical Package for the Social Sciences program, version 19.0, was used for incidence and prevalence analysis. The 2010 census by the Brazilian Institute of Geography and Statistics and projections for older people were considered. In the trend analysis, the <jats:italic>Joinpoint regression model<\/jats:italic> was used.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Main findings<\/jats:title>\n<jats:p>There was an upward variation in the detection of syphilis in older people from 2010 to 2018, with a peak in 2018. In 2019, there was a slight reduction in the notification of cases, which was accentuated in 2020. The prevalence of the infection was equivalent to 12.84 cases for each 100,000 Brazilians, with a mean age of 68.04 years (\u00b17.15) for those between 60 and 120 years, being higher in white and black males. The highest proportion of older people with syphilis occurred in the South and Southeast regions. However, the trend analysis showed a significant and homogeneous increase in all regions of Brazil, for both sexes and all age groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>There is a tendency for an increase in cases of syphilis in older people, which reinforces the need to plan health actions to combat the disease in this population.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0296481","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:38:02Z","timestamp":1725644282000},"page":"e0296481","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acquired syphilis in older people in Brazil from 2010\u20132020"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-5839","authenticated-orcid":true,"given":"Josiane Ara\u00fajo","family":"da Cunha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marquiony","family":"Marques dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenio","family":"Costa de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"issue":"5","key":"pone.0296481.ref001","first-page":"365","article-title":"Syphilis: An Old Disease with Present-Day Implications","volume":"77","author":"CJ McNeil","year":"2016","journal-title":"N C Med J"},{"issue":"7","key":"pone.0296481.ref002","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/ijd.13206","article-title":"Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations","volume":"55","author":"PJ Watts","year":"2016","journal-title":"Int J Dermatol"},{"issue":"5","key":"pone.0296481.ref003","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1590\/S0365-05962005000600017","article-title":"H\u00e1 100 anos, a descoberta do Treponema pallidum","volume":"80","author":"EM Souza","year":"2005","journal-title":"An Bras Dermatol"},{"issue":"Suppl 1","key":"pone.0296481.ref004","doi-asserted-by":"crossref","first-page":"e2020616","DOI":"10.1590\/0037-8682-616-2020","article-title":"Brazilian Protocol for Sexually Transmitted Infections 2020: acquired syphilis","volume":"54","author":"FLS Freitas","year":"2021","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"pone.0296481.ref005","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cnur.2020.06.009","article-title":"The Reemergence of Syphilis: Clinical Pearls for Consideration","volume":"55","author":"M McNamara","year":"2020","journal-title":"Nurs Clin North Am"},{"issue":"10398","key":"pone.0296481.ref006","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0140-6736(22)02348-0","article-title":"Syphilis","volume":"402","author":"RW Peeling","year":"2023","journal-title":"The Lancet"},{"key":"pone.0296481.ref007","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s13256-021-03153-1","article-title":"Gummatous neurosyphilis in an elderly patient in the Australian outback: a case report","volume":"15","author":"NA Devanand","year":"2021","journal-title":"J Med Case Rep"},{"key":"pone.0296481.ref008","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1590\/s1678-9946202163068","article-title":"Atypical presentation of secondary syphilis: annular lesions in an elderly patient","volume":"63","author":"DM Pagani","year":"2021","journal-title":"Rev Inst Med Trop"},{"key":"pone.0296481.ref009","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s12879-015-1209-0","article-title":"A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy","volume":"15","author":"AC Se\u00f1a","year":"2015","journal-title":"BMC Infect Dis"},{"issue":"24","key":"pone.0296481.ref010","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.3390\/jcm11247499","article-title":"Syphilis Infections, Reinfections and Serological Response in a Large Italian Sexually Transmitted Disease Centre: A Monocentric Retrospective Study","volume":"11","author":"V Marchese","year":"2022","journal-title":"J Clin Med"},{"key":"pone.0296481.ref011","unstructured":"World Health Organization. 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