{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:06:21Z","timestamp":1788303981867,"version":"build-2803163510"},"reference-count":11,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hematological markers such as eosinophil-to-lymphocyte (ELR), eosinophil-to-neutrophil (ENR), and eosinophil-to-monocyte (EMR) ratios may be used in the assessment of skin diseases. However, the relationship with vitiligo remains unclear.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>We investigated ELR, ENR, and EMR in vitiligo patients and the association with severe vitiligo.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study included patients of all ages diagnosed with vitiligo between 2005\u20132020. ELR, EMR, and ENR were calculated from complete blood counts within 30 days of the first recorded vitiligo diagnosis and 12\u201318 months before the vitiligo diagnosis. We evaluated the associations between ELR, ENR, and EMR and vitiligo.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>9,826 vitiligo patients (8,398 adults and 1,428 children) and 8,951 age and sex-matched controls were included in this study. We found that ELR, EMR, and ENR were higher in children than in adults. Patients with vitiligo had higher ENR and EMR than their matched controls. Patients with severe vitiligo had higher ELR, ENR, and EMR compared to patients with mild vitiligo. Patients with increased ENR and EMR 12\u201318 months before the vitiligo diagnosis had a higher chance of having severe vitiligo (ENR: OR = 7.40, p&lt;0.001, EMR: OR = 3.17, p&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>ELR, ENR, and EMR may be used in the assessment and prognosis of vitiligo, especially in severe cases.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0296626","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T18:28:18Z","timestamp":1707762498000},"page":"e0296626","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Determination of elevated eosinophil to lymphocyte ratio, eosinophil to neutrophil ratio, eosinophil to monocyte ratio and its association with severe vitiligo: A retrospective cohort study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5284-9805","authenticated-orcid":true,"given":"Sarah","family":"Weissmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitzan","family":"Burrack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-405X","authenticated-orcid":true,"given":"Inbal","family":"Golan-Tripto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-9061","authenticated-orcid":true,"given":"Amir","family":"Horev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"issue":"3","key":"pone.0296626.ref001","first-page":"473","article-title":"Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up","volume":"65","author":"A Alikhan","year":"2011","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"pone.0296626.ref002","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.det.2016.11.014","article-title":"Vitiligo Pathogenesis and Emerging Treatments.","volume":"35","author":"M Rashighi","year":"2017","journal-title":"Dermatol Clin."},{"key":"pone.0296626.ref003","first-page":"060","article-title":"Understanding the Role of Lymphocytes in Vitiligo.","volume":"8","author":"SS Awad","year":"2021","journal-title":"Int J Immunol Immunother"},{"key":"pone.0296626.ref004","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.3390\/ijms19103086","article-title":"New cytokines in the pathogenesis of atopic dermatitis-new therapeutic targets.","volume":"19","author":"J Klonowska","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"12","key":"pone.0296626.ref005","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.kjms.2015.10.010","article-title":"The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Beh\u00e7et\u2019s syndrome.","volume":"31","author":"S Alan","year":"2015","journal-title":"Kaohsiung J Med Sci"},{"key":"pone.0296626.ref006","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2017.00484","article-title":"Eosinophils in Autoimmune Diseases.","volume":"8","author":"NL Diny","year":"2017","journal-title":"Front Immunol."},{"issue":"5","key":"pone.0296626.ref007","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jaip.2016.03.020","article-title":"Hypereosinophilia in Children and Adults: A Retrospective Comparison","volume":"4","author":"KW Williams","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"7","key":"pone.0296626.ref008","doi-asserted-by":"crossref","first-page":"adv00491","DOI":"10.2340\/00015555-3838","article-title":"Role of eosinophil relative count and neutrophil-to-lymphocyte ratio in the assessment of severity of atopic dermatitis.","volume":"101","author":"S. Inokuchi-Sakata","year":"2021","journal-title":"Acta Dermato-Venereologica,"},{"key":"pone.0296626.ref009","article-title":"Decreased Eosinophil-Lymphocyte-Ratio, Eosinophil-Neutrophil-Ratio, and Eosinophil-Monocyte-Ratio in Chronic and Severe Urticaria.","author":"S Weissmann","year":"2023","journal-title":"American Journal of Clinical Dermatology"},{"key":"pone.0296626.ref010","doi-asserted-by":"crossref","first-page":"665827","DOI":"10.3389\/fneur.2021.665827","article-title":"Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis.","volume":"12","author":"H Cai","year":"2021","journal-title":"Front Neurol"},{"issue":"9","key":"pone.0296626.ref011","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1177\/0300060519862077","article-title":"New inflammatory indicators: association of high eosinophil-to-lymphocyte ratio and low lymphocyte-to-monocyte ratio with smoking","volume":"47","author":"Y \u00c7ekici","year":"2019","journal-title":"J Int Med Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0296626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T18:28:25Z","timestamp":1707762505000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0296626"}},"subtitle":[],"editor":[{"given":"M. Tanveer","family":"Hossain Parash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0296626","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]}}}