{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:28:46Z","timestamp":1783103326358,"version":"3.54.6"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC-112-2313-B-002-031"],"award-info":[{"award-number":["NSTC-112-2313-B-002-031"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study examined 70 <jats:italic>Klebsiella pneumoniae<\/jats:italic> isolates derived from companion animals with urinary tract infections in Taiwan. Overall, 81% (57\/70) of the isolates carried extended-spectrum \u03b2-lactamase (ESBL) and\/or plasmid-encoded AmpC (pAmpC) genes. ESBL genes were detected in 19 samples, with <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-1<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-9<\/jats:sub>, and <jats:italic>bla<\/jats:italic><jats:sub>SHV<\/jats:sub> being the predominant groups. pAmpC genes were detected in 56 isolates, with <jats:italic>bla<\/jats:italic><jats:sub>CIT<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>DHA<\/jats:sub> being the predominant groups. Multilocus sequence typing revealed that sequence types (ST)11, ST15, and ST655 were prevalent. <jats:italic>wabG<\/jats:italic>, <jats:italic>uge<\/jats:italic>, <jats:italic>entB<\/jats:italic>, <jats:italic>mrkD<\/jats:italic>, and <jats:italic>fimH<\/jats:italic> were identified as primary virulence genes. Two isolates demonstrated a hypermucoviscosity phenotype in the string test. Antimicrobial susceptibility testing exhibited high resistance to \u03b2-lactams and fluoroquinolones in ESBL-positive isolates but low resistance to aminoglycosides, sulfonamides, and carbapenems. Isolates carrying pAmpC genes exhibited resistance to penicillin-class \u03b2-lactams. These findings provide valuable insights into the role of <jats:italic>K<\/jats:italic>. <jats:italic>pneumoniae<\/jats:italic> in the context of the concept of One Health.<\/jats:p>","DOI":"10.1371\/journal.pone.0296709","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:26:56Z","timestamp":1705429616000},"page":"e0296709","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Occurrence and characteristics of extended-spectrum-\u03b2-lactamase- and pAmpC-producing Klebsiella pneumoniae isolated from companion animals with urinary tract infections"],"prefix":"10.1371","volume":"19","author":[{"given":"Megan Min Yi","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-6609","authenticated-orcid":true,"given":"Nan-Ling","family":"Kuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-7085","authenticated-orcid":true,"given":"Kuang-Sheng","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"issue":"1","key":"pone.0296709.ref001","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.UTI-0005-2012","article-title":"Epidemiology and virulence of Klebsiella pneumoniae","volume":"4","author":"S Clegg","year":"2016","journal-title":"Microbiol Spectr"},{"issue":"6","key":"pone.0296709.ref002","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/cid\/cir482","article-title":"Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae","volume":"53","author":"SY Won","year":"2011","journal-title":"Clin Infect Dis"},{"key":"pone.0296709.ref003","unstructured":"WHO. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. http:\/\/wwwwhoint\/medicines\/publications\/WHO-PPL-Short_Summary_25Feb-ET_NM_WHOpdf. 2017."},{"issue":"5","key":"pone.0296709.ref004","doi-asserted-by":"crossref","first-page":"e203951","DOI":"10.1001\/jamanetworkopen.2020.3951","article-title":"Comparative effectiveness of antibiotic treatment duration in children with pyelonephritis","volume":"3","author":"MT Fox","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"8","key":"pone.0296709.ref005","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.ajic.2011.05.004","article-title":"An effective intervention to limit the spread of an epidemic carbapenem-resistant Klebsiella pneumoniae strain in an acute care setting: from theory to practice","volume":"39","author":"P Ciobotaro","year":"2011","journal-title":"Am J Infect Control"},{"issue":"2","key":"pone.0296709.ref006","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cvsm.2018.11.005","article-title":"Urinary tract infection","volume":"49","author":"JK Byron","year":"2019","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"pone.0296709.ref007","first-page":"1162","article-title":"Therapeutic strategies involving antimicrobial treatment of the canine urinary tract","volume":"185","author":"GV Ling","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"pone.0296709.ref008","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fvets.2016.00070","article-title":"Health and behaviour survey of over 8000 finnish cats","volume":"3","author":"K Vapalahti","year":"2016","journal-title":"Front Vet Sci"},{"issue":"9","key":"pone.0296709.ref009","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1002\/vetr.60","article-title":"Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain","volume":"188","author":"L Darwich","year":"2021","journal-title":"Vet Rec"},{"key":"pone.0296709.ref010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","article-title":"Extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae: an emerging public-health concern","volume":"8","author":"JD Pitout","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"pone.0296709.ref011","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CMR.00036-08","article-title":"AmpC \u03b2-lactamase","volume":"22","author":"G. Jacoby","year":"2009","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"pone.0296709.ref012","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1128\/AAC.34.11.2200","article-title":"Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae","volume":"34","author":"GA Papanicolaou","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"pone.0296709.ref013","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF01650718","article-title":"Extended broad-spectrum beta-lactamase in Klebsiella pneumoniae including resistance to cephamycins","volume":"17","author":"A Bauernfeind","year":"1989","journal-title":"Infection"},{"issue":"2","key":"pone.0296709.ref014","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4161\/viru.22718","article-title":"Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: A new and dangerous breed","volume":"4","author":"AS Shon","year":"2013","journal-title":"Virulence"},{"issue":"3","key":"pone.0296709.ref015","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/MMBR.00078-15","article-title":"Klebsiella pneumoniae: going on the offense with a strong defense","volume":"80","author":"MK Paczosa","year":"2016","journal-title":"Microbiol Mol Biol Rev"},{"issue":"12","key":"pone.0296709.ref016","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1128\/JCM.02316-14","article-title":"Multiplex PCR for detection of seven virulence factors and K1\/K2 capsular serotypes of Klebsiella pneumoniae","volume":"52","author":"F Compain","year":"2014","journal-title":"J Clin Microbiol"},{"key":"pone.0296709.ref017","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcimb.2018.00004","article-title":"Colonization, Infection, and the accessory genome of Klebsiella pneumoniae","volume":"8","author":"RM Martin","year":"2018","journal-title":"Front Cell Infect Mi"},{"issue":"3","key":"pone.0296709.ref018","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/femsre\/fux013","article-title":"Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance","volume":"41","author":"S Navon-Venezia","year":"2017","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"pone.0296709.ref019","doi-asserted-by":"crossref","first-page":"e00001","DOI":"10.1128\/CMR.00001-19","article-title":"Hypervirulent Klebsiella pneumoniae","volume":"32","author":"TA Russo","year":"2019","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"pone.0296709.ref020","doi-asserted-by":"crossref","first-page":"e01537","DOI":"10.1128\/JCM.01537-18","article-title":"Evidence of sharing of Klebsiella pneumoniae strains between healthy companion animals and cohabiting humans","volume":"57","author":"C Marques","year":"2019","journal-title":"J Clin Microbiol"},{"issue":"10","key":"pone.0296709.ref021","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1093\/jac\/dku217","article-title":"Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses","volume":"69","author":"C Ewers","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"pone.0296709.ref022","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3389\/fmicb.2016.01021","article-title":"Phenotypic and molecular characterization of antimicrobial resistance in Klebsiella spp. Isolates from companion animals in Japan: clonal dissemination of multidrug-resistant extended-spectrum beta-lactamase-producing Klebsiella pneumoniae","volume":"7","author":"K Harada","year":"2016","journal-title":"Front Microbiol"},{"issue":"5","key":"pone.0296709.ref023","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1128\/AAC.04408-14","article-title":"Third-generation-cephalosporin-resistant Klebsiella pneumoniae isolates from humans and companion animals in Switzerland: spread of a DHA-producing Sequence Type 11 clone in a veterinary setting","volume":"59","author":"N Wohlwend","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"pone.0296709.ref024","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/fpd.2020.2847","article-title":"Klebsiella pneumoniae: prevalence, reservoirs, antimicrobial resistance, pathogenicity, and infection: a hitherto unrecognized zoonotic bacterium","volume":"18","author":"Y Hu","year":"2021","journal-title":"Foodborne Pathog Dis"},{"issue":"7","key":"pone.0296709.ref025","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1128\/JCM.36.7.1948-1952.1998","article-title":"Evaluation of the VITEK 2 system for rapid identification of medically relevant gram-negative rods","volume":"36","author":"G Funke","year":"1998","journal-title":"J Clin Microbiol"},{"key":"pone.0296709.ref026","unstructured":"CLSI. M-100, Performance Standards for Antimicrobial Susceptibility Testing, 30th ed. CLSI, Wayne, PA, USA. 2020."},{"key":"pone.0296709.ref027","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.vetmic.2010.01.018","article-title":"The role of class 1 and 2 integrons in mediating antimicrobial resistance among canine and feline clinical E. coli isolates from the US","volume":"144","author":"BW Shaheen","year":"2010","journal-title":"Vet Microbiol"},{"issue":"8","key":"pone.0296709.ref028","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1073\/pnas.75.8.3737","article-title":"Nucleotide-sequence of ampicillin resistance gene of Escherichia coli plasmid pBR322","volume":"75","author":"JG Sutcliffe","year":"1978","journal-title":"P Natl Acad Sci USA"},{"issue":"9","key":"pone.0296709.ref029","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1128\/JCM.43.9.4486-4491.2005","article-title":"Development of a multiplex PCR and SHV melting-curve mutation detection system for detection of some SHV and CTX-M beta-lactamases of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae in Taiwan","volume":"43","author":"JH Chia","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"1","key":"pone.0296709.ref030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jinf.2006.01.014","article-title":"Resistance of strains producing extended-spectrum beta-lactamases and genotype distribution in China","volume":"54","author":"Y Yu","year":"2007","journal-title":"J Infect"},{"key":"pone.0296709.ref031","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum \u03b2-lactamases","volume":"57","author":"N Woodford","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"pone.0296709.ref032","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1186\/s12879-014-0659-0","article-title":"Nationwide high prevalence of CTX-M and an increase of CTX-M-55 in Escherichia coli isolated from patients with community-onset infections in Chinese county hospitals","volume":"14","author":"J Zhang","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"6","key":"pone.0296709.ref033","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1128\/JCM.40.6.2153-2162.2002","article-title":"Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR","volume":"40","author":"FJ Perez-Perez","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"5","key":"pone.0296709.ref034","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1128\/AAC.05598-11","article-title":"Molecular characterization of extended-spectrum-beta-lactamase-producing and plasmid-mediated AmpC beta-lactamase-producing Escherichia coli isolated from stray dogs in South Korea","volume":"56","author":"MD Tamang","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"pone.0296709.ref035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diagmicrobio.2008.04.007","article-title":"Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1\/K2 and non-K1\/K2 serotypes","volume":"62","author":"WL Yu","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"4","key":"pone.0296709.ref036","doi-asserted-by":"crossref","first-page":"867","DOI":"10.18388\/abp.2015_1148","article-title":"Klebsiella pneumoniae: characteristics of carbapenem resistance and virulence factors","volume":"62","author":"ED Candan","year":"2015","journal-title":"Acta Biochim Pol"},{"issue":"10","key":"pone.0296709.ref037","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1086\/503420","article-title":"Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan","volume":"42","author":"WL Yu","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"5","key":"pone.0296709.ref038","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20030857","article-title":"A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications","volume":"199","author":"CT Fang","year":"2004","journal-title":"J Exp Med"},{"issue":"8","key":"pone.0296709.ref039","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","article-title":"Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates","volume":"43","author":"L Diancourt","year":"2005","journal-title":"J Clin Microbiol"},{"key":"pone.0296709.ref040","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jgar.2017.06.006","article-title":"Antimicrobial resistance profiles and genotypes of extended-spectrum beta-lactamase-and AmpC beta-lactamase-producing Klebsiella pneumoniae isolated from dogs in Beijing, China","volume":"10","author":"YH Liu","year":"2017","journal-title":"J Glob Antimicrob Re"},{"issue":"2","key":"pone.0296709.ref041","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.4142\/jvs.2021.22.e17","article-title":"Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals","volume":"22","author":"D Lee","year":"2021","journal-title":"J Vet Sci"},{"issue":"1\u20132","key":"pone.0296709.ref042","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetmic.2014.01.017","article-title":"Extended-spectrum beta-lactamase, carbapenemase and AmpC producing Enterobacteriaceae in companion animals","volume":"170","author":"JE Rubin","year":"2014","journal-title":"Vet Microbiol"},{"key":"pone.0296709.ref043","doi-asserted-by":"crossref","first-page":"36280","DOI":"10.1038\/srep36280","article-title":"The antimicrobial susceptibility of Klebsiella pneumoniae from community settings in Taiwan, a trend analysis","volume":"6","author":"WP Lin","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"pone.0296709.ref044","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1128\/AAC.50.5.1861-1864.2006","article-title":"Extended-spectrum beta-lactamases and plasmid-mediated AmpC enzymes among clinical isolates of Escherichia coli and Klebsiella pneumoniae from seven medical centers in Taiwan","volume":"50","author":"JJ Yan","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"pone.0296709.ref045","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1038\/s41467-021-24448-3","article-title":"A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex","volume":"12","author":"MMC Lam","year":"2021","journal-title":"Nat Commun"},{"key":"pone.0296709.ref046","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ebiom.2017.04.032","article-title":"Nationwide surveillance of clinical carbapenem-resistant Enterobacteriaceae (CRE) strains in China","volume":"19","author":"R Zhang","year":"2017","journal-title":"Ebiomedicine"},{"issue":"2","key":"pone.0296709.ref047","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1473-3099(16)30257-2","article-title":"Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study","volume":"17","author":"H Grundmann","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"14","key":"pone.0296709.ref048","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/jama.2015.12480","article-title":"Epidemiology of carbapenem-resistant Enterobacteriaceae in 7 US communities, 2012\u20132013","volume":"314","author":"AY Guh","year":"2015","journal-title":"JAMA"},{"issue":"2","key":"pone.0296709.ref049","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3201\/eid2602.190594","article-title":"Novel subclone of carbapenem-resistant Klebsiella pneumoniae sequence type 11 with enhanced virulence and transmissibility, China","volume":"26","author":"K Zhou","year":"2020","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"pone.0296709.ref050","doi-asserted-by":"crossref","first-page":"e01148","DOI":"10.1128\/AAC.01148-20","article-title":"Emerging antimicrobial-resistant high-risk Klebsiella pneumoniae clones ST307 and ST147","volume":"64","author":"G Peirano","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"pone.0296709.ref051","doi-asserted-by":"crossref","first-page":"105903","DOI":"10.1016\/j.ijantimicag.2020.105903","article-title":"KPC-2-producing Klebsiella pneumoniae ST147 in a neonatal unit: clonal isolates with differences in colistin susceptibility attributed to AcrAB-TolC pump","volume":"55","author":"S Naha","year":"2020","journal-title":"Int J Antimicrob Agents"},{"issue":"3","key":"pone.0296709.ref052","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/jac\/dky499","article-title":"Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes","volume":"74","author":"C Marques","year":"2019","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"pone.0296709.ref053","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ijmm.2014.08.003","article-title":"Expansion of ESBL-producing Klebsiella pneumoniae in hospitalized patients: a successful story of international clones (ST15, ST147, ST336) and epidemic plasmids (IncR, IncFIIK)","volume":"304","author":"C Rodrigues","year":"2014","journal-title":"Int J Med Microbiol"},{"issue":"3","key":"pone.0296709.ref054","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1017\/S0950268816002442","article-title":"Outbreak of KPC-3-producing ST15 and ST348 Klebsiella pneumoniae in a Portuguese hospital","volume":"145","author":"D Vubil","year":"2017","journal-title":"Epidemiol Infect"},{"issue":"3","key":"pone.0296709.ref055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1142\/S1682648515500274","article-title":"Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from the urine of dogs and cats suspected of urinary tract infection in a veterinary teaching hospital","volume":"42","author":"NL Kuan","year":"2016","journal-title":"Taiwan Vet J"},{"key":"pone.0296709.ref056","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.vetmic.2018.02.020","article-title":"Prevalence of ESBL\/AmpC genes and specific clones among the third-generation cephalosporin-resistant Enterobacteriaceae from canine and feline clinical specimens in Japan","volume":"216","author":"Y Maeyama","year":"2018","journal-title":"Vet Microbiol"},{"issue":"5","key":"pone.0296709.ref057","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1128\/AAC.02622-12","article-title":"Extended-spectrum beta-lactamase CTX-M-15-producing Klebsiella pneumoniae of sequence type ST274 in companion animals","volume":"57","author":"L Poirel","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"pone.0296709.ref058","doi-asserted-by":"crossref","first-page":"e90564","DOI":"10.1371\/journal.pone.0090564","article-title":"Extended-spectrum-beta-lactamases, AmpC beta-lactamases and plasmid mediated quinolone resistance in Klebsiella spp. from companion animals in Italy","volume":"9","author":"V Donati","year":"2014","journal-title":"PLoS ONE"},{"issue":"1","key":"pone.0296709.ref059","doi-asserted-by":"crossref","first-page":"13791","DOI":"10.1038\/s41598-022-17996-1","article-title":"Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospitals reveals insights into circulating antimicrobial resistance","volume":"12","author":"A Spadar","year":"2022","journal-title":"Sci Rep"},{"key":"pone.0296709.ref060","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mib.2018.04.004","article-title":"Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria","volume":"45","author":"KL Wyres","year":"2018","journal-title":"Curr Opin Microbiol"},{"issue":"12","key":"pone.0296709.ref061","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1128\/jb.177.12.3518-3526.1995","article-title":"Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA","volume":"177","author":"JL Huie","year":"1995","journal-title":"J Bacteriol"},{"key":"pone.0296709.ref062","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3389\/fmicb.2020.00700","article-title":"Resistance of Klebsiella pneumoniae strains carrying blaNDM-1 gene and the genetic environment of blaNDM-1","volume":"11","author":"TX Xiang","year":"2020","journal-title":"Front Microbiol"},{"issue":"1","key":"pone.0296709.ref063","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12866-020-01825-4","article-title":"Effect of donor-recipient relatedness on the plasmid conjugation frequency: a meta-analysis","volume":"20","author":"JB Alderliesten","year":"2020","journal-title":"BMC Microbiol"},{"key":"pone.0296709.ref064","doi-asserted-by":"crossref","first-page":"738223","DOI":"10.3389\/fcimb.2021.738223","article-title":"Antibiotic resistance and virulence profiles of Klebsiella pneumoniae strains isolated from different clinical sources","volume":"11","author":"V Ballen","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"pone.0296709.ref065","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/ijmm.IJMM_19_157","article-title":"Characterisation of virulence genes associated with pathogenicity in Klebsiella pneumoniae","volume":"37","author":"PA Remya","year":"2019","journal-title":"Indian J Med Microbiol"},{"issue":"2","key":"pone.0296709.ref066","first-page":"98","article-title":"Virulence characterization of Klebsiella pneumoniae and its relation with ESBL and AmpC beta-lactamase associated resistance","volume":"12","author":"E Soltani","year":"2020","journal-title":"Iran J Microbiol"},{"key":"pone.0296709.ref067","doi-asserted-by":"crossref","first-page":"783523","DOI":"10.3389\/fmicb.2022.783523","article-title":"Multicenter surveillance of capsular serotypes, virulence genes, and antimicrobial susceptibilities of Klebsiella pneumoniae causing bacteremia in Taiwan, 2017\u20132019","volume":"13","author":"CH Liao","year":"2022","journal-title":"Front Microbiol"},{"issue":"11","key":"pone.0296709.ref068","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1128\/JCM.01076-06","article-title":"Emergence and outbreaks of CTX-M beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae strains in a Tunisian hospital","volume":"44","author":"K Mamlouk","year":"2006","journal-title":"J Clin Microbiol"},{"issue":"9","key":"pone.0296709.ref069","doi-asserted-by":"crossref","first-page":"e00776","DOI":"10.1128\/JCM.00776-18","article-title":"Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae","volume":"56","author":"TA Russo","year":"2018","journal-title":"J Clin Microbiol"},{"issue":"5","key":"pone.0296709.ref070","doi-asserted-by":"crossref","first-page":"e0124222","DOI":"10.1128\/spectrum.01242-22","article-title":"Limited transmission of Klebsiella pneumoniae among humans, animals, and the environment in a Caribbean island, Guadeloupe (French West Indies)","volume":"10","author":"A Dereeper","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"3","key":"pone.0296709.ref071","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/pathogens10030271","article-title":"Molecular Investigation of Klebsiella pneumoniae from clinical companion animals in Beijing, China, 2017\u20132019","volume":"10","author":"ZB Zhang","year":"2021","journal-title":"Pathogens"},{"key":"pone.0296709.ref072","doi-asserted-by":"crossref","first-page":"816415","DOI":"10.3389\/fvets.2022.816415","article-title":"Multidrug-resistant Klebsiella pneumoniae complex from clinical dogs and cats in China: molecular characteristics, phylogroups, and hypervirulence-associated determinants","volume":"9","author":"ZB Zhang","year":"2022","journal-title":"Front Vet Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0296709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:27:30Z","timestamp":1705429650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0296709"}},"subtitle":[],"editor":[{"given":"Nabi","family":"Jomehzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0296709","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}