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Intracranial compliance plays a significant role in maintaining cerebral blood flow, cerebral perfusion pressure, and intracranial pressure. This study\u2019s objective was to investigate the feasibility of transferring external pressure into the eye orbit in a large-animal model while maintaining a clinically acceptable pressure gradient between intraorbital and external pressures. The experimental system comprised a specifically designed pressure applicator that can be placed and tightly fastened onto the eye. A pressure chamber made from thin, elastic, non-allergenic film was attached to the lower part of the applicator and placed in contact with the eyelid and surrounding tissues of piglets\u2019 eyeballs. External pressure was increased from 0 to 20 mmHg with steps of 1 mmHg, from 20 to 30 mmHg with steps of 2 mmHg, and from 30 to 50 mmHg with steps of 5 mmHg. An invasive pressure sensor was used to measure intraorbital pressure directly. An equation was derived from measured intraorbital and external pressures (intraorbital pressure = 0.82 \u00d7 external pressure + 3.12) and demonstrated that external pressure can be linearly transferred to orbit tissues with a bias (systematic error) of 3.12 mmHg. This is close to the initial intraorbital pressure within the range of pressures tested. We determined the relationship between intraorbital compliance and externally applied pressure. Our findings indicate that intraorbital compliance can be controlled across a wide range of 1.55 to 0.15 ml\/mmHg. We observed that external pressure transfer into the orbit can be achieved while maintaining a clinically acceptable pressure gradient between intraorbital and external pressures.<\/jats:p>","DOI":"10.1371\/journal.pone.0296780","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:27:50Z","timestamp":1705084070000},"page":"e0296780","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraorbital pressure\u2013volume characteristics in a piglet model: In vivo pilot study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-5068","authenticated-orcid":true,"given":"Yasin","family":"Hamarat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laimonas","family":"Bartusis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Putnynaite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolandas","family":"Zakelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mantas","family":"Deimantavicius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Zigmantaite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramun\u0117","family":"Grigaleviciute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrius","family":"Kucinskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaldas","family":"Kalvaitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arminas","family":"Ragauskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"pone.0296780.ref001","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/jnnp.2003.033126","article-title":"Monitoring and interpretation of intracranial pressure","volume":"75","author":"M Czosnyka","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"pone.0296780.ref002","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/bja\/ael110","article-title":"Monitoring the injured brain: ICP and CBF","volume":"97","author":"LA Steiner","year":"2006","journal-title":"Br J Anaesth"},{"key":"pone.0296780.ref003","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1038\/s41598-021-83777-x","article-title":"Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study","volume":"11","author":"P Lucinskas","year":"2021","journal-title":"Sci Rep"},{"key":"pone.0296780.ref004","doi-asserted-by":"crossref","first-page":"e0164263","DOI":"10.1371\/journal.pone.0164263","article-title":"The Intracranial Volume Pressure Response in Increased Intracranial Pressure Patients: Clinical Significance of the Volume Pressure Indicator","volume":"11","author":"H-Y Lai","year":"2016","journal-title":"PLoS One"},{"key":"pone.0296780.ref005","doi-asserted-by":"crossref","first-page":"22013","DOI":"10.1038\/s41598-020-78880-4","article-title":"An update to the Monro-Kellie doctrine to reflect tissue compliance after severe ischemic and hemorrhagic stroke","volume":"10","author":"ACJ Kalisvaart","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0296780.ref006","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1089\/neu.2011.2018","article-title":"Continuous monitoring of the Monro-Kellie doctrine: is it possible?","volume":"29","author":"D-J Kim","year":"2012","journal-title":"J Neurotrauma"},{"key":"pone.0296780.ref007","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1177\/0271678X16648711","article-title":"Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure","volume":"36","author":"MH Wilson","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"pone.0296780.ref008","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1212\/WNL.56.12.1746","article-title":"The Monro-Kellie hypothesis: applications in CSF volume depletion","volume":"56","author":"B. 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