{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:09:33Z","timestamp":1787501373717,"version":"build-2736575974"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Provincial Major Scientific and Technological Special Projects on Health","award":["NO. 2022ZD01008"],"award-info":[{"award-number":["NO. 2022ZD01008"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    The purpose of this study was to look at any connections that could exist between neutrophil-lymphocyte ratio and coronary heart disease. We performed a cross-sectional research of 13732 participants in the National Health and Nutrition Examination Survey who were 40 or older. Multivariate logistic regression models investigated the relationship between neutrophil-to-lymphocyte ratio levels and coronary heart disease risk. To investigate potential nonlinear connections, smoothed curve fitting was used. When a nonlinear relationship was discovered, the inflexion point was determined using a recursive method. After controlling for relevant confounders, neutrophil-to-lymphocyte ratio was independently linked to a higher risk of coronary heart disease (OR = 1.74, 95% CI:1.30\u20132.33,\n                    <jats:bold>\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:bold>\n                    = 0.0002). Subgroup analyses showed statistically significant positive associations between neutrophil-to-lymphocyte ratio and coronary heart disease risk in women (OR = 1.25, 95% CI:1.09\u20131.43), participants 60 years of age and older (OR = 1.09, 95% CI:1.00\u20131.19), smoking status for every day or not at all (OR = 1.23, 95% CI:1.00\u20131.52; OR = 1.09, 95% CI:1.00\u20131.19), alcohol use status for moderate alcohol use (OR = 1.11, 95% CI:1.00\u20131.22), body mass index &gt;30 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (OR = 1.42, 95% CI:1.10\u20131.82), hypertensive (OR = 1.11, 95% CI:1.02\u20131.22), and individuals without diabetes (OR = 1.17, 95% CI:1.06\u20131.31). A positive correlation between neutrophil-to-lymphocyte ratio levels and coronary heart disease risk was also seen by smoothing curve fitting, with an inflexion point of 1.08 that was statistically significant (\n                    <jats:bold>\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:bold>\n                    &lt;0.05). Our research shows elevated neutrophil-to-lymphocyte ratio levels are linked to a higher risk of coronary heart disease.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0296838","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T13:25:00Z","timestamp":1707830700000},"page":"e0296838","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["The neutrophil-to-lymphocyte ratio is associated with coronary heart disease risk in adults: A population-based study"],"prefix":"10.1371","volume":"19","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangping","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsha","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7216-9282","authenticated-orcid":true,"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"pone.0296838.ref001","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1016\/j.jacc.2020.11.021","article-title":"The 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