{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:32:42Z","timestamp":1787740362783,"version":"build-2784847793"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011893","name":"Pan-American Health Organization","doi-asserted-by":"crossref","award":["INCA\/PAHO TC 43 agreement"],"award-info":[{"award-number":["INCA\/PAHO TC 43 agreement"]}],"id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021671","name":"Brazilian National Cancer Institute","doi-asserted-by":"crossref","award":["institutional development scholarship"],"award-info":[{"award-number":["institutional development scholarship"]}],"id":[{"id":"10.13039\/501100021671","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","award":["Scientific research\/initiation scholarship"],"award-info":[{"award-number":["Scientific research\/initiation scholarship"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","award":["Scientific research\/initiation scholarship"],"award-info":[{"award-number":["Scientific research\/initiation scholarship"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CNPQ\/INCA","award":["Scientific research\/initiation scholarship"],"award-info":[{"award-number":["Scientific research\/initiation scholarship"]}]},{"name":"CNPQ\/INCA","award":["Scientific research\/initiation scholarship"],"award-info":[{"award-number":["Scientific research\/initiation scholarship"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Non-Hodgkin\u2019s Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence curve. Occupational exposures to chemical, biological, and physical agents have also been associated with NHL development, but the results are still controversial. We have investigated the occupational and lifestyle case-control study design with 214 adult patients and 452 population controls. Socio-demographic, clinical, and occupational exposure data were obtained through individual interviews with a standardized questionnaire. Clinical, laboratory, and histopathological data were obtained through medical records. Risk of NHL (any subtype), B-cell lymphoma, DLBCL, Follicular lymphoma and T-cell lymphoma was elevated among the those who had ever been exposed to <jats:bold><jats:italic>any solvents<\/jats:italic><\/jats:bold>, <jats:bold><jats:italic>hydrocarbon solvents<\/jats:italic><\/jats:bold>, <jats:bold><jats:italic>pesticides<\/jats:italic><\/jats:bold>, <jats:bold><jats:italic>meat and meat products<\/jats:italic><\/jats:bold>, and <jats:bold><jats:italic>sunlight<\/jats:italic><\/jats:bold> and tended to increase by years of exposure. A significant upward trend with years of exposure was detected for <jats:bold><jats:italic>any solvents<\/jats:italic><\/jats:bold> and <jats:bold><jats:italic>hydrocarbon solvents<\/jats:italic><\/jats:bold> (NHL (any subtype) p-value for trend&lt;0.001), B-cell lymphoma (p-value for trend&lt;0.001), and T-cell lymphoma (p-value for trend&lt;0.023), <jats:bold><jats:italic>pesticides<\/jats:italic><\/jats:bold> (NHL (any subtype), p for trend&lt;0.001) and T-cell lymphoma (p for trend&lt;0.002), <jats:bold><jats:italic>meat and meat products<\/jats:italic><\/jats:bold> (NHL (any subtype) (p for trend&lt;0.001) and DLBCL (p for trend&lt;0.001), and <jats:bold><jats:italic>sunlight<\/jats:italic><\/jats:bold> (B-cell lymphoma (p for trend&lt;0.001). The results of this study agree line with other international studies, can be extrapolated to other countries that have the same socio-demographic and occupational characteristics as Brazil and support strategies for surveillance and control of work-related cancer.<\/jats:p>","DOI":"10.1371\/journal.pone.0297140","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T18:22:53Z","timestamp":1708971773000},"page":"e0297140","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of occupational risk factors for the development of non-Hodgkin\u2019s lymphoma in adults: A hospital-based case-control study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-4653","authenticated-orcid":true,"given":"Marcia","family":"Sarpa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa \u00cdndio do Brasil","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-1818","authenticated-orcid":true,"given":"S\u00e2mila Natiane","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina \u00c1vila","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Gabriela Sousa","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Vargas","family":"de Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur O. 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