{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:49:46Z","timestamp":1791985786099,"version":"4.4.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The study aimed to compare the 12-month post-operative outcomes of iStent and iStent inject W (inject W), and the factors associated with their success in open-angle glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center, retrospective comparative case series evaluated the medical records of patients who underwent iStent (comprising 1 stent) or inject W (comprising 2 stents) implantation with cataract surgery for primary open-angle glaucoma and normal tension glaucoma between January 2019 and March 2022. The 12-month post-operative efficacy outcomes included intraocular pressure (IOP), glaucoma medications, and survival analysis of the probability of success. \u201cFailure\u201d was defined as any of the following conditions compared to baseline: 1) IOP elevation, 2) increased glaucoma medication, or 3) IOP decline not exceeding 20% when glaucoma medication scores were comparable, and 4) need for additional glaucoma surgery. The safety outcomes included intra- and post-operative adverse events and changes in the best-corrected visual acuity and visual field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study comprised 55 eyes in the iStent and 105 in the inject W groups. At 12 months, treatment success was achieved in 66.0% of iStent and 78.4% of inject W eyes. The mean IOP was lower, and the percent reduction from baseline was equal in iStent-treated eyes (8.0% reduction, 14.8 mmHg to 13.7 mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) and inject W-treated eyes (11.9% reduction, 15.0 mmHg to 13.8 mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) (between-group comparison,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.23). The mean medication burden decreased significantly from 2.5 to 1.1 for iStent (55.0% reduction,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) and 2.9 to 1.7 for iStent inject (46.8% reduction,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), with no significant differences between the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.17). Both devices exhibited excellent safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both devices significantly reduced IOP and glaucoma medication 12 months post-operatively. The outcome measures did not differ significantly between the two groups, and lower baseline IOP was predictive of surgical failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0297514","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T13:26:54Z","timestamp":1707139614000},"page":"e0297514","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparative evaluation of iStent versus iStent inject W combined with phacoemulsification in open angle glaucoma"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-377X","authenticated-orcid":true,"given":"Shuu","family":"Morita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-0165","authenticated-orcid":true,"given":"Yoshihito","family":"Sakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikari","family":"Riyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Ebihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"pone.0297514.ref001","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"YC Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"pone.0297514.ref002","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis","volume":"5","author":"SR Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"pone.0297514.ref003","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10384-018-0623-4","article-title":"Incidence and causes of visual impairment in Japan: the first nation-wide complete enumeration survey of newly certified visually impaired individuals","volume":"63","author":"Y Morizane","year":"2019","journal-title":"Jpn J Ophthalmol"},{"key":"pone.0297514.ref004","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0002-9394(89)90221-3","article-title":"Intraocular pressure and glaucoma","volume":"107","author":"A. 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