{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:06:57Z","timestamp":1773068817001,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023174","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","doi-asserted-by":"publisher","award":["NKB-1099\/UN2.RST\/HKP.05.00\/2023"],"award-info":[{"award-number":["NKB-1099\/UN2.RST\/HKP.05.00\/2023"]}],"id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023174","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","doi-asserted-by":"publisher","award":["NKB-1099\/UN2.RST\/HKP.05.00\/2023"],"award-info":[{"award-number":["NKB-1099\/UN2.RST\/HKP.05.00\/2023"]}],"id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Celiac disease (CD) is an autoimmune disease of the small intestine triggered by the consumption of gluten-containing foods in individuals with a genetic predisposition. CD was a rare disease until 20 years ago, when the prevalence increased. Currently, there is no data on the prevalence of CD in high-risk adult populations in Indonesia, even though there is a trend of increasing gluten consumption. Therefore, basic research is needed to determine the magnitude of CD in high-risk adult patients in Indonesia while identifying clinical signs\/symptoms, illness history, and lifestyle to determine factors associated with CD in Indonesia. This study is an observational study with a cross-sectional method.Two hundred eighty-three patients who fulfilled the selection and signed the informed consent were recruited from the gastroenterology clinic of Dr. Cipto Mangunkusumo General Hospital. Patients were asked to fill out a celiac disease-related questionnaire and then given anthropometry measurement and blood test for serologic examination with ELISA, consisting of IgA anti-tissue transglutaminase (anti-TTG) and IgG anti-deaminated gliadin peptide (anti-DGP). Statistical analysis was performed using Chi-square and Multivariate logistic regression tests with SPSS software ver. 26. Statistical test differences were considered significant if the p-values were &lt; 0.05. Eight of 283 patients are serologically confirmed with CD (2,83%). On bivariate analysis, the significant variables are age (p &lt; 0,05), constipation (p &lt; 0,05) and history of autoimmune disease (p &lt; 0,05). On multivariate analysis, the only significant variable is the history of autoimmune disease (p &lt; 0,05). This study concluded that the prevalence of CD in high-risk patients with functional gastrointestinal disorder at Dr. Cipto Mangunkusumo Hospital is relatively high (2.83%). CD-associated factors are age, constipation, and history of autoimmune disease in patients. On simultaneous interaction between these factors, autoimmune is the only significant variable associated with CD.<\/jats:p>","DOI":"10.1371\/journal.pone.0297605","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T14:07:32Z","timestamp":1717769252000},"page":"e0297605","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and factors associated with celiac disease in high-risk patients with functional gastrointestinal disorders"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-3553","authenticated-orcid":true,"given":"Ari Fahrial","family":"Syam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Pitarini","family":"Utari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Hamidah","family":"Hasanah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almaarif","family":"Rizky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murdani","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"pone.0297605.ref001","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","volume":"16","author":"P Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"pone.0297605.ref002","first-page":"1","article-title":"Celiac disease.","author":"JC Bai","year":"2016","journal-title":"World Gastroenterology Organisation Global Guidelines"},{"key":"pone.0297605.ref003","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"JF Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"pone.0297605.ref004","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/MPG.0b013e31824703c7","article-title":"Diagnostic value of anti- deamidated gliadin peptide IgG antibodies for celiac disease in children and IgA-deficient patients","volume":"1","author":"L Mozo","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"pone.0297605.ref005","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/jgh.12514","article-title":"Issues associated with the emergence of coeliac disease in the Asia-Pacific region: A working party report of the World Gastroenterology Organization and the Asia Pacific Association of Gastroenterology","volume":"29","author":"GK Makharia","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"pone.0297605.ref006","first-page":"231","article-title":"Celiac disease at several hospitals in Jakarta, Indonesia","volume":"4","author":"M. 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Antibiotic exposure and the development of the coeliac disease: a nationwide case\u2013control study","volume":"19","author":"K Marild","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"pone.0297605.ref026","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1503\/cmaj.051351","article-title":"Health benefits of physical activity: the evidence","volume":"6","author":"D. E. Warburton","year":"2006","journal-title":"Canadian Medical Association Journal"},{"key":"pone.0297605.ref027","first-page":"354","article-title":"Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose\u2013response meta-analysis for the Global Burden of Disease Study 2013.","volume":"i","author":"H. H. 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