{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:54:55Z","timestamp":1783464895461,"version":"3.55.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Presence of left atrial (LA) fibrosis reflects underlying atrial cardiomyopathy. Interatrial block (IAB) is associated with LA fibrosis in patients with atrial fibrillation (AF). The association of IAB and LA fibrosis in the patients without history of AF is unknown. We examined association of IAB and LA fibrosis in the patients without AF history. This is a retrospective analysis of 229 patients undergoing cardiac magnetic resonance imaging (CMR). LA fibrosis was reported from spatial extent of late gadolinium enhancement of CMR. IAB was measured from 12-lead electrocardiography using digital caliper. Of 229 patients undergoing CMR, prevalence of IAB was 50.2%. Patients with IAB were older (56.9\u00b113.9 years vs. 45.9\u00b119.2 years, p&lt;0.001) and had higher prevalence of co-morbidities. Left ventricular ejection fraction was lower in IAB group. LA volume index (LAVI) was greater in IAB group (54.6\u00b124.9 ml\/m<jats:sup>2<\/jats:sup>vs. 43.0\u00b121.1 ml\/m<jats:sup>2<\/jats:sup>, p&lt;0.001). Patients with IAB had higher prevalence of LA fibrosis than those without IAB (70.4% vs. 21.2%; p&lt;0.001). After multivariable analysis, only IAB and LAVI were independent factors that predict LA fibrosis. Prevalence of IAB in patients undergoing CMR was high. IAB was highly associated with LA fibrosis and larger LA size in patients without AF history.<\/jats:p>","DOI":"10.1371\/journal.pone.0297920","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T18:27:55Z","timestamp":1707416875000},"page":"e0297920","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of the interatrial block and left atrial fibrosis in the patients without history of atrial fibrillation"],"prefix":"10.1371","volume":"19","author":[{"given":"Arintaya","family":"Phrommintikul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natnicha","family":"Pongbangli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriluck","family":"Gunaparn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narawudt","family":"Prasertwitayakij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerapat","family":"Nantsupawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-329X","authenticated-orcid":true,"given":"Wanwarang","family":"Wongcharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"issue":"4","key":"pone.0297920.ref001","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.joa.2016.05.002","article-title":"EHRA\/HRS\/APHRS\/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication.","volume":"32","author":"A Goette","year":"2016","journal-title":"J Arrhythm"},{"key":"pone.0297920.ref002","first-page":"8","author":"Y Ning","year":"2021","journal-title":"Atrial Cardiomyopathy: An Emerging Cause of the Embolic Stroke of Undetermined Source."},{"issue":"2","key":"pone.0297920.ref003","first-page":"e002769","volume":"8","author":"M Habibi","year":"2015","journal-title":"Association of Left Atrial Function and Left Atrial Enhancement in Patients With Atrial Fibrillation"},{"issue":"2","key":"pone.0297920.ref004","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jacc.2004.10.035","article-title":"Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: An independent predictor of procedural failure","volume":"45","author":"A Verma","year":"2005","journal-title":"Journal of the American College of Cardiology"},{"issue":"2","key":"pone.0297920.ref005","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0008-6363(02)00251-1","article-title":"Determinants and consequences of atrial fibrosis in patients undergoing open heart surgery","volume":"54","author":"A Goette","year":"2002","journal-title":"Cardiovascular Research"},{"issue":"4","key":"pone.0297920.ref006","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1212\/WNL.0000000000007827","article-title":"Embolic stroke of undetermined source correlates to atrial fibrosis without atrial fibrillation","volume":"93","author":"K Tandon","year":"2019","journal-title":"Neurology"},{"issue":"1","key":"pone.0297920.ref007","first-page":"14","article-title":"Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers. 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