{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:29:53Z","timestamp":1794018593777,"version":"4.8.0"},"reference-count":107,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    For the first time since 2015, the World Health Organization\u2019s (WHO) global Antimicrobial Resistance and Use Surveillance (GLASS) featured both global reports for antimicrobial resistance (AMR) and antimicrobial consumption (AMC) data in its annual reports. In this study we investigated the relationship of AMR with AMC within participating countries reported in the GLASS 2022 report. Our analysis found a statistically significant correlation between beta-lactam\/cephalosporin and fluoroquinolones consumption and AMR to these antimicrobials associated with bloodstream\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    and\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    among the participating countries (P&lt;0.05). We observed that for every 1 unit increase in defined daily dose DDD of beta-lactam\/cephalosporins and quinolone consumptions among the countries, increased the recoveries of bloodstream-associated beta-lactam\/cephalosporins-resistant\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    \/\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    spp. by 11\u201322% and quinolone-resistant\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    \/\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    spp. by 31\u201340%. When we compared the antimicrobial consumptions between the antimicrobial ATC (Alphanumeric codes developed by WHO) groups and countries, we observed a statistically significant higher daily consumption of beta-lactam-penicillins (J01C, DDD difference range: 5.23\u20138.13) and cephalosporins (J01D, DDD difference range: 2.57\u20135.13) compared to other antimicrobial groups among the countries (adjusted for multiple comparisons using Tukey\u2019s method). Between the participating countries, we observed a statistically significant higher daily consumption of antimicrobial groups in Iran (DDD difference range: 3.63\u20134.84) and Uganda (DDD difference range: 3.79\u20135.01) compared to other participating countries (adjusted for multiple comparisons using Tukey\u2019s method). Understanding AMC and how it relates to AMR at the global scale is critical in the global AMR policy development and implementation of global antimicrobial stewardship.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0297921","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T13:31:50Z","timestamp":1707139910000},"page":"e0297921","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":290,"title":["Global antimicrobial resistance and use surveillance system (GLASS 2022): Investigating the relationship between antimicrobial resistance and antimicrobial consumption data across the participating countries"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3152-6518","authenticated-orcid":true,"given":"Samuel","family":"Ajulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-6515","authenticated-orcid":true,"given":"Babafela","family":"Awosile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"issue":"10325","key":"pone.0297921.ref001","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"CJL Murray","year":"2022","journal-title":"The Lancet"},{"key":"pone.0297921.ref002","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.2147\/IDR.S234610","article-title":"Antimicrobial Resistance: Implications and Costs","volume":"12","author":"P. Dadgostar","year":"2019","journal-title":"Infect Drug Resist"},{"key":"pone.0297921.ref003","author":"ON Jim","year":"2016","journal-title":"Tackling drug-resistant infections globally: final report and recommendations"},{"issue":"Supplement_1","key":"pone.0297921.ref004","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1093\/cid\/ciaa1581","article-title":"National Estimates of Healthcare Costs Associated With Multidrug-Resistant Bacterial Infections Among Hospitalized Patients in the United States","volume":"72","author":"RE Nelson","year":"2021","journal-title":"Clinical Infectious Diseases"},{"key":"pone.0297921.ref005","doi-asserted-by":"crossref","unstructured":"Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. 2019. https:\/\/dx.doi.org\/10.15620\/cdc:82532. cdc:82532.","DOI":"10.15620\/cdc:82532"},{"key":"pone.0297921.ref006","doi-asserted-by":"crossref","DOI":"10.1596\/26707","volume-title":"Drug-Resistant Infection: A Threat to Our Economic Future","author":"World Bank Group","year":"2017"},{"issue":"5","key":"pone.0297921.ref007","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmi.2016.03.012","article-title":"Do we need new antibiotics?","volume":"22","author":"JM Rolain","year":"2016","journal-title":"Clinical Microbiology and Infection"},{"issue":"35","key":"pone.0297921.ref008","doi-asserted-by":"crossref","first-page":"E8109","DOI":"10.1073\/pnas.1809354115","article-title":"Benefits of antibiotics burden in low-income countries","volume":"115","author":"C Abat","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pone.0297921.ref009","first-page":"1538","article-title":"Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010\u20132011","author":"KE Fleming-Dutra"},{"issue":"5","key":"pone.0297921.ref010","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1016\/S2214-109X(21)00085-1","article-title":"Access to antibiotics: not a problem in some LMICs","volume":"9","author":"G Sulis","year":"2021","journal-title":"Lancet Glob Health"},{"issue":"3","key":"pone.0297921.ref011","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ijantimicag.2017.04.009","article-title":"Massive misuse of antibiotics by university students in all regions of China: implications for national policy","volume":"50","author":"X Wang","year":"2017","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"4","key":"pone.0297921.ref012","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.sjbs.2017.01.004","article-title":"Self-medication and antibiotic resistance: Crisis, current challenges, and prevention","volume":"24","author":"IA Rather","year":"2017","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"pone.0297921.ref013","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4103\/jgid.jgid_110_18","article-title":"Global Contributors to Antibiotic Resistance","volume":"11","author":"A Chokshi","year":"2019","journal-title":"J Glob Infect Dis"},{"issue":"5","key":"pone.0297921.ref014","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jcpt.12730","article-title":"The knowledge, attitude, and practice of health practitioners towards antibiotic prescribing and resistance in developing countries systematic review","volume":"43","author":"PS Chaw","year":"2018","journal-title":"J Clin Pharm Ther"},{"key":"pone.0297921.ref015","first-page":"1537","article-title":"The future of antibiotics and resistance: a tribute to a career of leadership by John Bartlett","author":"B Spellberg"},{"issue":"3","key":"pone.0297921.ref016","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"J Davies","year":"2010","journal-title":"Microbiol Mol Biol Rev"},{"key":"pone.0297921.ref017","unstructured":"World Health Organization (WHO). Critically important antimicrobials for human medicine: 6th revision. 2019."},{"issue":"8","key":"pone.0297921.ref018","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/cid\/ciw475","article-title":"World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies to Control Antimicrobial Resistance From Food Animal Production","volume":"63","author":"for the World Health Organization Advisory Group BMoISoAR","year":"2016","journal-title":"Clinical Infectious Diseases"},{"key":"pone.0297921.ref019","unstructured":"World Health Organization (WHO). WHO Access, Watch, Reserve (AWaRe) classification of antibiotics for evaluation and monitoring of use, 2021. In: WHO-HMP-HPS-EML-2021.04-eng, editor. 2021."},{"key":"pone.0297921.ref020","unstructured":"World Health Organization (WHO). Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2022. 2022."},{"issue":"1","key":"pone.0297921.ref021","article-title":"Carbapenem Resistance: A Review","volume":"6","author":"FS Codjoe","year":"2017","journal-title":"Med Sci (Basel)"},{"issue":"1","key":"pone.0297921.ref022","first-page":"15","article-title":"Carbapenem resistance: an overview of the problem and future perspectives","volume":"3","author":"G. Meletis","year":"2016","journal-title":"Ther Adv Infect Dis"},{"key":"pone.0297921.ref023","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jgar.2020.10.009","article-title":"Antibiotic resistance surveillance systems: A review","volume":"23","author":"OO Diallo","year":"2020","journal-title":"Journal of Global Antimicrobial Resistance"},{"issue":"3","key":"pone.0297921.ref024","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/S1473-3099(17)30485-1","article-title":"Surveillance for control of antimicrobial resistance","volume":"18","author":"E Tacconelli","year":"2018","journal-title":"The Lancet Infectious Diseases"},{"key":"pone.0297921.ref025","unstructured":"World Health Organization (WHO). Global Action Plan on Antimicrobial Resistance. 2015."},{"key":"pone.0297921.ref026","unstructured":"European Centre for Diseases Control and Prevention (European CDC). Antimicrobial consumption in the EU\/EEA (ESAC-Net) Annual Epidemiological Report for 2021. 2021."},{"key":"pone.0297921.ref027","unstructured":"World Health Organization (WHO). ANTIMICROBIAL RESISTANCE: Global Report on Surveillance. 2014."},{"key":"pone.0297921.ref028","unstructured":"World Health Organization (WHO). Global Antimicrobial Resistance Surveillance System (GLASS) Report Early implementation 2017\u201318. 2018."},{"key":"pone.0297921.ref029","unstructured":"World Health Organization (WHO). WHO Report on Surveillance of Antibiotic Consumption: 2016\u20132018 Early Implementation. Report. 2018."},{"key":"pone.0297921.ref030","first-page":"1668789","article-title":"Klebsiella pneumonia and Its Antibiotic Resistance: A Bibliometric Analysis","volume":"2022","author":"Y Li","year":"2022","journal-title":"Biomed Res Int"},{"issue":"3","key":"pone.0297921.ref031","doi-asserted-by":"crossref","first-page":"743","DOI":"10.14202\/vetworld.2022.743-749","article-title":"Antimicrobial resistance: One Health approach","volume":"15","author":"ME Velazquez-Meza","year":"2022","journal-title":"Vet World"},{"key":"pone.0297921.ref032","first-page":"0149","article-title":"Injudicious antibiotic use: an unforeseen consequence of the emphasis on patient satisfaction?","author":"E. Shapiro"},{"key":"pone.0297921.ref033","first-page":"1478","article-title":"Antibiotic overuse: a key driver of antimicrobial resistance","author":"LJ Shallcross"},{"issue":"8","key":"pone.0297921.ref034","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1699-0463.1998.tb00222.x","article-title":"Resistance to antimicrobial agents used for animal therapy in pathogenic-, zoonotic- and indicator bacteria isolated from different food animals in Denmark: a baseline study for the Danish Integrated Antimicrobial Resistance Monitoring Programme (DANMAP)","volume":"106","author":"FM Aarestrup","year":"1998","journal-title":"Apmis"},{"issue":"2","key":"pone.0297921.ref035","first-page":"181","article-title":"Comparison of antimicrobial resistance in generic Escherichia coil and Salmonella spp. cultured from identical fecal samples in finishing swine","volume":"72","author":"C Varga","year":"2008","journal-title":"Can J Vet Res"},{"issue":"9","key":"pone.0297921.ref036","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S1473-3099(11)70054-8","article-title":"Non-prescription antimicrobial use worldwide: a systematic review","volume":"11","author":"DJ Morgan","year":"2011","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"pone.0297921.ref037","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/jac\/dkt443","article-title":"Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries","volume":"69","author":"I Chantziaras","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"10014","key":"pone.0297921.ref038","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(15)00473-0","article-title":"Understanding the mechanisms and drivers of antimicrobial resistance","volume":"387","author":"AH Holmes","year":"2016","journal-title":"Lancet"},{"issue":"Suppl 3","key":"pone.0297921.ref039","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1469-0691.2009.02725.x","article-title":"Antibiotic consumption and link to resistance","volume":"15","author":"H. Goossens","year":"2009","journal-title":"Clin Microbiol Infect"},{"issue":"18","key":"pone.0297921.ref040","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals","volume":"112","author":"TP Van Boeckel","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"pone.0297921.ref041","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1473-3099(05)70189-4","article-title":"Antimicrobial resistance in developing countries. Part I: recent trends and current status","volume":"5","author":"IN Okeke","year":"2005","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"pone.0297921.ref042","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jinf.2016.11.001","article-title":"Attributable mortality of ICU-acquired bloodstream infections: Impact of the source, causative micro-organism, resistance profile, and antimicrobial therapy","volume":"74","author":"C Adrie","year":"2017","journal-title":"Journal of Infection"},{"issue":"5","key":"pone.0297921.ref043","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"J Cohen","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pone.0297921.ref044","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1503\/cmaj.160798","article-title":"Reducing the global burden of sepsis","volume":"189","author":"S Dugani","year":"2017","journal-title":"Cmaj"},{"key":"pone.0297921.ref045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.12688\/f1000research.18302.1","article-title":"Reinventing the antimicrobial pipeline in response to the global crisis of antimicrobial-resistant infections","volume":"8","author":"AC Singer","year":"2019","journal-title":"F1000Res"},{"issue":"4","key":"pone.0297921.ref046","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"CL Ventola","year":"2015","journal-title":"P t"},{"issue":"4","key":"pone.0297921.ref047","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/antibiotics4040467","article-title":"Antibiotic Stewardship Initiatives as Part of the UK 5-Year Antimicrobial Resistance Strategy","volume":"4","author":"AP Johnson","year":"2015","journal-title":"Antibiotics (Basel)"},{"issue":"4","key":"pone.0297921.ref048","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jhin.2019.02.019","article-title":"Tackling antimicrobial resistance 2019\u20132024\u2013the UK\u2019s five-year national action plan","volume":"101","author":"M Courtenay","year":"2019","journal-title":"The Journal of Hospital Infection"},{"issue":"Suppl 1","key":"pone.0297921.ref049","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40121-015-0080-z","article-title":"Antimicrobial Stewardship from Policy to Practice: Experiences from UK Antimicrobial Pharmacists","volume":"4","author":"M Gilchrist","year":"2015","journal-title":"Infect Dis Ther"},{"key":"pone.0297921.ref050","unstructured":"Government Offices of Sweden. Swedish Strategy to Combat Antibiotic Resistance. 2020."},{"issue":"5","key":"pone.0297921.ref051","article-title":"Exploring the One Health Perspective in Sweden\u2019s Policies for Containing Antibiotic Resistance","volume":"10","author":"J Eriksen","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"pone.0297921.ref052","doi-asserted-by":"crossref","first-page":"53","DOI":"10.17645\/pag.v8i4.3356","article-title":"Adapting to a Global Health Challenge: Managing Antimicrobial Resistance in the Nordics","volume":"8","author":"M Time","year":"2020","journal-title":"Politics and Governance"},{"key":"pone.0297921.ref053","unstructured":"The Federal Government of Germany. DART 2020: Fourth interim report. 2019."},{"key":"pone.0297921.ref054","unstructured":"CDC) ECfDCaPE. Surveillance of antimicrobial resistance in Europe\u2013annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2017. European Centre for Disease Prevention and Control Solna, Sweden; 2018."},{"key":"pone.0297921.ref055","unstructured":"European Centre for Diseases Control and Prevention (European CDC). Antimicrobial Resistance Surveillance in Europe. 2022."},{"key":"pone.0297921.ref056","unstructured":"The World Bank. Brunei Darussalam. In: The World Bank, editor. 2023."},{"key":"pone.0297921.ref057","unstructured":"Ministry of Health (MoH) and Ministry of Primary Resources and Tourism (MPRT) BD. Brunei Darussalam Antimicrobial Resistance National Action Plan, 2019\u20132023."},{"key":"pone.0297921.ref058","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijregi.2021.09.009","article-title":"Trends in antimicrobial consumption in Bhutan","volume":"1","author":"T Tshering","year":"2021","journal-title":"IJID Reg"},{"key":"pone.0297921.ref059","unstructured":"World Health Organization (WHO). 2021 TrACSS Country Report on the Implementation of National Action Plan on Antimicrobial Resistance (AMR), Bhutan. 2021."},{"key":"pone.0297921.ref060","unstructured":"World Health Organization (WHO). 2021 TrACSS Country Report on the Implementation of National Action Plan on Antimicrobial Resistance (AMR), Peru. 2021."},{"issue":"12","key":"pone.0297921.ref061","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1089\/fpd.2011.0950","article-title":"Association Between Antimicrobial Resistance in Escherichia coli Isolates from Food Animals and Blood Stream Isolates from Humans in Europe: An Ecological Study","volume":"8","year":"2011","journal-title":"Foodborne Pathogens and Disease"},{"issue":"3","key":"pone.0297921.ref062","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cid\/ciu785","article-title":"Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review","volume":"60","author":"B Lazarus","year":"2014","journal-title":"Clinical Infectious Diseases"},{"key":"pone.0297921.ref063","unstructured":"World Health Organization (WHO). 2021 TrACSS Country Report on the Implementation of National Action Plan on Antimicrobial Resistance (AMR), Cote d\u2019Ivoire. 2021."},{"key":"pone.0297921.ref064","first-page":"2542","article-title":"Global antibiotic consumption and usage in humans, 2000\u201318: a spatial modeling study","author":"AJ Browne"},{"issue":"5","key":"pone.0297921.ref065","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.1016\/S2214-109X(21)00024-3","article-title":"Community-based antibiotic access and use in six low-income and middle-income countries: a mixed-method approach","volume":"9","author":"NTT Do","year":"2021","journal-title":"Lancet Glob Health"},{"issue":"6","key":"pone.0297921.ref066","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ijantimicag.2018.09.022","article-title":"Non-prescription sales of antimicrobial agents at community pharmacies in developing countries: a systematic review","volume":"52","author":"MHF Sakeena","year":"2018","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"12","key":"pone.0297921.ref067","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S1473-3099(19)30324-X","article-title":"Assessment of non-prescription antibiotic dispensing at community pharmacies in China with simulated clients: a mixed cross-sectional and longitudinal study","volume":"19","author":"J Chang","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"pone.0297921.ref068","article-title":"Antibiotic Dispensation without a Prescription Worldwide: A Systematic Review","volume":"9","author":"Batista AD","year":"2020","journal-title":"Antibiotics (Basel)"},{"issue":"6","key":"pone.0297921.ref069","first-page":"333","article-title":"Self-medication with antibiotics obtained from private pharmacies in Abidjan, Ivory Coast","volume":"40","author":"A Hounsa","year":"2010","journal-title":"Med Mal Infect"},{"key":"pone.0297921.ref070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijid.2017.01.014","article-title":"Self-medication and self-prescription with antibiotics in the Middle East- do they really happen? A systematic review of the prevalence, possible reasons, and outcomes","volume":"57","author":"F Alhomoud","year":"2017","journal-title":"Int J Infect Dis"},{"issue":"6","key":"pone.0297921.ref071","doi-asserted-by":"crossref","first-page":"e002104","DOI":"10.1136\/bmjgh-2019-002104","article-title":"Tackling antimicrobial resistance in low-income and middle-income countries","volume":"4","author":"S Pokharel","year":"2019","journal-title":"BMJ Glob Health"},{"issue":"7","key":"pone.0297921.ref072","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1473-3099(16)30078-0","article-title":"Global leadership against antimicrobial resistance ought to include developing countries","volume":"16","author":"S Raut","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"pone.0297921.ref073","doi-asserted-by":"crossref","first-page":"e000518","DOI":"10.1136\/bmjgh-2017-000518","article-title":"Antimicrobial resistance and universal health coverage","volume":"2","author":"G Bloom","year":"2017","journal-title":"BMJ Glob Health"},{"key":"pone.0297921.ref074","author":"World Health Organization (WHO)","year":"2019","journal-title":"ANTIMICROBIAL STEWARDSHIP PROGRAMMES IN HEALTH-CARE FACILITIES IN LOW AND MIDDLE-INCOME COUNTRIES: A WHO PRACTICAL TOOL KIT"},{"issue":"11","key":"pone.0297921.ref075","article-title":"Antibiotic Use and Antibiotic Resistance: Public Awareness Survey in the Republic of Cyprus","volume":"9","author":"M Michaelidou","year":"2020","journal-title":"Antibiotics (Basel)"},{"issue":"46","key":"pone.0297921.ref076","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.46.1800516","article-title":"Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017","volume":"23","author":"C Suetens","year":"2018","journal-title":"Euro Surveill"},{"issue":"8","key":"pone.0297921.ref077","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.3390\/ijerph8083246","article-title":"Descriptive study on parents\u2019 knowledge, attitudes and practices on antibiotic use and misuse in children with upper respiratory tract infections in Cyprus","volume":"8","author":"A Rousounidis","year":"2011","journal-title":"Int J Environ Res Public Health"},{"key":"pone.0297921.ref078","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5152\/cjms.2019.697","article-title":"Implementations Related to the Use of Antibiotics and Data Sources Used by Community Pharmacists in the Northern Cyprus","volume":"4","author":"K S\u00fcer","year":"2019","journal-title":"Cyprus Journal of Medical Sciences"},{"key":"pone.0297921.ref079","unstructured":"World Health Organization (WHO). Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report. 2021."},{"issue":"11","key":"pone.0297921.ref080","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8112004","article-title":"High Prevalence of Antibiotic Resistance in Iranian Helicobacter pylori Isolates: Importance of Functional and Mutational Analysis of Resistance Genes and Virulence Genotyping","volume":"8","author":"N Farzi","year":"2019","journal-title":"J Clin Med"},{"issue":"4","key":"pone.0297921.ref081","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/jgid.jgid_113_17","article-title":"Multidrug-Resistant Pseudomonas aeruginosa in Iran: A Systematic Review and Metaanalysis","volume":"10","author":"H Vaez","year":"2018","journal-title":"J Glob Infect Dis"},{"issue":"9","key":"pone.0297921.ref082","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jiac.2020.04.022","article-title":"High rate of resistance to ceftriaxone and azithromycin among Shigella spp. isolates at three children\u2019s referral hospitals in Northeast Iran","volume":"26","author":"K Salimiyan rizi","year":"2020","journal-title":"Journal of Infection and Chemotherapy"},{"issue":"1","key":"pone.0297921.ref083","first-page":"e129629","article-title":"Prevalence and Antimicrobial Resistance Patterns in ESKAPE Pathogens in Iran","volume":"11","author":"L Azimi","year":"2023","journal-title":"Arch Pediatr Infect Dis"},{"key":"pone.0297921.ref084","first-page":"47","article-title":"Rational Drug Use in Iran: A Call for Action","author":"S Mousavi","year":"2014","journal-title":"Journal of Pharmaceutical Care"},{"issue":"2","key":"pone.0297921.ref085","first-page":"35","article-title":"Rational prescription of drug in Iran: statistics and trends for policymakers","volume":"5","author":"P Bastani","year":"2018","journal-title":"Health Management & Information Science"},{"key":"pone.0297921.ref086","first-page":"384","article-title":"Irrational antibiotic prescribing: a local issue or global concern?","volume":"12","author":"S Hashemi","year":"2013","journal-title":"EXCLI journal"},{"issue":"1","key":"pone.0297921.ref087","first-page":"48","article-title":"Antibiotics self-medication among Southern Iranian university students","volume":"6","author":"S Sarahroodi","year":"2010","journal-title":"IJP-International Journal of Pharmacology"},{"issue":"1876","key":"pone.0297921.ref088","article-title":"Human, animal and environmental contributors to antibiotic resistance in low-resource settings: integrating behavioural, epidemiological and One Health approaches","volume":"285","author":"EK Rousham","year":"2018","journal-title":"Proc Biol Sci"},{"issue":"6","key":"pone.0297921.ref089","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/cid\/cix879","article-title":"Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income Countries","volume":"66","author":"M Nadimpalli","year":"2018","journal-title":"Clin Infect Dis"},{"key":"pone.0297921.ref090","article-title":"Awareness of Antibiotic Use and Resistance in Jordanian Community","volume":"11","author":"DH Abdel-Qader","year":"2020","journal-title":"J Prim Care Community Health"},{"key":"pone.0297921.ref091","article-title":"Supply chain factors and antimicrobial stewardship","author":"Nduta Kamere","year":"2023","journal-title":"Bulletin of the World Health Organization"},{"issue":"7","key":"pone.0297921.ref092","article-title":"Drivers of Antibiotic Resistance Transmission in Low- and Middle-Income Countriesfrom a \"One Health\" Perspective-A Review","volume":"9","author":"K Iskandar","year":"2020","journal-title":"Antibiotics (Basel)"},{"issue":"6","key":"pone.0297921.ref093","first-page":"1207","article-title":"The Beta-Lactam Antibiotics as an Empirical Therapy in a Developing Country: An Update on Their Current Status and Recommendations to Counter the Resistance against Them","volume":"7","author":"B Thakuria","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"pone.0297921.ref094","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/B978-0-12-813280-7.00036-0","volume-title":"Enzymes in Food Biotechnology","author":"R Rodriguez-Herrera","year":"2019"},{"issue":"4","key":"pone.0297921.ref095","first-page":"e2428","article-title":"Self-medication with Antibiotics in WHO Southeast Asian Region: A Systematic Review","volume":"10","author":"G Nepal","year":"2018","journal-title":"Cureus"},{"issue":"10","key":"pone.0297921.ref096","first-page":"e567","article-title":"Antibiotic use for viral acute respiratory tract infections remains common","volume":"21","author":"MH Ebell","year":"2015","journal-title":"Am J Manag Care"},{"issue":"1","key":"pone.0297921.ref097","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13756-018-0347-8","article-title":"Temporal relationship between antibiotic use and respiratory virus activities in the Republic of Korea: a time-series analysis","volume":"7","author":"S Ryu","year":"2018","journal-title":"Antimicrobial Resistance & Infection Control"},{"issue":"11","key":"pone.0297921.ref098","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cmi.2017.08.026","article-title":"What is antimicrobial stewardship?","volume":"23","author":"OJ Dyar","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"pone.0297921.ref099","unstructured":"The White House. National Action Plan For Combating Antibiotic-Resistant Bacteria. Washington United States: 2015."},{"issue":"7","key":"pone.0297921.ref100","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/sur.2020.145","article-title":"Increasing Globalization and the Movement of Antimicrobial Resistance between Countries","volume":"21","year":"2020","journal-title":"Surgical Infections"},{"issue":"8","key":"pone.0297921.ref101","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/taz036","article-title":"Global geographic trends in antimicrobial resistance: the role of international travel","volume":"26","author":"I Frost","year":"2019","journal-title":"J Travel Med"},{"issue":"5","key":"pone.0297921.ref102","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/QCO.0000000000000751","article-title":"Antimicrobial-resistant bacteria in international travelers","volume":"34","author":"S Sridhar","year":"2021","journal-title":"Curr Opin Infect Dis"},{"issue":"6","key":"pone.0297921.ref103","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/cid\/ciu957","article-title":"Antimicrobials increase travelers\u2019 risk of colonization by extended-spectrum beta-lactamase-producing Enterobacteriaceae","volume":"60","author":"A Kantele","year":"2015","journal-title":"Clin Infect Dis"},{"key":"pone.0297921.ref104","doi-asserted-by":"crossref","first-page":"101548","DOI":"10.1016\/j.tmaid.2019.101548","article-title":"Infectious disease symptoms and microbial carriage among French medical students travelling abroad: A prospective study","volume":"34","author":"TL Dao","year":"2020","journal-title":"Travel Med Infect Dis"},{"key":"pone.0297921.ref105","unstructured":"World Health Organization (WHO). WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR): report of the 7th meeting, 17\u201320 October 2016, Raleigh, United States of America. Geneva: World Health Organization, 2018 2018. Report No.: Contract No.: WHO\/NMH\/FOS\/FZD18.1."},{"key":"pone.0297921.ref106","doi-asserted-by":"crossref","first-page":"100563","DOI":"10.1016\/j.lanepe.2022.100563","article-title":"EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach","volume":"26","author":"N Babu Rajendran","year":"2023","journal-title":"Lancet Reg Health Eur"},{"key":"pone.0297921.ref107","first-page":"1474","article-title":"Quantifying drivers of antibiotic resistance in humans: a systematic review","author":"A Chatterjee"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0297921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T13:33:00Z","timestamp":1707139980000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0297921"}},"subtitle":[],"editor":[{"given":"Balew","family":"Arega Negatie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":107,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0297921","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]}}}