{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:19:55Z","timestamp":1747196395554,"version":"3.40.5"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>This study evaluated the long-term effects of percutaneous intervention in children and adolescents with transplant renal artery stenosis (TRAS).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Twenty patients had significant stenosis (&gt;50%) and underwent percutaneous transluminal angioplasty (PTA\/stenting) (TRAS group-intervention); 14 TNS (non-significant group -control) patients did not have significant stenosis (\u226450%) and were treated clinically. The combined primary endpoints were death from all causes and late graft failure. The secondary endpoints were serum creatinine (SCr), systolic blood pressure (SBP), and diastolic blood pressure (DBP).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>No statistically significant difference was found between TRAS\u2014Intervention(N = 20) and TNS groups\u2014Control (N = 14) for these clinical parameters: deaths, 1 (5.0%) vs. 0 (0.0%) (p = 1.000) and graft loss, 4 (20.0%) vs. 2 (14.3%) (p = 1.000). For the secondary endpoints, after 1 month and 1 year the values of SCr, SBP, and DBP were similar between the two groups but not statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>In the TRAS group (intervention), the stent implantation was beneficial for treating refractory hypertension and reducing blood pressure (BP) in children and adolescents. Despite the outcomes being similar in the two groups, it can be inferred that the patients in the TRAS group (intervention) would have had a worse outcome without the percutaneous intervention.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>TRAS treatment with stenting can be considered for children and adolescents. Because the sample in the present study comprised of only a specific population, further studies are needed for generalization.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>The trial was registered at clinictrials.gov with trial registration number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04225338\" xlink:type=\"simple\">NCT04225338<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0297975","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T17:31:14Z","timestamp":1711733474000},"page":"e0297975","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective analysis of percutaneous intervention of the renal artery in transplanted kidneys in children and adolescents at a tertiary public hospital"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-770X","authenticated-orcid":true,"given":"Ana Carolina Buso","family":"Faccinetto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Rocha Feitosa","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Cristina","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Campos","family":"Orellana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Att\u00edlio","family":"Galhardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Kanhouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoela Linhares Machado","family":"Barteczko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio","family":"Tedesco J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie Jeanne Magioli","family":"Bravo-Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir Ambr\u00f3sio","family":"Moises","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0750-7360","authenticated-orcid":true,"given":"Jos\u00e9 Osmar Medina","family":"Pestana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia Maria Camelo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Henrique Pereira","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"pone.0297975.ref001","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s00467-004-1656-0","article-title":"Percutaneous treatment of transplant renal artery stenosis in children","volume":"19","author":"HARL Repetto","year":"2004","journal-title":"Pediatr Nephrol"},{"key":"pone.0297975.ref002","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1590\/s1677-5538.ibju.2018.0737","article-title":"Outcomes of endovascular treatment of renal arterial stenosis in transplanted kidneys","volume":"45","author":"AS Bull","year":"2019","journal-title":"Int Braz J Urol"},{"key":"pone.0297975.ref003","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00467-013-2681-7","article-title":"Transplant renal artery stenosis in children: risk factors and outcome after endovascular treatment","volume":"29","author":"G Ghirardo","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"pone.0297975.ref004","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1159\/000242431","article-title":"Incidence, predictors and outcomes of transplant renal artery stenosis after kidney transplantation: analysis of USRDS","volume":"30","author":"FP Hurst","year":"2009","journal-title":"Am J Nephrol"},{"key":"pone.0297975.ref005","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2215\/CJN.02960313","article-title":"Renal relevant radiology: imaging in kidney transplantation","volume":"9","author":"A. 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