{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:57:55Z","timestamp":1788886675096,"version":"build-2803163510"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409707\/2016-3"],"award-info":[{"award-number":["409707\/2016-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>In peripheral artery disease (PAD) patients, the joint profile of low strength and cardiorespiratory fitness on movement behaviors, specifically physical activity levels and sedentary time, remains unclear.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To investigate the joint profiles between cardiorespiratory and neuromuscular fitness and daily physical activity among PAD patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Cross-sectional study in a sample of 155 PAD patients. We measured their physical activity level per week using accelerometers, assessed their muscle strength through a sit-to-stand test and cardiorespiratory fitness through a six-minute walk test. Patients were categorized into three groups: those with high strength and cardiorespiratory fitness (NC, n = 28), those with at least one component classified as low (1C, n = 88), and those with both components classified as low fitness (2C, n = 39).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>The patients in the 1C and 2C groups spent less time engaged in low-light and moderate activities compared to the NC group (low-light: NC: 2291 \u00b1 680 minutes\/week vs. 1C: 1826 \u00b1 649 minutes\/week vs. 2C: 1885 \u00b1 651 minutes\/week, p = .005; moderate: NC: 2617 \u00b1 796 minutes\/week vs. 1C: 2071 \u00b1 767 minutes\/week vs. 2C: 2092 \u00b1 776 minutes\/week, p = .005) and the patients in the 2C group spent less time engaged in vigorous activities compared to the NC and 1C groups (NC: 155 \u00b1 148 minutes\/week vs. 1C: 110 \u00b1 110 minutes\/week vs. 2C: 64 \u00b1 70 minutes\/week, p = .003).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>PAD patients with low strength and\/or cardiorespiratory fitness are more likely to spend less time engaging in low-light and moderate physical activities and patients with low fitness in both components are more likely to spend less time engaging in vigorous physical activity.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0298289","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T17:41:09Z","timestamp":1711561269000},"page":"e0298289","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["The joint profiles of cardiorespiratory fitness and muscle strength on daily physical activity levels in patients with symptomatic peripheral artery disease: A cross-sectional study"],"prefix":"10.1371","volume":"19","author":[{"given":"Paulo","family":"Longano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2807-7109","authenticated-orcid":true,"given":"Eduardo Caldas","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan Massena","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno Quintella","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-8852","authenticated-orcid":true,"given":"Gabriel Grizzo","family":"Cucato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-3433","authenticated-orcid":true,"given":"Marilia Almeida","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-6504","authenticated-orcid":true,"given":"H\u00e9lcio","family":"Kanegusuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Mendes","family":"Ritti-Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"issue":"4","key":"pone.0298289.ref001","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1532-5415.2008.01633.x","article-title":"Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial disease","volume":"56","author":"MM McDermott","year":"2008","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"pone.0298289.ref002","first-page":"410","article-title":"physical activity levels in peripheral artery disease patients","volume":"113","author":"AM Gerage","year":"2019","journal-title":"Arq Bras Cardiol"},{"key":"pone.0298289.ref003","article-title":"European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication","author":"J Nordanstig","year":"2023","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"11","key":"pone.0298289.ref004","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/ATVBAHA.120.313831","article-title":"Skeletal muscle pathology in peripheral artery disease: a brief review","volume":"40","author":"MM McDermott","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"pone.0298289.ref005","first-page":"597","article-title":"Study and evaluation of patients with obliterating arteriopathy of the lower limbs: use of isokinetics to analyze muscular strength and fatigue","volume":"47","author":"B Demonty","year":"2004","journal-title":"Ann Readapt Med Phys"},{"issue":"1","key":"pone.0298289.ref006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2340\/16501977198618915","article-title":"Isokinetic strength and endurance in peripheral arterial insufficiency with intermittent claudication","volume":"18","author":"B Gerdle","year":"1986","journal-title":"Scand J Rehabil Med"},{"issue":"4","key":"pone.0298289.ref007","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1161\/01.CIR.90.4.1866","article-title":"Superiority of treadmill walking exercise versus strength training for patients with peripheral arterial disease. Implications for the mechanism of the training response","volume":"90","author":"WR Hiatt","year":"1994","journal-title":"Circulation"},{"issue":"3","key":"pone.0298289.ref008","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1249\/MSS.0000000000000434","article-title":"Clinical predictors of ventilatory threshold achievement in patients with claudication","volume":"47","author":"BQ Farah","year":"2015","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"pone.0298289.ref009","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jvs.2012.07.051","article-title":"Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease","volume":"57","author":"NJ Leeper","year":"2013","journal-title":"J Vasc Surg"},{"issue":"1","key":"pone.0298289.ref010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/oby.21264","article-title":"Which is more important for reducing the odds of metabolic syndrome in men: Cardiorespiratory or muscular fitness?","volume":"24","author":"M Misigoj-Durakovic","year":"2016","journal-title":"Obesity"},{"issue":"4","key":"pone.0298289.ref011","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11886-013-0347-5","article-title":"Functional impairment in peripheral artery disease and how to improve it in 2013","volume":"15","author":"MM McDermott","year":"2013","journal-title":"Curr Cardiol Rep"},{"issue":"6","key":"pone.0298289.ref012","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.jvs.2007.07.038","article-title":"Patterns of ambulatory activity in subjects with and without intermittent claudication","volume":"46","author":"AW Gardner","year":"2007","journal-title":"J Vasc Surg"},{"issue":"1","key":"pone.0298289.ref013","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12529-014-9408-4","article-title":"Barriers to physical activity in patients with intermittent claudication","volume":"22","author":"JP Barbosa","year":"2015","journal-title":"Int J Behav Med"},{"issue":"3","key":"pone.0298289.ref014","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jvn.2021.07.001","article-title":"Effect of frailty on physical activity levels and walking capacity in patients with peripheral artery disease: A cross-sectional study","volume":"39","author":"BQ Farah","year":"2021","journal-title":"J Vasc Nurs"},{"issue":"2","key":"pone.0298289.ref015","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jvn.2020.02.004","article-title":"Impact of obesity on walking capacity and cardiovascular parameters in patients with peripheral artery disease: A cross-sectional study","volume":"38","author":"H Kanegusuku","year":"2020","journal-title":"J Vasc Nurs"},{"issue":"9","key":"pone.0298289.ref016","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease","volume":"116","author":"MH Criqui","year":"2015","journal-title":"Circ Res"},{"issue":"1","key":"pone.0298289.ref017","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1123\/japa.17.1.17","article-title":"Accelerometer assessment of physical activity in active, healthy older adults","volume":"17","author":"JL Copeland","year":"2009","journal-title":"J Aging Phys Act"},{"issue":"6","key":"pone.0298289.ref018","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2459\/JCM.0000000000001472","article-title":"Is the Walking Impairment Questionnaire a surrogate marker of 6-minute walking test performance in patients with peripheral artery disease with different degrees of claudication symptoms?","volume":"24","author":"PM Cunha","year":"2023","journal-title":"J Cardiovasc Med"},{"key":"pone.0298289.ref019","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.avsg.2020.07.047","article-title":"Expanding the Use of Six-Minute Walking Test in Patients with Intermittent Claudication","volume":"70","author":"RM Ritti-Dias","year":"2021","journal-title":"Ann Vasc Surg"},{"issue":"6","key":"pone.0298289.ref020","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1532-5415.1998.tb03804.x","article-title":"The clinical utility of a six-minute walk test in peripheral arterial occlusive disease patients","volume":"46","author":"PS Montgomery","year":"1998","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"pone.0298289.ref021","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1590\/S1413-35552012005000122","article-title":"Reference equations for the six-minute walk distance based on a Brazilian multicenter study","volume":"17","author":"RR Britto","year":"2013","journal-title":"Braz J Phys Ther"},{"issue":"2","key":"pone.0298289.ref022","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"JM Guralnik","year":"1994","journal-title":"J Gerontol"},{"issue":"6","key":"pone.0298289.ref023","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jvs.2008.01.048","article-title":"The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication","volume":"47","author":"AW Gardner","year":"2008","journal-title":"J Vasc Surg"},{"issue":"6","key":"pone.0298289.ref024","first-page":"240","article-title":"Skeletal muscle and peripheral nerve changes caused by chronic arterial insufficiency\u2014significance and clinical correlations\u2014histological, histochemical and ultrastructural study","volume":"3","author":"AM Farinon","year":"1984","journal-title":"Clin Neuropathol"},{"issue":"2","key":"pone.0298289.ref025","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.CIR.87.2.413","article-title":"Chronic changes in skeletal muscle histology and function in peripheral arterial disease","volume":"87","author":"JG Regensteiner","year":"1993","journal-title":"Circulation"},{"issue":"5","key":"pone.0298289.ref026","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jvs.2005.01.037","article-title":"Skeletal muscle phenotype is associated with exercise tolerance in patients with peripheral arterial disease","volume":"41","author":"CD Askew","year":"2005","journal-title":"J Vasc Surg"},{"issue":"3","key":"pone.0298289.ref027","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jvs.2003.08.038","article-title":"Leg strength in peripheral arterial disease: associations with disease severity and lower-extremity performance","volume":"39","author":"MM McDermott","year":"2004","journal-title":"J Vasc Surg"},{"issue":"6","key":"pone.0298289.ref028","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.jvs.2011.12.010","article-title":"The Walking Impairment Questionnaire stair-climbing score predicts mortality in men and women with peripheral arterial disease","volume":"55","author":"A Jain","year":"2012","journal-title":"J Vasc Surg"},{"issue":"4","key":"pone.0298289.ref029","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jvs.2017.12.074","article-title":"Predictors of health-related quality of life in patients with symptomatic peripheral artery disease","volume":"68","author":"AW Gardner","year":"2018","journal-title":"J Vasc Surg"},{"issue":"4","key":"pone.0298289.ref030","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/1358863X18762599","article-title":"Minimal clinically important differences in treadmill, 6-minute walk, and patient-based outcomes following supervised and home-based exercise in peripheral artery disease","volume":"23","author":"AW Gardner","year":"2018","journal-title":"Vasc Med"},{"issue":"8","key":"pone.0298289.ref031","first-page":"452","article-title":"Resistance training as a treatment for older persons with peripheral artery disease: a systematic review and meta-analysis","volume":"54","author":"BJ Parmenter","year":"2020","journal-title":"Br J Sports Med"},{"issue":"4","key":"pone.0298289.ref032","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ejvs.2022.12.029","article-title":"Sit to Stand Muscle Power Is Related to Functional Performance at Baseline and After Supervised Exercise Training in Patients with Lower Extremity Peripheral Artery Disease","volume":"65","author":"S Lanzi","year":"2023","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"15","key":"pone.0298289.ref033","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jacc.2007.12.034","article-title":"Prognostic value of functional performance for mortality in patients with peripheral artery disease","volume":"51","author":"MM McDermott","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"pone.0298289.ref034","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1183\/09031936.00131612","article-title":"Simple functional performance tests and mortality in COPD","volume":"42","author":"MA Puhan","year":"2013","journal-title":"Eur Respir J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0298289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T17:41:42Z","timestamp":1711561302000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0298289"}},"subtitle":[],"editor":[{"given":"Hidetaka","family":"Hamasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0298289","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]}}}