{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:55:45Z","timestamp":1792590945924,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Adverse birth outcomes are the leading cause of neonatal mortality worldwide. Ethiopia is one of the countries struggling to reduce neonatal mortality through different strategies, but neonatal mortality remains high for many reasons. Despite adverse birth outcomes being a public health problem in Ethiopia, the contribution of Premature rupture of the membrane to the adverse fetal birth outcome is neglected and not well explained in our country. This study aims to assess fetal birth outcomes and associated factors among mothers with all types of PROM at Specialized Hospitals in Amhara Region, Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A facility-based cross-sectional study design was applied among 538 mothers with premature rapture of the membrane at Amhara region specialized hospitals. A simple random sampling technique was employed to select the medical charts diagnosed with all types of PROM and giving birth in the hospital within the period from July 8, 2019, to July 7, 2021. The data was collected using a checklist, entered into EPI Data version 3.1, and analyzed using SPSS version 23. A binary logistic regression model was used to see the association between independent and dependent variables. A P-value &lt;0.05 was used to declare the statistical significance. The AOR with 95% CI was used to measure the strength of the association.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>Adverse birth outcome among all types of Premature rupture of membrane mothers was 33.1% [95% CI 29.2\u201337.2]. Rural residents [AOR = 2.94, 95% CI:1.73\u20134.97], have a history of urinary tract infection [AOR = 6.87, 95% CI: 2.77\u201317.01], anemia [AOR = 7.51, 95% CI: 2.88\u201319.62], previous history of adverse birth outcome [AOR = 3.54, 95% CI: 1.32\u20139.47] and less than two years interpregnancy interval [AOR = 6.07, 95% CI: 2.49\u201314.77] were positively associated with adverse birth outcome compared to their counterparts.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The adverse birth outcome was high in the Amhara region as compared to the World Health Organization\u2019s estimated figure and target; the target is less than 15%. History of the previous adverse birth outcome, residence, urinary tract infection, Anemia, and interpregnancy interval had an association with adverse birth outcomes. Therefore, strengthening close follow-up for mothers who had previous adverse birth outcomes, screening and treatment of urinary tract infection, anemia prevention, and maximizing birth interval are recommended for reducing adverse birth outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0298319","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T17:36:11Z","timestamp":1711992971000},"page":"e0298319","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adverse fetal birth outcomes and its associated factors among mothers with premature rupture of membrane in Amhara region, Ethiopia"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1062-0365","authenticated-orcid":true,"given":"Abebe Abrha","family":"Alene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endalkachew Worku","family":"Mengesha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizachew Worku","family":"Dagnew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"issue":"1","key":"pone.0298319.ref001","first-page":"178","article-title":"Preterm premature rupture of the membranes.","volume":"101","author":"BM Mercer","year":"2003","journal-title":"Obstetrics & Gynecology."},{"issue":"1","key":"pone.0298319.ref002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.12691\/ajcmr-2-1-4","article-title":"The incidence and management outcome of preterm premature rupture of membranes (PPROM) in a tertiary hospital in Nigeria.","volume":"2","author":"O TC","year":"2014","journal-title":"American Journal of Clinical Medicine Research"},{"issue":"09","key":"pone.0298319.ref003","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4236\/ojog.2015.59072","article-title":"Premature rupture of membranes characteristics, determinants, and outcomes of in Benghazi, Libya.","volume":"5","author":"MM Gahwagi","year":"2015","journal-title":"Open Journal of Obstetrics and Gynecology"},{"key":"pone.0298319.ref004","first-page":"2020","article-title":"Predictors of premature rupture of membranes among pregnant women in rural Uganda: a cross-sectional study at a tertiary teaching hospital","author":"S Byonanuwe","year":"2020","journal-title":"International journal of reproductive medicine"},{"key":"pone.0298319.ref005","first-page":"2020","article-title":"Prevalence of preterm premature rupture of membrane and its associated factors among pregnant women admitted in Debre Tabor General Hospital, North West Ethiopia: institutional-based cross-sectional study.","author":"D Addisu","year":"2020","journal-title":"Obstetrics and Gynecology International."},{"issue":"2","key":"pone.0298319.ref006","doi-asserted-by":"crossref","first-page":"99","DOI":"10.21608\/ejcm.2018.11055","article-title":"Prevalence and outcome of preterm premature rupture of membranes (PPROM) among pregnant women attending Ain Shams maternity hospital.","volume":"36","author":"HA Abouseif","year":"2018","journal-title":"Egyptian Journal of Community Medicine"},{"issue":"1","key":"pone.0298319.ref007","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005302.pub3","article-title":"Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more).","author":"P Middleton","year":"2017","journal-title":"Cochrane database of systematic reviews."},{"issue":"5","key":"pone.0298319.ref008","first-page":"423","article-title":"Gender trouble: The World Health Organization, the International Statistical Classification of Diseases and Related Health Problems (ICD)-11 and the trans kids","volume":"14","author":"S. Winter","year":"2017","journal-title":"Sexual"},{"key":"pone.0298319.ref009","volume-title":"Global nutrition targets 2025: low birth weight policy brief","author":"World Health Organization","year":"2014"},{"issue":"49","key":"pone.0298319.ref010","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1016\/j.vaccine.2016.03.047","article-title":"Congenital anomalies: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data","volume":"34","author":"M DeSilva","year":"2016","journal-title":"Vaccine"},{"key":"pone.0298319.ref011","first-page":"2021","article-title":"Congenital Anomalies and Associated Factors among Newborns in Bishoftu General Hospital, Oromia, Ethiopia: A Retrospective Study","author":"S Gedamu","year":"2021","journal-title":"Journal of Environmental and Public Health"},{"issue":"317","key":"pone.0298319.ref012","first-page":"2","article-title":"Factors associated with preterm birth among mothers who gave birth in Dodola town hospitals, Southeast Ethiopia: institutional based cross-sectional study.","volume":"16","author":"D Woldeyohannes","year":"2019","journal-title":"Clinics Mother Child Health"},{"issue":"2","key":"pone.0298319.ref013","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1016\/S2214-109X(15)00275-2","article-title":"National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis","volume":"4","author":"H Blencowe","year":"2016","journal-title":"The Lancet Global Health"},{"issue":"1","key":"pone.0298319.ref014","first-page":"1","article-title":"Global report on preterm birth and stillbirth (3 of 7): evidence for the effectiveness of interventions.","volume":"10","author":"FC Barros","year":"2010","journal-title":"BMC pregnancy and childbirth."},{"issue":"1","key":"pone.0298319.ref015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.30699\/jogcr.7.1.45","article-title":"Maternal and neonatal outcomes in cases of premature preterm rupture of membranes and the effect of latency periods (rupture of membranes to delivery) on adverse pregnancy outcomes.","volume":"7","author":"Z Akbarian Rad","year":"2022","journal-title":"Journal of Obstetrics, Gynecology and Cancer Research (JOGCR)."},{"issue":"2","key":"pone.0298319.ref016","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5847\/wjem.j.1920-8642.2016.02.011","article-title":"Maternal and fetal outcomes in terms of premature rupture of membrane","volume":"7","author":"T Endale","year":"2016","journal-title":"World journal of emergency medicine"},{"issue":"5","key":"pone.0298319.ref017","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1515\/jpm-2017-0027","article-title":"Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.","volume":"46","author":"M Tchirikov","year":"2018","journal-title":"Journal of perinatal medicine"},{"issue":"2","key":"pone.0298319.ref018","first-page":"77","article-title":"Evaluation of maternal risk factors, delivery, and neonatal outcomes of premature rupture of membrane: A systematic review study","volume":"7","author":"H Boskabadi","year":"2019","journal-title":"Journal of Pediatrics Review"},{"issue":"2","key":"pone.0298319.ref019","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajog.2015.09.093","article-title":"Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes","volume":"214","author":"AM Faucett","year":"2016","journal-title":"American journal of obstetrics and gynecology"},{"key":"pone.0298319.ref020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-020-02031-x","article-title":"Incidence and predictors of neonatal mortality among neonates admitted in Amhara regional state referral hospitals, Ethiopia: a prospective follow-up study.","volume":"20","author":"BA Mengistu","year":"2020","journal-title":"BMC Pediatrics"},{"key":"pone.0298319.ref021","author":"RA Aziz","year":"2017","journal-title":"Risk-adjusted multi-stage Bayesian performance monitoring model for maternal healthcare"},{"issue":"1","key":"pone.0298319.ref022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-019-4387-9","article-title":"Adverse birth outcomes and its associated factors among women who delivered in North Wollo zone, northeast Ethiopia: a facility based cross-sectional study.","volume":"12","author":"EA Kassahun","year":"2019","journal-title":"BMC Research Notes."},{"issue":"2","key":"pone.0298319.ref023","first-page":"1","article-title":"Interpregnancy Interval and Adverse Birth Outcome in Term Premature Rupture of Membrane, 2017.","volume":"5","author":"Y Workineh","year":"2019","journal-title":"The Korean Journal of Food & Health Convergence."},{"issue":"1","key":"pone.0298319.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2393-14-90","article-title":"Adverse birth outcomes among deliveries at Gondar University Hospital, Northwest Ethiopia.","volume":"14","author":"AA Adane","year":"2014","journal-title":"BMC pregnancy and childbirth."},{"issue":"2","key":"pone.0298319.ref025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jpag.2019.10.006","article-title":"Risk factors and birth outcomes associated with teenage pregnancy: a Canadian sample","volume":"33","author":"SP Wong","year":"2020","journal-title":"Journal of pediatric and adolescent gynecology"},{"issue":"4","key":"pone.0298319.ref026","first-page":"165","article-title":"Maternal and perinatal outcome of pregnancies with preterm premature rupture of membranes (PPROM) at Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia.","volume":"52","author":"B Sirak","year":"2014","journal-title":"Ethiop Med J"},{"issue":"4","key":"pone.0298319.ref027","doi-asserted-by":"crossref","first-page":"e0122564","DOI":"10.1371\/journal.pone.0122564","article-title":"Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network.","volume":"10","author":"K Hanke","year":"2015","journal-title":"PloS one"},{"issue":"4","key":"pone.0298319.ref028","first-page":"324","article-title":"Prevalence and associated factors of adverse birth outcomes among women attended maternity ward at Negest Elene Mohammed Memorial General Hospital in Hosanna Town, SNNPR, Ethiopia.","volume":"5","author":"R Abdo","year":"2016","journal-title":"J Women\u2019s Health Care"},{"issue":"5","key":"pone.0298319.ref029","first-page":"259","article-title":"Determinants of adverse birth outcome among mothers who gave birth at hospitals in Gamo Gofa zone, southern Ethiopia: a facility based case-control study.","volume":"25","author":"F Gebremeskel","year":"2017","journal-title":"Qual Prim Care."},{"issue":"1","key":"pone.0298319.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-00349-2","article-title":"Agricultural pesticide use and adverse birth outcomes in the San Joaquin Valley of California","volume":"8","author":"AE Larsen","year":"2017","journal-title":"Nature communications"},{"issue":"1","key":"pone.0298319.ref031","first-page":"33","article-title":"Association of Maternal Lower Urinary Tract Infection with Adverse Fetal Outcome in Terms of Preterm Labor and Low Birth Weight.","volume":"7","author":"F Iqbal","year":"2017","journal-title":"J Soc Obstet Gynaecol Pak."},{"key":"pone.0298319.ref032","volume-title":"WHO recommendations on antenatal care for a positive pregnancy experience:","author":"World Health Organization","year":"2016"},{"issue":"2","key":"pone.0298319.ref033","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3329\/jssmc.v11i2.49301","article-title":"Effect of Anemia on Pregnancy Outcome in Labour Ward: Study in a Tertiary Level Public Hospital","volume":"11","author":"A Perveen","year":"2019","journal-title":"Journal of Shaheed Suhrawardy Medical College"},{"issue":"3","key":"pone.0298319.ref034","first-page":"626","article-title":"Maternal morbidity and perinatal outcome in preterm premature rupture of membranes before 37 weeks gestation","volume":"30","author":"S Dars","year":"2014","journal-title":"Pakistan journal of medical sciences"},{"key":"pone.0298319.ref035","first-page":"1","article-title":"Adverse Birth Out Comes and Associated Factors among Delivered Mothers in Dessie Referral Hospital.","author":"N Cherie","year":"2018","journal-title":"North-East Ethiopia."},{"issue":"1","key":"pone.0298319.ref036","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/TJOG.TJOG_89_18","article-title":"Maternal and neonatal outcomes in premature rupture of membranes at University of Maiduguri Teaching Hospital, Maiduguri, North-Eastern Nigeria.","volume":"36","author":"A Idrisa","year":"2019","journal-title":"Tropical Journal of Obstetrics and Gynaecology"},{"issue":"1","key":"pone.0298319.ref037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/OLQ.0000000000000062","article-title":"Risk Factors for Congenital Syphilis and Adverse Pregnancy Outcomes in Offspring of Women With Syphilis in Shenzhen, China.","volume":"41","author":"J-B Qin","year":"2014","journal-title":"Sexually transmitted diseases."},{"issue":"6","key":"pone.0298319.ref038","doi-asserted-by":"crossref","first-page":"560","DOI":"10.11648\/j.ijnfs.20140306.21","article-title":"Prevalence and factors associated with low birth weight in Axum and Laelay Maichew districts, North Ethiopia: a comparative cross-sectional study","volume":"3","author":"N Teklehaimanot","year":"2014","journal-title":"Int J Nutr Food Sci"},{"key":"pone.0298319.ref039","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pmedr.2018.05.011","article-title":"Birth history as a predictor of adverse birth outcomes: Evidence from state vital statistics data.","volume":"11","author":"D Su","year":"2018","journal-title":"Preventive medicine reports."},{"issue":"6","key":"pone.0298319.ref040","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s10995-015-1904-x","article-title":"Previous adverse infant outcomes as predictors of preconception care use: an analysis of the 2010 and 2012 Los Angeles mommy and baby (LAMB) surveys.","volume":"20","author":"P Batra","year":"2016","journal-title":"Maternal and child health journal"},{"issue":"2","key":"pone.0298319.ref041","first-page":"221","article-title":"Interpregnancy interval following miscarriage and adverse pregnancy outcomes: systematic review and meta-analysis","volume":"23","author":"C Kangatharan","year":"2017","journal-title":"Human reproduction update"}],"container-title":["PLOS 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