{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:41:31Z","timestamp":1793320891791,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["MS22021044"],"award-info":[{"award-number":["MS22021044"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Prostate stem cell antigen (PSCA) is associated with disease progression, promotion of angiogenesis, invasion, metastasis and immune evasion in cancer. However, its expression pattern and diagnostic and prognostic potential have not been thoroughly analysed from a pan-cancer perspective. This study aimed to examine the effects of PSCA on the prognosis and inflammatory cell infiltration patterns of various cancer types. We analysed the relationship between PSCA expression and immunological subtypes in tumor microenvironment (TME) and the role of molecular subtypes, potentially promising immune biomarkers and tumour-infiltrating lymphocytes (TILs) in various cancer types, especially lung adenocarcinoma (LUAD). In addition, we investigated the prognostic significance of PSCA expression in LUAD. The co-expression network of PSCA was found to be mainly involved in the regulation of immune responses and antigen processing and expression and was significantly enriched in pathological and substance metabolism-related pathways in cancer. Altogether, this study reveals that PSCA is a promising target for immunotherapy in patients with cancer.<\/jats:p>","DOI":"10.1371\/journal.pone.0298469","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T19:05:29Z","timestamp":1719342329000},"page":"e0298469","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pan-cancer analysis of PSCA that is associated with immune infiltration and affects patient prognosis"],"prefix":"10.1371","volume":"19","author":[{"given":"Chenxing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-732X","authenticated-orcid":true,"given":"Ziheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-1209","authenticated-orcid":true,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"pone.0298469.ref001","unstructured":"K Y, M S, E M, et al.\u2014Inferring tumour purity and stromal and immune cell admixture from expression. D\u2014101528555 (- 2041\u20131723 (Electronic)):- 2612."},{"key":"pone.0298469.ref002","doi-asserted-by":"crossref","unstructured":"L L, E L, L L, et al.\u2014PSCA regulates IL-6 expression through p38\/NF-\u03baB signaling in prostate cancer.\u2014Prostate 2017 Oct;77(14):1389\u20131400 101002\/pros23399 Epub 2017 Aug 28 (- 1097\u20130045 (Electronic)):- 1389\u2013400.","DOI":"10.1002\/pros.23399"},{"key":"pone.0298469.ref003","unstructured":"ML M, MA T, Y K, et al.\u2014Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without. D\u20148101368 (- 0270\u20134137 (Print)):- 139\u201351."},{"key":"pone.0298469.ref004","unstructured":"V L, F B, A S, et al.\u2014Gene identification for risk of relapse in stage I lung adenocarcinoma patients. D\u2014101532965 (- 1949\u20132553 (Electronic)):- 30561\u201374."},{"key":"pone.0298469.ref005","unstructured":"P G-H, Id O, R R-O, et al.\u2014Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated. D\u20140403234 (- 1573\u20134978 (Electronic)):- 9239\u201343."},{"key":"pone.0298469.ref006","unstructured":"Q X, Z Z, L L, et al.\u2014The Correlation between PSCA Expression and Neuroendocrine Differentiation in. D\u2014101600173 (- 2314\u20136141 (Electronic)):- 5395312."},{"key":"pone.0298469.ref007","unstructured":"W J, A A, Id O, et al.\u2014Targeted RNAi of BIRC5\/Survivin Using Antibody-Conjugated Poly(Propylene. D\u2014101534003 (- 1999\u20134923 (Print)):T\u2014epublish."},{"key":"pone.0298469.ref008","unstructured":"X W, Y L, J L, et al.\u2014PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen. D\u2014101570526 (- 2162\u20134011 (Print)):- e1284722."},{"key":"pone.0298469.ref009","unstructured":"Y U, Id O, K M, et al.\u2014Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer. D\u20149607688 (- 1349\u20139092 (Electronic)):- 12\u201320."},{"key":"pone.0298469.ref010","first-page":"9121478","article-title":"Construction of miRNA-mRNA-TF Regulatory Network for Diagnosis of Gastric Cancer","volume":"2021","author":"Z F","year":"2021","journal-title":"Biomed Res Int"},{"key":"pone.0298469.ref011","unstructured":"K D, L W, Y L, et al.\u2014A deep learning-based system for survival benefit prediction of tyrosine kinase. D\u2014101733727 (- 2589\u20135370 (Electronic)):- 101541."},{"key":"pone.0298469.ref012","unstructured":"S T, Y Z, X L, et al.\u2014CLEC10A can serve as a potential therapeutic target and its level correlates with. D\u2014101531236 (- 1792\u20131082 (Electronic)):- 285."},{"key":"pone.0298469.ref013","unstructured":"AM N, CL L, MR G, et al.\u2014Robust enumeration of cell subsets from tissue expression profiles. D\u2014101215604 (- 1548\u20137105 (Electronic)):- 453\u20137."},{"key":"pone.0298469.ref014","unstructured":"E K, Id O, N P, et al.\u2014TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease. D\u20142985117r (- 1550\u20136606 (Electronic)):- 3570\u201380."},{"key":"pone.0298469.ref015","unstructured":"M Z, J L, C C.\u2014High expression of ZFP36L2 correlates with the prognosis and immune infiltration. D\u2014101560621 (- 1664\u20138021 (Print)):- 914219."},{"key":"pone.0298469.ref016","doi-asserted-by":"crossref","first-page":"2262014","DOI":"10.1155\/2022\/2262014","article-title":"A Prognostic Risk Model of a Novel Oxidative Stress-Related Signature Predicts Clinical Prognosis and Demonstrates Immune Relevancy in Lung Adenocarcinoma","volume":"2022","author":"X Huang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"pone.0298469.ref017","unstructured":"SA F, G B, S B, et al.\u2014The Catalogue of Somatic Mutations in Cancer (COSMIC). D\u2014101287858 (- 1934\u20138258 (Electronic)):- Unit 10.11."},{"key":"pone.0298469.ref018","unstructured":"MJ G, Id O, B C, et al.\u2014Visualizing and interpreting cancer genomics data via the Xena platform. D\u20149604648 (- 1546\u20131696 (Electronic)):- 675\u201378."},{"key":"pone.0298469.ref019","unstructured":"YR M, Id O, Q Z, et al.\u2014ImmuCellAI: A Unique Method for Comprehensive T-Cell Subsets Abundance Prediction. D\u2014101664569 (- 2198\u20133844 (Print)):- 1902880."},{"key":"pone.0298469.ref020","unstructured":"TM M, A S, AJ G, et al.\u2014Machine Learning Identifies Stemness Features Associated with Oncogenic. D\u20140413066 (- 1097\u20134172 (Electronic)):- 338-54.e15."},{"key":"pone.0298469.ref021","unstructured":"MJ G, GH dB, N L, et al.\u2014The prognostic influence of tumour-infiltrating lymphocytes in cancer: a. D\u20140370635 (- 1532\u20131827 (Electronic)):- 93\u2013103."},{"key":"pone.0298469.ref022","unstructured":"L L, Id O, M L, et al.\u2014FURIN correlated with immune infiltration serves as a potential biomarker in. D\u2014100973405 (- 1591\u20139528 (Electronic)):- 371\u201384."},{"key":"pone.0298469.ref023","doi-asserted-by":"crossref","unstructured":"B R, CN W, Y T, et al.\u2014TISIDB: an integrated repository portal for tumor-immune system interactions.\u2014Bioinformatics 2019 Oct 15;35(20):4200\u20134202 101093\/bioinformatics\/btz210 (- 1367\u20134811 (Electronic)):- 4200\u201302.","DOI":"10.1093\/bioinformatics\/btz210"},{"key":"pone.0298469.ref024","first-page":"1494520","article-title":"Comprehensive Prognostic Analysis of Immune Implication Value and Oxidative Stress Significance of NECAP2 in Low-Grade Glioma","volume":"2022","author":"Z Lu","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"pone.0298469.ref025","first-page":"8027686","article-title":"HAUS Augmin-Like Complex Subunit 1 Influences Tumour Microenvironment and Prognostic Outcomes in Glioma","volume":"2022","author":"Q Yao","year":"2022","journal-title":"J Oncol"},{"key":"pone.0298469.ref026","unstructured":"PJ H, Y Z.\u2014Survival model predictive accuracy and ROC curves. D\u20140370625 (- 0006-341X (Print)):- 92\u2013105."},{"key":"pone.0298469.ref027","unstructured":"W W, F S-C, M R.\u2014GOplot: an R package for visually combining expression data with functional. D\u20149808944 (- 1367\u20134811 (Electronic)):- 2912\u20134."},{"key":"pone.0298469.ref028","unstructured":"H O, S G, K S, et al.\u2014KEGG: Kyoto Encyclopedia of Genes and Genomes. D\u20140411011 (- 0305\u20131048 (Print)):- 29\u201334."},{"key":"pone.0298469.ref029","unstructured":"D W, J L, R Z, et al.\u2014PSCA is a target of chimeric antigen receptor T cells in gastric cancer. D\u2014101607860 (- 2050\u20137771 (Print)):- 3."},{"key":"pone.0298469.ref030","unstructured":"JW K, KH N, SH A, et al.\u2014Prognostic implications of immunosuppressive protein expression in tumors as well. D\u2014100886238 (- 1436\u20133305 (Electronic)):- 42\u201352."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0298469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T19:05:51Z","timestamp":1719342351000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0298469"}},"subtitle":[],"editor":[{"given":"Zhijie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0298469","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]}}}