{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:22:50Z","timestamp":1781212970758,"version":"3.54.1"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Latent tuberculosis infection (LTBI) screening and treatment interventions that are tailored to optimize acceptance among the non-U.S.\u2013born population are essential for U.S. tuberculosis elimination. We investigated the impact of medical interpreter use on LTBI treatment acceptance and completion among non-U.S.\u2013born persons in a multisite study.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The Tuberculosis Epidemiologic Studies Consortium was a prospective cohort study that enrolled participants at high risk for LTBI at ten U.S. sites with 18 affiliated clinics from 2012 to 2017. Non-U.S.\u2013born participants with at least one positive tuberculosis infection test result were included in analyses. Characteristics associated with LTBI treatment offer, acceptance, and completion were evaluated using multivariable logistic regression with random intercepts to account for clustering by enrollment site. Our primary outcomes were whether use of an interpreter was associated with LTBI treatment acceptance and completion. We also evaluated whether interpreter usage was associated treatment offer and whether interpreter type was associated with treatment offer, acceptance, or completion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among 8,761 non-U.S.\u2013born participants, those who used an interpreter during the initial interview had a significantly greater odds of accepting LTBI treatment than those who did not use an interpreter. There was no association between use of an interpreter and a clinician\u2019s decision to offer treatment or treatment completion once accepted. Characteristics associated with lower odds of treatment being offered included experiencing homelessness and identifying as Pacific Islander persons. Lower treatment acceptance was observed in Black and Latino persons and lower treatment completion by participants experiencing homelessness. Successful treatment completion was associated with use of shorter rifamycin-based regimens. Interpreter type was not associated with LTBI treatment offer, acceptance, or completion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We found greater LTBI treatment acceptance was associated with interpreter use among non-U.S.\u2013born individuals.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0298628","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T17:41:22Z","timestamp":1713289282000},"page":"e0298628","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interpreter usage and associations with latent tuberculosis infection treatment acceptance and completion in the USA among non-U.S.\u2013born persons, 2012\u20132017"],"prefix":"10.1371","volume":"19","author":[{"given":"Rebeca","family":"Gonzalez-Reyes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoseph","family":"Sorri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-9099","authenticated-orcid":true,"given":"David J.","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Tuberculosis Epidemiologic Studies Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"10","key":"pone.0298628.ref001","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1016\/S1473-3099(17)30248-7","article-title":"Latent tuberculosis infection: the final frontier of tuberculosis elimination in the USA","volume":"17","author":"PA LoBue","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"pone.0298628.ref002","doi-asserted-by":"crossref","first-page":"441","DOI":"10.15585\/mmwr.mm7112a1","article-title":"Tuberculosis\u2014United States, 2021","volume":"71","author":"TD Filardo","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"4","key":"pone.0298628.ref003","doi-asserted-by":"crossref","first-page":"248","DOI":"10.7326\/M17-0609","article-title":"Treatment of Latent Tuberculosis Infection: An Updated Network Meta-analysis","volume":"167","author":"D Zenner","year":"2017","journal-title":"Ann Intern Med"},{"issue":"10","key":"pone.0298628.ref004","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/cid\/ciac248","article-title":"Evaluation of the Latent Tuberculosis Care Cascade Among Public Health Clinics in the United States","volume":"75","author":"SB Holzman","year":"2022","journal-title":"Clin Infect Dis"},{"key":"pone.0298628.ref005","article-title":"The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis","author":"H Alsdurf","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"pone.0298628.ref006","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1164\/rccm.201508-1683OC","article-title":"The Prevalence of Latent Tuberculosis Infection in the United States","volume":"194","author":"JD Mancuso","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"pone.0298628.ref007","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1475-6773.2006.00629.x","article-title":"Do professional interpreters improve clinical care for patients with limited English proficiency? 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