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Recently, GPX2 has been identified as a candidate gene for backfat and feed efficiency in pigs. However, it is unclear whether GPX2 regulates the development of porcine preadipocytes and skeletal muscle cells. In this study, adenoviral gene transfer was used to overexpress\n                    <jats:italic>GPX2<\/jats:italic>\n                    . Our findings suggest that overexpression of\n                    <jats:italic>GPX2<\/jats:italic>\n                    gene inhibited proliferation of porcine preadipocytes. And the process is accompanied by the reduction of the p-p38.\n                    <jats:italic>GPX2<\/jats:italic>\n                    inhibited adipogenic differentiation and promoted lipid degradation, while ERK1\/2 was reduced and p-p38 was increased. Proliferation of porcine skeletal muscle cells was induced after\n                    <jats:italic>GPX2<\/jats:italic>\n                    overexpression, was accompanied by activation in JNK, ERK1\/2, and p-p38. Overexpression methods confirmed that\n                    <jats:italic>GPX2<\/jats:italic>\n                    has a promoting function in myoblastic differentiation. ERK1\/2 pathway was activated and p38 was suppressed during the process. This study lays a foundation for the functional study of\n                    <jats:italic>GPX2<\/jats:italic>\n                    and provides theoretical support for promoting subcutaneous fat reduction and muscle growth.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0298827","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:45:33Z","timestamp":1715262333000},"page":"e0298827","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Overexpression of GPX2 gene regulates the development of porcine preadipocytes and skeletal muscle cells through MAPK signaling 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