{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:23:09Z","timestamp":1782487389678,"version":"3.54.5"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI19\/01700 and RD21\/0016\/0027"],"award-info":[{"award-number":["PI19\/01700 and RD21\/0016\/0027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To analyse trends in urinary tract infection (UTIs) hospitalisation among patients adults 18\u201365 aged in Spain from 2000\u20132015.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective observational study using the Spanish Hospitalisation Minimum Data Set (CMBD), with codifications by the International Classification of Diseases (ICD-9). Variables: Type of UTIs (pyelonephritis, prostatitis, cystitis and non-specific-UTIs), sex, age (in 5 categories: 18\u201349 and 50\u201364 years in men, and 18\u201344, 45\u201355 and 56\u201364 years in women), comorbidity, length of stay, costs and mortality associated with admission. The incidence of hospitalisation was studied according to sex, age group and type of UTIs per 100,000. Trends were identified using Joinpoint regression.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>From 2000\u20132015, we found 259,804 hospitalisations for UTIs (51.6% pyelonephritis, 7.5% prostatitis, 0.6% cystitis and 40.3% non-specific UTIs). Pyelonephritis predominated in women and non-specific UTIs in men. The hospital stay and the average cost (2,160 EUR (IQR 1,7872,540 were greater in men. Overall mortality (0.4%) was greater in non-specific UTIs. More women were admitted (rates of 79.4 to 81.7) than in men (30.2 to 41). The greatest increase was found in men aged 50\u201364 years (from 59.3 to 87). In the Joinpoint analysis, the incidence of pyelonephritis increased in women [AAPC 2.5(CI 95% 1.6;3.4)], and non-specific UTIs decreased [AAPC \u22122.2(CI 95% \u22123.3;-1.2)]. Pyelonephritis decreased in men [AAPC \u22120.5 (CI 95% \u22121.5;0.5)] and non-specific UTIs increased [AAPC 2.3 (CI 95% 1.9;2.6)] and prostatitis increased [AAPC 2.6 (CI 95% 1.4;3.7)].<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The urinary infection-related hospitalisation rate in adults in Spain increased during the period 2000\u20132015. Pyelonephritis predominated in women and non-specific UTIs in men. The highest hospitalisation rates occurred in the women but the greatest increase was found in men aged 65\u201374. The lenght of stay and cost were higher in men.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0298931","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T18:24:16Z","timestamp":1713291856000},"page":"e0298931","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Trends in hospitalisation for urinary tract infection in adults aged 18\u201365 by sex in Spain: 2000 to 2015"],"prefix":"10.1371","volume":"19","author":[{"given":"Jes\u00fas","family":"Redondo-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0440-6588","authenticated-orcid":true,"given":"Ricardo","family":"Rodr\u00edguez-Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-893X","authenticated-orcid":true,"given":"M\u00aa del Canto","family":"de-Hoyos-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-2805","authenticated-orcid":true,"given":"Cristina","family":"Munta\u00f1ola-Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Almendro Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Pe\u00f1alver-Arg\u00fceso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fern\u00e1ndez-Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Gil-de Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"del Cura-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"5","key":"pone.0298931.ref001","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: epidemiology, mechanisms of infection and treatment options","volume":"13","author":"AL Flores-Mireles","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"pone.0298931.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2013.09.003","article-title":"Urinary Tract Infection Syndromes","volume":"28","author":"B. Foxman","year":"2014","journal-title":"Infect Dis Clin North Am"},{"key":"pone.0298931.ref003","doi-asserted-by":"crossref","first-page":"175628721983217","DOI":"10.1177\/1756287219832172","article-title":"An introduction to the epidemiology and burden of urinary tract infections.","volume":"11","author":"M Medina","year":"2019","journal-title":"Ther Adv Urol"},{"key":"pone.0298931.ref004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1157\/13091442","article-title":"Epidemiolog\u00eda y etiolog\u00eda de la infecci\u00f3n urinaria comunitaria. Sensibilidad antimicrobiana de los principales pat\u00f3genos y significado cl\u00ednico de la resistencia","volume":"23","author":"J. 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