{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:38:53Z","timestamp":1793835533174,"version":"4.6.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J01087"],"award-info":[{"award-number":["2020J01087"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fengze District Science and Technology Bureau Project","award":["2020Z34"],"award-info":[{"award-number":["2020Z34"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Meta-analysis was conducted to examine the effect of supplemental curcumin intake on skeletal muscle injury status and to propose an optimal intervention program.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In accordance with the procedures specified in the PRISMA statement for systematic reviews and meta-analyses of randomized controlled trials, the Review Manager 5.3 was used to analyze the results of creatine kinase (CK), muscle soreness, interleukin-6 (IL-6), and range of motion (ROM) as outcome indicators in the 349 subjects included in the 14 articles.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The effect size of curcumin supplementation on muscle soreness, mean difference (MD) = -0.61; the relationship between curcumin supplementation and muscle soreness for time of measurement (I<jats:sup>2<\/jats:sup> = 83.6%)\u3001the relationship between curcumin supplementation and muscle soreness for period of intervention (I<jats:sup>2<\/jats:sup> = 26.2%)\u3001the relationship between whether one had been trained (I<jats:sup>2<\/jats:sup> = 0%) and supplementation dose (I<jats:sup>2<\/jats:sup> = 0%) were not heterogeneous for the relationship between curcumin supplementation and muscle soreness; The effect size on CK, MD = -137.32; the relationship between curcumin supplementation and CK (I<jats:sup>2<\/jats:sup> = 79.7%)\u3001intervention period (I<jats:sup>2<\/jats:sup> = 91.9%)\u3001whether or not trained (I<jats:sup>2<\/jats:sup> = 90.7%)\u3001and no heterogeneity in the relationship between curcumin supplementation and CK for the time of measurement (I<jats:sup>2<\/jats:sup> = 0%); The effect size MD = 4.10 for the effect on ROM; The effect size for IL-6 was MD = -0.33.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This meta-analysis highlights that curcumin supplementation significantly mitigates skeletal muscle damage, with notable improvements in CK levels, muscle soreness, IL-6 levels, and ROM. The results highlight the importance of curcumin dosage and timing, revealing that prolonged supplementation yields the best results, especially for untrained individuals or those less exposed to muscle-damaging exercise. For muscle soreness and ROM enhancement, a pre-emptive, low-dose regimen is beneficial, while immediate post-exercise supplementation is most effective at reducing CK and IL-6 levels.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0299135","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T17:38:51Z","timestamp":1721065131000},"page":"e0299135","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status"],"prefix":"10.1371","volume":"19","author":[{"given":"Xiaoyang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3235-7669","authenticated-orcid":true,"given":"Lihan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"issue":"1","key":"pone.0299135.ref001","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/17461391.2018.1505957","article-title":"Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions?","volume":"19","author":"DJ Owens","year":"2019","journal-title":"European Journal of Sport Science"},{"issue":"3","key":"pone.0299135.ref002","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-201x.2001.00835.x","article-title":"Excitation-induced Ca2+ influx and skeletal muscle cell damage","volume":"171","author":"H Gissel","year":"2001","journal-title":"Acta Physiologica Scandinavica"},{"issue":"6","key":"pone.0299135.ref003","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10974-015-9438-9","article-title":"The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes","volume":"36","author":"M Kozakowska","year":"2015","journal-title":"Journal of Muscle Research and Cell Motility"},{"issue":"5","key":"pone.0299135.ref004","doi-asserted-by":"crossref","DOI":"10.1249\/MSS.0000000000001196","article-title":"Etiology and Recovery of Neuromuscular Fatigue after Simulated Soccer Match Play.","volume":"49","author":"K Thomas","year":"2017","journal-title":"Medicine & Science in Sports & Exercise"},{"key":"pone.0299135.ref005","doi-asserted-by":"crossref","first-page":"100448","DOI":"10.1016\/j.obmed.2022.100448","article-title":"The effect of eight weeks of Pilates with curcumin supplementation on liver enzymes and lipid profile in overweight and obese women","volume":"36","author":"Z. Porasgari","year":"2022","journal-title":"Obesity Medicine"},{"issue":"11","key":"pone.0299135.ref006","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin: From ancient medicine to current clinical trials","volume":"65","author":"H. Hatcher","year":"2008","journal-title":"Cellular & Molecular Life Sciences"},{"issue":"7","key":"pone.0299135.ref007","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.freeradbiomed.2005.11.003","article-title":"Iron chelation in the biological activity of curcumin","volume":"40","author":"Y. Jiao","year":"2006","journal-title":"Free Radical Biology and Medicine"},{"issue":"6","key":"pone.0299135.ref008","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1249\/01.mss.0000560765.09624.0e","article-title":"Curcumin Supplementation Alters Inflammatory Cytokines Following Exercise.","volume":"51","author":"BK McFarlin","year":"2019","journal-title":"MEDICINE AND SCIENCE IN SPORTS AND EXERCISE"},{"issue":"6","key":"pone.0299135.ref009","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/19390211.2021.1936335","article-title":"Short Term, Oral Supplementation with Optimized Curcumin Does Not Impair Performance Improvements Associated with High Intensity Interval Training","volume":"19","author":"JN Kisiolek","year":"2022","journal-title":"JOURNAL OF DIETARY SUPPLEMENTS"},{"issue":"1","key":"pone.0299135.ref010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/bmb\/ldm014","article-title":"Creatine kinase monitoring in sport medicine","volume":"81-82","author":"B. Paola","year":"2007","journal-title":"Br Med Bull"},{"issue":"4","key":"pone.0299135.ref011","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jsams.2020.10.004","article-title":"The effect of exercise intensity on chronic inflammation: A systematic review and meta-analysis[J]","volume":"24","author":"L Rose G","year":"2021","journal-title":"Journal of Science and Medicine in Sport"},{"issue":"3","key":"pone.0299135.ref012","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.scispo.2021.05.002","article-title":"Effect of curcumin supplementation on muscle damage, antioxidant status and inflammatory factors after successive simulated taekwondo competitions","volume":"37","author":"M Ghojazadeh","year":"2022","journal-title":"SCIENCE & SPORTS"},{"issue":"6","key":"pone.0299135.ref013","article-title":"Short Term, Oral Supplementation with Optimized Curcumin Does Not Impair Performance Improvements Associated with High Intensity Interval Training","volume":"19","author":"KJ N","year":"2021","journal-title":"Journal of dietary supplements"},{"issue":"3","key":"pone.0299135.ref014","article-title":"Ten Days of Curcumin Supplementation Attenuates Subjective Soreness and Maintains Muscular Power Following Plyometric Exercise","volume":"19","author":"HA R","year":"2021","journal-title":"Journal of dietary supplements"},{"issue":"5","key":"pone.0299135.ref015","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/19390211.2020.1796885","article-title":"Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation","volume":"18","author":"AR Mallard","year":"2021","journal-title":"Journal of Dietary Supplements"},{"issue":"5","key":"pone.0299135.ref016","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/jmf.2019.4533","article-title":"The Effects of Bioavailable Curcumin (Cureit) on Delayed Onset Muscle Soreness Induced By Eccentric Continuous Exercise: A Randomized, Placebo-Controlled, Double-Blind Clinical Study","volume":"23","author":"A Amalraj","year":"2020","journal-title":"J Med Food"},{"issue":"7","key":"pone.0299135.ref017","doi-asserted-by":"crossref","DOI":"10.3390\/nu11071692","article-title":"Eight Weeks of a High Dose of Curcumin Supplementation May Attenuate Performance Decrements Following Muscle-Damaging Exercise.","volume":"11","author":"R Jager","year":"2019","journal-title":"NUTRIENTS"},{"issue":"1","key":"pone.0299135.ref018","doi-asserted-by":"crossref","DOI":"10.3177\/jnsv.65.82","article-title":"Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men","volume":"65","author":"Y Tanabe","year":"2019","journal-title":"Journal of Nutritional Science and Vitaminology"},{"issue":"4","key":"pone.0299135.ref019","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/sms.13373","article-title":"Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation","volume":"29","author":"Y Tanabe","year":"2019","journal-title":"SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS"},{"issue":"9","key":"pone.0299135.ref020","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00421-015-3170-4","article-title":"Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin","volume":"115","author":"Y Tanabe","year":"2015","journal-title":"EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY"},{"key":"pone.0299135.ref021","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbacli.2016.02.003","article-title":"Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin.","volume":"5","author":"BK McFarlin","year":"2016","journal-title":"BBA Clin"},{"issue":"8","key":"pone.0299135.ref022","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00421-015-3152-6","article-title":"Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).","volume":"115","author":"LM Nicol","year":"2015","journal-title":"European Journal of Applied Physiology"},{"issue":"4","key":"pone.0299135.ref023","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/19390211.2019.1604604","article-title":"Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage, and Muscle Soreness.","volume":"17","author":"PHS Waldman","year":"2020","journal-title":"Journal of Dietary Supplements"},{"key":"pone.0299135.ref024","first-page":"11","article-title":"Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva (R)): a randomised, placebo-controlled trial.","author":"F Drobnic","year":"2014","journal-title":"JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION"},{"issue":"2","key":"pone.0299135.ref025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.18869\/acadpub.aassjournal.4.2.25","article-title":"The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS).","volume":"4","author":"B Nakhostin-Roohi","year":"2016","journal-title":"Annals of Applied Sport Science"},{"issue":"2","key":"pone.0299135.ref026","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s000110050284","article-title":"Anti-inflammatory drugs and their mechanism of action","volume":"47","author":"JR Vane","year":"1998","journal-title":"Inflammation Research"},{"issue":"1","key":"pone.0299135.ref027","first-page":"147","article-title":"Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial.","volume":"16","author":"B Delecroix","year":"2017","journal-title":"JOURNAL OF SPORTS SCIENCE AND MEDICINE"},{"issue":"12","key":"pone.0299135.ref028","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1021\/ja809217u","article-title":"Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin","volume":"131","author":"J Barry","year":"2009","journal-title":"J Am Chem Soc"},{"issue":"6","key":"pone.0299135.ref029","doi-asserted-by":"crossref","first-page":"R2168","DOI":"10.1152\/ajpregu.00858.2006","article-title":"Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage","volume":"292","author":"JM Davis","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"pone.0299135.ref030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1254\/jphs.10126SC","article-title":"Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-\u03baB in human lung epithelial cells","volume":"114","author":"K Moriyuki","year":"2010","journal-title":"J Pharmacol Sci"},{"issue":"6","key":"pone.0299135.ref031","first-page":"469","article-title":"Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans.","volume":"35","author":"M Takahashi","year":"2014","journal-title":"INTERNATIONAL JOURNAL OF SPORTS MEDICINE"},{"key":"pone.0299135.ref032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-46401-5","volume-title":"The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease","author":"BB Aggarwal","year":"2007"},{"issue":"4","key":"pone.0299135.ref033","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3109\/10582452.2013.848967","article-title":"Visual analog scale and pressure pain threshold for delayed onset muscle soreness assessment","volume":"21","author":"WY Lau","year":"2013","journal-title":"Journal of Musculoskeletal Pain"},{"key":"pone.0299135.ref034","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3389\/fphys.2017.00779","article-title":"Acute and Chronic Effects of Endurance Running on Inflammatory Markers: A Systematic Review.","volume":"8","author":"ES Barros","year":"2017","journal-title":"Front Physiol"},{"key":"pone.0299135.ref035","doi-asserted-by":"crossref","DOI":"10.1186\/s12970-014-0066-3","article-title":"The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling.","volume":"12","author":"JN Sciberras","year":"2015","journal-title":"JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION"},{"key":"pone.0299135.ref036","article-title":"Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets","author":"JW Cho","year":"2007","journal-title":"International Journal of Molecular Medicine"},{"issue":"4","key":"pone.0299135.ref037","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1123\/ijsnem.11.4.503","article-title":"Pre-exercise carbohydrate status and immune responses to prolonged cycling: II. Effect on plasma cytokine concentration","volume":"11","author":"NC Bishop","year":"2001","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"8","key":"pone.0299135.ref038","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1007\/s00394-022-02943-7","article-title":"Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review","volume":"61","author":"K Nanavati","year":"2022","journal-title":"EUROPEAN JOURNAL OF NUTRITION"},{"issue":"6","key":"pone.0299135.ref039","doi-asserted-by":"crossref","first-page":"R667","DOI":"10.1152\/ajpregu.00336.2011","article-title":"Resistance exercise increases NF-\u03baB activity in human skeletal muscle","volume":"302","author":"L Vella","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"pone.0299135.ref040","article-title":"Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review.","author":"D Fern\u00e1ndez-L\u00e1zaro","year":"2020","journal-title":"In: Nutrients"},{"key":"pone.0299135.ref041","doi-asserted-by":"crossref","first-page":"101471","DOI":"10.1016\/j.redox.2020.101471","article-title":"Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights","volume":"35","author":"SA Mason","year":"2020","journal-title":"Redox Biology"},{"key":"pone.0299135.ref042","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/978-0-387-46401-5_21","volume-title":"The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease","author":"C Hsu","year":"2007"},{"issue":"12","key":"pone.0299135.ref043","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2165\/11594400-000000000-00000","article-title":"Antioxidant supplementation during exercise training: beneficial or detrimental?","volume":"41","author":"TT Peternelj","year":"2011","journal-title":"Sports Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0299135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T17:39:52Z","timestamp":1721065192000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0299135"}},"subtitle":[],"editor":[{"given":"Roy P.","family":"Planalp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":43,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0299135","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]}}}