{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:54:57Z","timestamp":1778003697320,"version":"3.51.4"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Science","award":["UM1TR004528"],"award-info":[{"award-number":["UM1TR004528"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Cauda equina syndrome (CES) is a lumbosacral surgical emergency that has been associated with chiropractic spinal manipulation (CSM) in case reports. However, identifying if there is a potential causal effect is complicated by the heightened incidence of CES among those with low back pain (LBP). The study hypothesis was that there would be no increase in the risk of CES in adults with LBP following CSM compared to a propensity-matched cohort following physical therapy (PT) evaluation without spinal manipulation over a three-month follow-up period.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A query of a United States network (TriNetX, Inc.) was conducted, searching health records of more than 107 million patients attending academic health centers, yielding data ranging from 20 years prior to the search date (July 30, 2023). Patients aged 18 or older with LBP were included, excluding those with pre-existing CES, incontinence, or serious pathology that may cause CES. Patients were divided into two cohorts: (1) LBP patients receiving CSM or (2) LBP patients receiving PT evaluation without spinal manipulation. Propensity score matching controlled for confounding variables associated with CES.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>67,220 patients per cohort (mean age 51 years) remained after propensity matching. CES incidence was 0.07% (95% confidence intervals [CI]: 0.05\u20130.09%) in the CSM cohort compared to 0.11% (95% CI: 0.09\u20130.14%) in the PT evaluation cohort, yielding a risk ratio and 95% CI of 0.60 (0.42\u20130.86; <jats:italic>p<\/jats:italic> = .0052). Both cohorts showed a higher rate of CES during the first two weeks of follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These findings suggest that CSM is not a risk factor for CES. Considering prior epidemiologic evidence, patients with LBP may have an elevated risk of CES independent of treatment. These findings warrant further corroboration. In the meantime, clinicians should be vigilant to identify LBP patients with CES and promptly refer them for surgical evaluation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0299159","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T17:31:30Z","timestamp":1710178290000},"page":"e0299159","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between chiropractic spinal manipulation and cauda equina syndrome in adults with low back pain: Retrospective cohort study of US academic health centers"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-1076","authenticated-orcid":true,"given":"Robert J.","family":"Trager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony N.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime A.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery A.","family":"Dusek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romeo-Paolo T.","family":"Perfecto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4941-3645","authenticated-orcid":true,"given":"Christine M.","family":"Goertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"pone.0299159.ref001","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.amjmed.2021.07.021","article-title":"Evaluation and Management of Cauda Equina Syndrome","volume":"134","author":"EO Kuris","year":"2021","journal-title":"Am J Med"},{"key":"pone.0299159.ref002","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00264-021-05273-1","article-title":"Cauda equina syndrome\u2014a practical guide to definition and classification","volume":"46","author":"C Lavy","year":"2022","journal-title":"Int Orthop"},{"key":"pone.0299159.ref003","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00586-017-4943-8","article-title":"Cauda Equina Syndrome: presentation, outcome, and predictors with focus on micturition, defecation, and sexual dysfunction","volume":"26","author":"NS Korse","year":"2017","journal-title":"Eur Spine J"},{"key":"pone.0299159.ref004","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.apmr.2009.03.021","article-title":"Cauda equina syndrome: a literature review of its definition and clinical presentation","volume":"90","author":"S Fraser","year":"2009","journal-title":"Arch Phys Med Rehabil"},{"key":"pone.0299159.ref005","doi-asserted-by":"crossref","first-page":"e414","DOI":"10.3928\/01477447-20120222-15","article-title":"Review of medicolegal cases for cauda equina syndrome: what factors lead to an adverse outcome for the provider?","volume":"35","author":"EW Daniels","year":"2012","journal-title":"Orthopedics"},{"key":"pone.0299159.ref006","first-page":"1","article-title":"What is the incidence of cauda equina syndrome? 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