{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:48:14Z","timestamp":1784958494142,"version":"3.55.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["AT009458"],"award-info":[{"award-number":["AT009458"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional abdominal pain disorders (FAPD) are the most common chronic pain conditions of childhood and are made worse by co-occurring anxiety. Our research team found that the Aim to Decrease Pain and Anxiety Treatment (ADAPT), a six-session coping skills program using cognitive behavioral therapy strategies, was effective in improving pain-related symptoms and anxiety symptoms compared to standard care. In follow-up, this current randomized clinical trial (RCT) aims to test potential neural mechanisms underlying the effect of ADAPT. Specifically, this two-arm RCT will explore changes in amygdalar functional connectivity (primary outcome) following the ADAPT protocol during the water loading symptom provocation task (WL-SPT). Secondary (e.g., changes in regional cerebral blood flow via pulsed arterial spin labeling MRI) and exploratory (e.g., the association between the changes in functional connectivity and clinical symptoms) outcomes will also be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We will include patients ages 11 to 16 years presenting to outpatient pediatric gastroenterology care at a midwestern children\u2019s hospital with a diagnosis of FAPD plus evidence of clinical anxiety based on a validated screening tool (the Generalized Anxiety Disorder-7 [GAD-7] measure). Eligible participants will undergo baseline neuroimaging involving the WL-SPT, and assessment of self-reported pain, anxiety, and additional symptoms, prior to being randomized to a six-week remotely delivered ADAPT program plus standard medical care or standard medical care alone (waitlist). Thereafter, subjects will complete a post assessment neuroimaging visit similar in nature to their first visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This small scale RCT aims to increase understanding of potential neural mechanisms of response to ADAPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov registration:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03518216\" xlink:type=\"simple\">NCT03518216<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0299170","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T13:49:06Z","timestamp":1710769746000},"page":"e0299170","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-7264","authenticated-orcid":true,"given":"Natoshia R.","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Barber Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Abounader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaina K.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Monzalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismaeel","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"Ely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"DeLano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Mulderink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Peugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Kashikar-Zuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Coghill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-8701","authenticated-orcid":true,"given":"Judith E.","family":"Arnetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"issue":"10","key":"pone.0299170.ref001","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1097\/j.pain.0000000000002601","article-title":"Amygdalar functional connectivity during resting and evoked pain in youth with functional abdominal pain disorders","volume":"163","author":"NR Cunningham","year":"2022","journal-title":"J Pain"},{"issue":"12","key":"pone.0299170.ref002","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.pain.2011.07.016","article-title":"The epidemiology of chronic pain in children and adolescents revisited: a systematic review","volume":"152","author":"S King","year":"2011","journal-title":"J Pain"},{"issue":"9","key":"pone.0299170.ref003","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.pain.2012.03.026","article-title":"Functional abdominal pain patient subtypes in childhood predict functional gastrointestinal disorders with chronic pain and psychiatric comorbidities in adolescence and adulthood","volume":"153","author":"LS Walker","year":"2012","journal-title":"J Pain"},{"issue":"2","key":"pone.0299170.ref004","first-page":"234","article-title":"Recurrent abdominal pain: a five-year follow-up study","volume":"94","author":"K St\u00f8rdal","year":"2005","journal-title":"Acta Paediatr"},{"issue":"3","key":"pone.0299170.ref005","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/MPG.0000000000000625","article-title":"Concordant parent-child reports of anxiety predict impairment in youth with functional abdominal pain","volume":"60","author":"NR Cunningham","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"pone.0299170.ref006","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00004583-200301000-00012","article-title":"Psychological comorbidity and stress reactivity in children and adolescents with recurrent abdominal pain and anxiety disorders","volume":"42","author":"LD Dorn","year":"2003","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"pone.0299170.ref007","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/jpepsy\/jsn064","article-title":"Anxiety and somatic complaints in children with recurrent abdominal pain and anxiety disorders","volume":"34","author":"LM Dufton","year":"2009","journal-title":"J Pediatr Psychol"},{"issue":"5","key":"pone.0299170.ref008","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/MPG.0000000000001342","article-title":"Using a simple risk categorization to predict outcomes in pediatric functional abdominal pain at 6 months","volume":"64","author":"NR Cunningham","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"pone.0299170.ref009","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jpeds.2016.01.018","article-title":"Anxiety Adversely Impacts Response to Cognitive Behavioral Therapy in Children with Chronic Pain","volume":"171","author":"NR Cunningham","year":"2016","journal-title":"J Pediatr"},{"issue":"1","key":"pone.0299170.ref010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MPG.0000000000001714","article-title":"Development of the Aim to Decrease Anxiety and Pain Treatment for Pediatric Functional Abdominal Pain Disorders","volume":"66","author":"NR Cunningham","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"pone.0299170.ref011","author":"HJ Lyneham","year":"2003","journal-title":"The Cool Kids Anxiety Treatment Program"},{"issue":"1","key":"pone.0299170.ref012","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/art.30644","article-title":"Cognitive behavioral therapy for the treatment of juvenile fibromyalgia: a multisite, single-blind, randomized, controlled clinical trial","volume":"64","author":"S Kashikar-Zuck","year":"2012","journal-title":"Arthritis Rheum"},{"key":"pone.0299170.ref013","volume-title":"Learning to breathe","author":"P. Broderick","year":"2013"},{"key":"pone.0299170.ref014","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpeds.2020.10.060","article-title":"Cognitive Behavior Therapy Tailored to Anxiety Symptoms Improves Pediatric Functional Abdominal Pain Outcomes: A Randomized Clinical Trial","volume":"230","author":"NR Cunningham","year":"2021","journal-title":"J Pediatr"},{"issue":"2","key":"pone.0299170.ref015","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"ME Raichle","year":"2001","journal-title":"Proceedings of the national academy of sciences"},{"issue":"47","key":"pone.0299170.ref016","doi-asserted-by":"crossref","first-page":"12165","DOI":"10.1523\/JNEUROSCI.3576-06.2006","article-title":"Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain","volume":"26","author":"MN Baliki","year":"2006","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0299170.ref017","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1523\/JNEUROSCI.4123-07.2008","article-title":"Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics","volume":"28","author":"MN Baliki","year":"2008","journal-title":"J Neurosci"},{"issue":"4","key":"pone.0299170.ref018","doi-asserted-by":"crossref","first-page":"e767","DOI":"10.1097\/PR9.0000000000000767","article-title":"Brain mechanisms impacted by psychological therapies for pain: identifying targets for optimization of treatment effects","volume":"4","author":"NR Cunningham","year":"2019","journal-title":"PAIN Reports"},{"issue":"10","key":"pone.0299170.ref019","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"RL Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"issue":"2","key":"pone.0299170.ref020","first-page":"187","article-title":"Recurrent abdominal pain: symptom subtypes based on the Rome II Criteria for pediatric functional gastrointestinal disorders","volume":"38","author":"LS Walker","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"pone.0299170.ref021","first-page":"193","article-title":"The pediatric Rome IV criteria: what\u2019s new?","volume":"11","author":"IJ Koppen","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"9","key":"pone.0299170.ref022","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"K Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"issue":"6","key":"pone.0299170.ref023","first-page":"613","article-title":"An ultra-brief screening scale for anxiety and depression: the PHQ-4","volume":"50","author":"K Kroenke","year":"2009","journal-title":"Psychosomatics"},{"issue":"3","key":"pone.0299170.ref024","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"BT Yeo","year":"2011","journal-title":"J Neurophysiol"},{"issue":"2","key":"pone.0299170.ref025","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"B. Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"pone.0299170.ref026","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuroimage.2013.05.099","article-title":"The effect of scan length on the reliability of resting-state fMRI connectivity estimates","volume":"83","author":"RM Birn","year":"2013","journal-title":"Neuroimage"},{"key":"pone.0299170.ref027","doi-asserted-by":"crossref","first-page":"148081","DOI":"10.1016\/j.brainres.2022.148081","article-title":"Functional connectivity of cortical resting-state networks is differentially affected by rest conditions","volume":"1796","author":"Z Fernandez","year":"2022","journal-title":"Brain Res"},{"issue":"Pt 12","key":"pone.0299170.ref028","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1093\/brain\/awt275","article-title":"Neural network connectivity differences in children who stutter","volume":"136","author":"SE Chang","year":"2013","journal-title":"Brain"},{"issue":"2","key":"pone.0299170.ref029","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neuroimage.2011.08.056","article-title":"AFNI: what a long strange trip it\u2019s been","volume":"62","author":"RW Cox","year":"2012","journal-title":"Neuroimage"},{"issue":"3","key":"pone.0299170.ref030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/mrm.1910340303","article-title":"Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping","volume":"34","author":"SG Kim","year":"1995","journal-title":"Magn Reson Med"},{"issue":"5","key":"pone.0299170.ref031","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/mrm.1910390506","article-title":"Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II)","volume":"39","author":"EC Wong","year":"1998","journal-title":"Magn Reson Med"},{"issue":"9","key":"pone.0299170.ref032","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jpain.2008.04.007","article-title":"Core outcome domains and measures for pediatric acute and chronic\/recurrent pain clinical trials: PedIMMPACT recommendations","volume":"9","author":"PJ McGrath","year":"2008","journal-title":"J Pain"},{"issue":"2","key":"pone.0299170.ref033","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0304-3959(94)90097-3","article-title":"A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales","volume":"56","author":"DD Price","year":"1994","journal-title":"J Pain"},{"issue":"3","key":"pone.0299170.ref034","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.pain.2009.10.004","article-title":"Randomized controlled trials of psychological therapies for management of chronic pain in children and adolescents: an updated meta-analytic review","volume":"148","author":"TM Palermo","year":"2010","journal-title":"J Pain"},{"issue":"14","key":"pone.0299170.ref035","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1523\/JNEUROSCI.5791-10.2011","article-title":"Brain mechanisms supporting the modulation of pain by mindfulness meditation","volume":"31","author":"F Zeidan","year":"2011","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0299170.ref036","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/00000539-200003000-00036","article-title":"The visual analog scale allows effective measurement of preoperative anxiety and detection of patients\u2019 anesthetic concerns","volume":"90","author":"CH Kindler","year":"2000","journal-title":"Anesth Analg"},{"issue":"7","key":"pone.0299170.ref037","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/jpepsy\/jsj062","article-title":"Validation of a symptom provocation test for laboratory studies of abdominal pain and discomfort in children and adolescents","volume":"31","author":"LS Walker","year":"2006","journal-title":"J Pediatr Psychol"},{"issue":"1","key":"pone.0299170.ref038","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"RC Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"issue":"2","key":"pone.0299170.ref039","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01537962","article-title":"A self-report measure of pubertal status: Reliability, validity, and initial norms","volume":"17","author":"AC Petersen","year":"1988","journal-title":"J Youth Adolesc"},{"issue":"4","key":"pone.0299170.ref040","first-page":"227","article-title":"The Generalized Anxiety Disorder 7-item scale in adolescents with generalized anxiety disorder: Signal detection and validation","volume":"29","author":"SA Mossman","year":"2017","journal-title":"Ann Clin Psychiatry"},{"key":"pone.0299170.ref041","first-page":"649","volume-title":"The Anxiety Disorders Interview Schedule for Children for DSM-IV: Clinician manual (child and parent versions)","author":"A Albano","year":"1996"},{"issue":"1","key":"pone.0299170.ref042","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/jpepsy\/16.1.39","article-title":"The functional disability inventory: measuring a neglected dimension of child health status","volume":"16","author":"LS Walker","year":"1991","journal-title":"J Pediatr Psychol"},{"issue":"7","key":"pone.0299170.ref043","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.pain.2011.02.050","article-title":"Clinical utility and validity of the Functional Disability Inventory among a multicenter sample of youth with chronic pain","volume":"152","author":"S Kashikar-Zuck","year":"2011","journal-title":"J Pain"},{"issue":"11","key":"pone.0299170.ref044","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jpain.2010.02.005","article-title":"PROMIS Pediatric Pain Interference Scale: an item response theory analysis of the pediatric pain item bank","volume":"11","author":"JW Varni","year":"2010","journal-title":"J Pain"},{"issue":"4","key":"pone.0299170.ref045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00004583-199704000-00018","article-title":"The Screen for Child Anxiety Related Emotional Disorders (SCARED): Scale construction and psychometric characteristics","volume":"36","author":"B Birmaher","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"pone.0299170.ref046","unstructured":"Mental Health Screening and Assessment Tools for Primary Care. 2010. In: Addressing Mental Health Concerns in Primary Care [Internet]. Am Acad Pediatr."},{"issue":"10","key":"pone.0299170.ref047","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00004583-199910000-00011","article-title":"Psychometric properties of the Screen for Anxiety Related Emotional Disorders (SCARED): A replication study","volume":"38","author":"B Birmaher","year":"1999","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"9","key":"pone.0299170.ref048","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/jpepsy\/jss069","article-title":"The psychometric properties of the Screen for Child Anxiety Related Emotional Disorders in pediatric chronic pain","volume":"37","author":"KEJ Mano","year":"2012","journal-title":"J Pediatr Psychol"},{"key":"pone.0299170.ref049","unstructured":"COVID-19 Exposure and Family Impact Survey (CEFIS). 2020."},{"issue":"1","key":"pone.0299170.ref050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pain.2006.04.026","article-title":"Preliminary validation of a self-efficacy scale for child functioning despite chronic pain (child and parent versions).","volume":"125","author":"B Bursch","year":"2006","journal-title":"J Pain."},{"issue":"3","key":"pone.0299170.ref051","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0304-3959(03)00121-0","article-title":"The child version of the pain catastrophizing scale (PCS-C): a preliminary validation","volume":"104","author":"G Crombez","year":"2003","journal-title":"J Pain"},{"issue":"2","key":"pone.0299170.ref052","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1348\/014466505X29657","article-title":"The short\u2010form version of the Depression Anxiety Stress Scales (DASS\u201021): Construct validity and normative data in a large non\u2010clinical sample","volume":"44","author":"JD Henry","year":"2005","journal-title":"Br J Clin Psychol"},{"issue":"7","key":"pone.0299170.ref053","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.acap.2017.04.161","article-title":"Methods to assess adverse childhood experiences of children and families: toward approaches to promote child well-being in policy and practice","volume":"17","author":"CD Bethell","year":"2017","journal-title":"Acad Pediatr"},{"issue":"9","key":"pone.0299170.ref054","article-title":"Engagement during a Mixed In-Person and Remotely Delivered Psychological Intervention for Youth with Functional Abdominal Pain Disorders and Anxiety","volume":"8","author":"AK Miller","year":"2021","journal-title":"Children (Basel)"},{"issue":"5","key":"pone.0299170.ref055","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jpain.2021.12.001","article-title":"Child-Focused Cognitive Behavioral Therapy for Pediatric Abdominal Pain Disorders Reduces Caregiver Anxiety in Randomized Clinical Trial","volume":"23","author":"AE Kalomiris","year":"2022","journal-title":"J Pain"},{"issue":"1","key":"pone.0299170.ref056","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1207\/S15328007SEM1001_4","article-title":"Adding Missing-Data-Relevant Variables to FIML-Based Structural Equation Models","volume":"10","author":"JW Graham","year":"2003","journal-title":"Struct Equ Modeling"},{"key":"pone.0299170.ref057","volume-title":"Applied Missing Data Analysis","author":"C. Enders","year":"2010"},{"issue":"2","key":"pone.0299170.ref058","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/10705511.2014.882666","article-title":"Modeling Change in the Presence of Non-Randomly Missing Data: Evaluating A Shared Parameter Mixture Model","volume":"21","author":"NC Gottfredson","year":"2014","journal-title":"Struct Equ Modeling"},{"issue":"1","key":"pone.0299170.ref059","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1037\/a0022634","article-title":"Growth modeling with nonignorable dropout: alternative analyses of the STAR*D antidepressant trial","volume":"16","author":"B Muth\u00e9n","year":"2011","journal-title":"Psychol Methods"},{"issue":"2","key":"pone.0299170.ref060","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/10705511.2014.936082","article-title":"Diagnosing global case influence on MAR versus MNAR model comparisons","volume":"22","author":"SK Sterba","year":"2015","journal-title":"Struct Equ Modeling"},{"issue":"2","key":"pone.0299170.ref061","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/hbm.22199","article-title":"The human amygdala and pain: evidence from neuroimaging","volume":"35","author":"LE Simons","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"9","key":"pone.0299170.ref062","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.pain.2014.05.023","article-title":"The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome","volume":"155","author":"LE Simons","year":"2014","journal-title":"J Pain"},{"issue":"3","key":"pone.0299170.ref063","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"RW Cox","year":"1996","journal-title":"Comput Biomed Res"},{"key":"pone.0299170.ref064","unstructured":"MATLAB 9.13.0 (R2022b) ed. Natick, Massachusetts: The MathWorks Inc.; 2022."},{"issue":"6","key":"pone.0299170.ref065","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/head.13814","article-title":"Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents","volume":"60","author":"H Nahman-Averbuch","year":"2020","journal-title":"Headache"},{"issue":"5","key":"pone.0299170.ref066","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/j.pain.0000000000001477","article-title":"Increased pain sensitivity but normal pain modulation in adolescents with migraine","volume":"160","author":"H Nahman-Averbuch","year":"2019","journal-title":"J Pain"},{"issue":"2","key":"pone.0299170.ref067","first-page":"187","article-title":"Recurrent abdominal pain: symptom subtypes based on the Rome II criteria for pediatric functional gastrointestinal disorders","volume":"38","author":"LS Walker","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"pone.0299170.ref068","first-page":"91","article-title":"Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome","volume":"140","author":"K Tillisch","year":"2011","journal-title":"J Gastroenterol"},{"issue":"1","key":"pone.0299170.ref069","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/nmo.12695","article-title":"Excessive coupling of the salience network with intrinsic neurocognitive brain networks during rectal distension in adolescents with irritable bowel syndrome: a preliminary report","volume":"28","author":"X Liu","year":"2016","journal-title":"Neurogastroenterol Motil"},{"issue":"6","key":"pone.0299170.ref070","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0022-3476(98)70400-7","article-title":"Recurrent abdominal pain: A potential precursor of irritable bowel syndrome in adolescents and young adults","volume":"132","author":"LS Walker","year":"1998","journal-title":"J Pediatr"},{"issue":"5","key":"pone.0299170.ref071","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1651-2227.2007.00291.x","article-title":"The impact of recurrent abdominal pain: predictors of outcome in a large population cohort","volume":"96","author":"PG Ramchandani","year":"2007","journal-title":"Acta Paediatr"},{"issue":"1","key":"pone.0299170.ref072","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pain.2007.10.032","article-title":"The frequency, trajectories and predictors of adolescent recurrent pain: A population-based approach","volume":"138","author":"EA Stanford","year":"2008","journal-title":"J Pain"},{"issue":"1","key":"pone.0299170.ref073","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/j.pain.0000000000002297","article-title":"Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis","volume":"163","author":"E Fisher","year":"2022","journal-title":"J Pain"},{"issue":"5","key":"pone.0299170.ref074","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/MPG.0b013e3181de0639","article-title":"A Million-dollar Work-up for Abdominal Pain: Is It Worth It?","volume":"51","author":"G Dhroove","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"pone.0299170.ref075","volume-title":"Diagnostic and statistical manual of mental disorders","author":"APA","year":"2013","edition":"5"},{"issue":"4","key":"pone.0299170.ref076","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.tins.2023.01.006","article-title":"Alterations in pain during adolescence and puberty","volume":"46","author":"H Nahman-Averbuch","year":"2023","journal-title":"Trends Neurosci"},{"issue":"2","key":"pone.0299170.ref077","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/hbm.22199","article-title":"The human amygdala and pain: evidence from neuroimaging","volume":"35","author":"LE Simons","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"2","key":"pone.0299170.ref078","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00429-014-0957-8","article-title":"Rapid treatment-induced brain changes in pediatric CRPS","volume":"221","author":"N Erpelding","year":"2016","journal-title":"Brain Struct Funct"},{"issue":"9","key":"pone.0299170.ref079","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jpain.2014.06.002","article-title":"The Economic Costs of Chronic Pain Among a Cohort of Treatment-Seeking Adolescents in the United States","volume":"15","author":"CB Groenewald","year":"2014","journal-title":"J Pain"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0299170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T13:50:08Z","timestamp":1710769808000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0299170"}},"subtitle":[],"editor":[{"given":"Vanessa","family":"Carels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,18]]},"references-count":79,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0299170","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.08.24302498","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,18]]}}}