{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:22:20Z","timestamp":1791922940021,"version":"4.3.4"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    A 90-day study was conducted to investigate the effects of substituting sunflower oil (SFO) for fish oil (FO) on various parameters in\n                    <jats:italic>Labeo rohita<\/jats:italic>\n                    (initial weight 18.21 \u00b1 0.22 g). Five experimental diets with different levels of SFO (up to 7%) substitution for FO (0%, 25%, 50%, 75%, and 100%) were formulated, ensuring equal levels of nitrogen and lipids. The results indicated that even with 100% substitution of SFO with FO, there were no significant differences (P&gt;0.05) were observed in growth performance. The survival rate (SR), hepato-somatic index (HSI), and viscero-somatic index (VSI) as well as whole-body composition were also nonsignificant by SFO substitution. However, the fatty acid profiles in both muscle and liver were influenced (P&lt;0.05) by dietary substitution. Saturated fats (SFA) decreased, while monounsaturated fats (MUFA), and linoleic acid (LA) increased (P&lt;0.05). On the other hand, the contribution of linolenic acid (ALA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) decreased (P&lt;0.05) as the amount of SFO in the diet increased. Hematology parameters, including red blood cells (RBCs), hemoglobin (Hb), and hematocrit (Hct), were not affected. Globulin (GLO) levels decreased significantly (P&lt;0.05), while alanine transaminase (ALT) and aspartate transaminase (AST) activity showed nonsignificant increases (P&gt;0.05). Total protein (TP) increased (P&lt;0.05) at 100% SFO inclusion in the diet, and albumin (ALB) levels increased (P&lt;0.05) at 75% and 100% SFO inclusion in the diet. Cholesterol (CHOL), triacylglycerol (TG), and high-density lipids (HDL) were not significantly affected (P&gt;0.05), while low-density lipids (LDL) were significantly increased (P&lt;0.05) compared to the control group. Cortisol (CORT) and glucose (GLU) levels showed nonsignificant (P&gt;0.05) changes. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities in the liver and serum were not significantly (P&gt;0.05) affected, while malondialdehyde (MDA) status was significantly (P&lt;0.05) reduced. In conclusion, the fatty acid profile of the muscle and liver of fish was modified by the diets, and FO can be substituted with SFO up to 100% for\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>rohita<\/jats:italic>\n                    , which is beneficial for growth and immunity while marinating the lipid contents in fish. Our study revealed that fully replacing fish oil with SFO shows promise in fully replacing FO without compromising the growth and overall health status of the fish.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0299195","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T13:44:16Z","timestamp":1710423856000},"page":"e0299195","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility of replacing fish oil with sunflower oil on the growth, body composition, fatty acid profile, antioxidant activity, stress response, and blood biomarkers of Labeo rohita"],"prefix":"10.1371","volume":"19","author":[{"given":"Muhammad","family":"Asghar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahroze","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-6256","authenticated-orcid":true,"given":"Murat","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-6247","authenticated-orcid":true,"given":"Simon John","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"ul Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"pone.0299195.ref001","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aquaculture.2019.05.032","article-title":"Effects of early long-chain n-3HUFA programming on growth, antioxidant response and lipid metabolism of Siberian sturgeon (Acipenser baerii Brandt).","volume":"509","author":"L Luo","year":"2019","journal-title":"Aquaculture"},{"issue":"1","key":"pone.0299195.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.111.000893","article-title":"Omega-3 fatty acids EPA and DHA: health benefits throughout life.","volume":"3","author":"D Swanson","year":"2012","journal-title":"Advances in nutrition."},{"issue":"5","key":"pone.0299195.ref003","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2095.2011.00907.x","article-title":"Effects of dietary 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