{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:34:39Z","timestamp":1788561279393,"version":"build-2803163510"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Sarcopenia frequently and progressively occurs in patients with chronic liver disease. This study aimed to clarify the relationship between vitamin D levels and muscle mass loss. A total of 166 patients with chronic liver disease were enrolled in this study. Skeletal muscle mass index (SMI) was measured by bioelectrical impedance analysis at baseline and after 1 year. The rate of change in SMI from baseline after 1 year was calculated: \u0394SMI (%) = [(1-year SMI \u2212 baseline SMI) \/ baseline SMI] \u00d7 100. Muscle mass loss was defined as \u0394SMI \u2264 \u22122%. The median 25-hydroxyvitamin D was 15.2 (11.2\u201319.3) ng\/mL. The median SMI were 6.8 (5.9\u20137.8) kg\/m<jats:sup>2<\/jats:sup> at baseline and 6.7 (5.9\u20137.6) kg\/m<jats:sup>2<\/jats:sup> after 1 year. The median \u0394SMI was \u22121.23% (\u22122.21% to 1.61%). Multivariate analysis identified low 25-hydroxyvitamin D as an independent factor associated with muscle mass loss. The optimal cut-off value of 25-hydroxyvitamin D to predict muscle mass loss was 12.7 ng\/mL. Muscle mass loss was found in 56.4% v.s. 18.0% of patients with 25-hydroxyvitamin D &lt; 12.7 vs. \u2265 12.7 ng\/mL, respectively (p = 9.01 \u00d7 10<jats:sup>\u22127<\/jats:sup>); with the highest incidence in patients with non-alcoholic fatty liver disease (NAFLD). Specifically, patients with NAFLD and 25-hydroxyvitamin D &lt; 12.7 ng\/mL had a significantly higher incidence of muscle mass loss than those with \u2265 12.7 ng\/mL (p = 1.23 \u00d7 10<jats:sup>\u22123<\/jats:sup>). Low vitamin D levels are associated with muscle mass loss after 1 year in patients with chronic liver disease, especially NAFLD.<\/jats:p>","DOI":"10.1371\/journal.pone.0299313","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T17:27:19Z","timestamp":1711474039000},"page":"e0299313","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low vitamin D levels accelerates muscle mass loss in patients with chronic liver 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