{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:21:27Z","timestamp":1791912087794,"version":"4.3.4"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI101935"],"award-info":[{"award-number":["AI101935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI124346"],"award-info":[{"award-number":["AI124346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI160179"],"award-info":[{"award-number":["AI160179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR056296"],"award-info":[{"award-number":["AR056296"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA253095"],"award-info":[{"award-number":["CA253095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Regulated cell death is a key component of the innate immune response, which provides the first line of defense against infection and homeostatic perturbations. However, cell death can also drive pathogenesis. The most well-defined cell death pathways can be categorized as nonlytic (apoptosis) and lytic (pyroptosis, necroptosis, and PANoptosis). While specific triggers are known to induce each of these cell death pathways, it is unclear whether all cell types express the cell death proteins required to activate these pathways. Here, we assessed the protein expression and compared the responses of immune and non-immune cells of human and mouse origin to canonical pyroptotic (LPS plus ATP), apoptotic (staurosporine), necroptotic (TNF-\u03b1 plus z-VAD), and PANoptotic (influenza A virus infection) stimuli. When compared to fibroblasts, both mouse and human innate immune cells, macrophages, expressed higher levels of cell death proteins and activated cell death effectors more robustly, including caspase-1, gasdermins, caspase-8, and RIPKs, in response to specific stimuli. Our findings highlight the importance of considering the cell type when examining the mechanisms regulating inflammation and cell death. Improved understanding of the cell types that contain the machinery to execute different forms of cell death and their link to innate immune responses is critical to identify new strategies to target these pathways in specific cellular populations for the treatment of infectious diseases, inflammatory disorders, and cancer.<\/jats:p>","DOI":"10.1371\/journal.pone.0299577","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:32:18Z","timestamp":1709040738000},"page":"e0299577","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-6265","authenticated-orcid":true,"given":"Sk Mohiuddin","family":"Choudhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-9128","authenticated-orcid":true,"given":"Rajendra","family":"Karki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-6443","authenticated-orcid":true,"given":"Thirumala-Devi","family":"Kanneganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"4","key":"pone.0299577.ref001","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","article-title":"Intracellular NOD-like receptors in host defense and disease","volume":"27","author":"TD Kanneganti","year":"2007","journal-title":"Immunity"},{"issue":"13","key":"pone.0299577.ref002","first-page":"2448","article-title":"Initiation of innate immune responses by surveillance of homeostasis perturbations","volume":"283","author":"HG Cola\u00e7o","year":"2016","journal-title":"Epub 2016 Apr 30"},{"key":"pone.0299577.ref003","first-page":"54","article-title":"Approaching the asymptote? Evolution and revolution in immunology","volume":"1","author":"C.A. Janeway","year":"1989","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"1","key":"pone.0299577.ref004","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"H Kumar","year":"2011","journal-title":"Int Rev Immunol"},{"issue":"2","key":"pone.0299577.ref005","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"TH Mogensen","year":"2009","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"pone.0299577.ref006","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/imr.12912","article-title":"Intracellular innate immune receptors: Life inside the cell","volume":"297","author":"TD Kanneganti","year":"2020","journal-title":"Immunol 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Li","year":"1997","journal-title":"Cell"},{"key":"pone.0299577.ref010","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1074\/jbc.273.10.5841","article-title":"Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex","volume":"273","author":"G Pan","year":"1998","journal-title":"J Biol Chem"},{"key":"pone.0299577.ref011","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","article-title":"Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes","volume":"114","author":"O Micheau","year":"2003","journal-title":"Cell"},{"key":"pone.0299577.ref012","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).","volume":"10","author":"S Christgen","year":"2020","journal-title":"Front Cell Infect Microbiol."},{"issue":"1","key":"pone.0299577.ref013","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/imr.12296","article-title":"Regulation of inflammasome activation","volume":"265","author":"SM Man","year":"2015","journal-title":"Immunol Rev"},{"issue":"7575","key":"pone.0299577.ref014","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"J Shi","year":"2015","journal-title":"Nature"},{"issue":"16","key":"pone.0299577.ref015","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embj.201694696","article-title":"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death","volume":"35","author":"L Sborgi","year":"2016","journal-title":"EMBO J"},{"issue":"7371","key":"pone.0299577.ref016","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"N Kayagaki","year":"2011","journal-title":"Nature"},{"issue":"12","key":"pone.0299577.ref017","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion","volume":"25","author":"WT He","year":"2015","journal-title":"Cell Res"},{"issue":"28","key":"pone.0299577.ref018","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"RA Aglietti","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0299577.ref019","first-page":"133","article-title":"Apoptosis: the biochemistry and molecular biology of programmed cell death","volume":"14","author":"RA Schwartzman","year":"1993","journal-title":"Endocr 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Zhao","year":"2017","journal-title":"Cell Rep"},{"issue":"14","key":"pone.0299577.ref026","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1073\/pnas.1200012109","article-title":"Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis","volume":"109","author":"J Zhao","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"pone.0299577.ref027","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"L Sun","year":"2012","journal-title":"Cell"},{"issue":"7","key":"pone.0299577.ref028","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2008.10.044","article-title":"Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway","volume":"135","author":"J Hitomi","year":"2008","journal-title":"Cell"},{"key":"pone.0299577.ref029","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-052016-100247","article-title":"Necroptosis: Mechanisms and relevance to disease.","volume":"12","author":"L Galluzzi","year":"2017","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"pone.0299577.ref030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: a regulated inflammatory mode of cell death","volume":"15","author":"YK Dhuriya","year":"2018","journal-title":"J Neuroinflammation"},{"issue":"2","key":"pone.0299577.ref031","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"A Degterev","year":"2005","journal-title":"Nat Chem 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Med"},{"issue":"9","key":"pone.0299577.ref038","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","article-title":"PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality","volume":"209","author":"N Pandian","year":"2022","journal-title":"J Immunol"},{"key":"pone.0299577.ref039","first-page":"11","article-title":"It\u2019s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and","author":"JM Gullett","year":"2022","journal-title":"Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects. Cells"},{"key":"pone.0299577.ref040","doi-asserted-by":"crossref","first-page":"e2250235","DOI":"10.1002\/eji.202250235","article-title":"Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease","author":"W Chen","year":"2023","journal-title":"Eur J Immunol"},{"issue":"10","key":"pone.0299577.ref041","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00018-022-04564-z","article-title":"Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method","volume":"79","author":"Y Wang","year":"2022","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"pone.0299577.ref042","doi-asserted-by":"crossref","first-page":"zcac033","DOI":"10.1093\/narcan\/zcac033","article-title":"Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology","volume":"4","author":"R Mall","year":"2022","journal-title":"NAR Cancer"},{"issue":"12","key":"pone.0299577.ref043","doi-asserted-by":"crossref","first-page":"789","DOI":"10.4049\/immunohorizons.2000097","article-title":"RIPK1 distinctly regulates Yersinia-induced inflammatory dell death, PANoptosis.","volume":"4","author":"RKS Malireddi","year":"2020","journal-title":"Immunohorizons.PubMed Central PMCID"},{"issue":"7876","key":"pone.0299577.ref044","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"S Lee","year":"2021","journal-title":"Nature"},{"issue":"3","key":"pone.0299577.ref045","doi-asserted-by":"crossref","first-page":"109858","DOI":"10.1016\/j.celrep.2021.109858","article-title":"ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis","volume":"37","author":"R Karki","year":"2021","journal-title":"Cell 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(PANoptosis).","volume":"295","author":"B Banoth","year":"2020","journal-title":"J Biol Chem"},{"issue":"13","key":"pone.0299577.ref049","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.cell.2023.05.005","article-title":"NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs","volume":"186","author":"B Sundaram","year":"2023","journal-title":"Cell"},{"issue":"11","key":"pone.0299577.ref050","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1073\/pnas.100133697","article-title":"A DNA transfection system for generation of influenza A virus from eight plasmids","volume":"97","author":"E Hoffmann","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"pone.0299577.ref051","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1038\/s41596-020-0374-9","article-title":"A comprehensive guide to studying inflammasome activation and cell death","volume":"15","author":"RE Tweedell","year":"2020","journal-title":"Nat Protoc"},{"issue":"3","key":"pone.0299577.ref052","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF01121789","article-title":"Decreased protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes.","volume":"12","author":"V Sanchez","year":"1992","journal-title":"Biosci Rep"},{"issue":"9","key":"pone.0299577.ref053","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41419-021-04014-x","article-title":"The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells","volume":"12","author":"S Hannes","year":"2021","journal-title":"Cell Death Dis"},{"issue":"5","key":"pone.0299577.ref054","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"D Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"pone.0299577.ref055","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","article-title":"Regulated cell death (RCD) in cancer: key pathways and targeted therapies.","volume":"7","author":"F Peng","year":"2022","journal-title":"Signal Transduct Target Ther."},{"key":"pone.0299577.ref056","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1016\/j.csbj.2021.07.038","article-title":"From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways","volume":"19","author":"Y Wang","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"issue":"8","key":"pone.0299577.ref057","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/s41418-022-00938-9","article-title":"Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3\/MLKL to prevent lymphopenia","volume":"29","author":"X Li","year":"2022","journal-title":"Cell Death Differ"},{"key":"pone.0299577.ref058","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"C Rogers","year":"2017","journal-title":"Nat Commun"},{"issue":"7661","key":"pone.0299577.ref059","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Y Wang","year":"2017","journal-title":"Nature"},{"issue":"2","key":"pone.0299577.ref060","doi-asserted-by":"crossref","first-page":"e3002022","DOI":"10.1371\/journal.pbio.3002022","article-title":"Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications","volume":"21","author":"RE Tweedell","year":"2023","journal-title":"PLoS Biol"},{"issue":"2","key":"pone.0299577.ref061","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41590-021-01091-0","article-title":"Innate immunity: the first line of defense against SARS-CoV-2","volume":"23","author":"MS Diamond","year":"2022","journal-title":"Nat Immunol"},{"key":"pone.0299577.ref062","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coisb.2019.10.011","article-title":"Stimulus-specificity in the responses of immune sentinel cells","volume":"18","author":"K Sheu","year":"2019","journal-title":"Curr Opin Syst Biol"},{"issue":"5396","key":"pone.0299577.ref063","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"A 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