{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:13:16Z","timestamp":1789035196801,"version":"build-2803163510"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tokyo Human Resource Fund for the City Diplomacy Scholar"},{"name":"MEXT Grant-in-Aid for Scientific Research","award":["21K11502"],"award-info":[{"award-number":["21K11502"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In infants, spontaneous movement towards the midline (MTM) indicates the initiation of anti-gravity ability development. Markerless 2D pose estimation is a cost-effective, time-efficient, and quantifiable alternative to movement assessment. We aimed to establish correlations between pose estimation features and MTM in early-age infants. Ninety-four infant videos were analysed to calculate the percentage and rate of MTM occurrence. 2D Pose estimation processed the videos and determined the distances and areas using wrist and ankle landmark coordinates. We collected data using video recordings from 20 infants aged 8\u201316 weeks post-term age. Correlations between MTM observations and distance values were evaluated. Differences in areas between groups of videos showing MTM and no MTM in the total, lower-limb, and upper-limb categories were examined. MTM observations revealed common occurrences of hand-to-trunk and foot-to-foot movements. Weak correlations were noted between limb distances to the midbody imaginary line and MTM occurrence values. Lower MTM showed significant differences in the lower part (p = 0.003) and whole area (p = 0.001). Video recording by parents or guardians could extract features using 2D pose estimation, assisting in the early identification of MTM in infants. Further research is required to assess a larger sample size with the diversity of MTM motor behaviour, and later developmental skills, and collect data from at-risk infants.<\/jats:p>","DOI":"10.1371\/journal.pone.0299758","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T18:32:26Z","timestamp":1709145146000},"page":"e0299758","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between pose estimation features regarding movements towards the midline in early 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AHS."},{"key":"pone.0299758.ref027","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1109\/TPAMI.2019.2929257","article-title":"OpenPose: Realtime multi-person 2D pose estimation using part affinity fields","volume":"43","author":"Z Cao","year":"2021","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"pone.0299758.ref028","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-981-10-5122-7_50","volume-title":"EMBEC & NBC 2017.","author":"N Hesse","year":"2018"},{"key":"pone.0299758.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-89347-5","article-title":"Novel AI driven approach to classify infant motor functions.","volume":"11","author":"S Reich","year":"2021","journal-title":"Sci Rep."},{"key":"pone.0299758.ref030","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fneur.2014.00284","article-title":"Movement recognition technology as a method of assessing spontaneous general movements in high risk 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