{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:39:01Z","timestamp":1792093141148,"version":"4.4.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2021-01823"],"award-info":[{"award-number":["2021-01823"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Care transitions following a stroke call for integrated care approaches to reduce death and disability. The proposed research described in this study protocol aims to evaluate the effectiveness of a person-centred multicomponent care transition support and the process in terms of contextual moderators, implementation aspects and mechanisms of impact.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A non-randomized controlled trial design will be used. The intervention includes person-centred dialogue intended to permeate all patient-provider communication, various pedagogical modes of information, a person-centred care and rehabilitation plan, and a bridging e-meeting to prepare patients for homecoming. Patients with stroke or TIA who are to be discharged from the participating hospitals to home and referred to a neurorehabilitation team for continued rehabilitation will be included. Follow-ups will be conducted at one week, 3 months and 12 months. Data will be collected on the primary outcome of perceived quality of the care transition, and on the secondary outcomes of health literacy, medication adherence, and perceived person-centeredness. Data for process evaluation will be collected through semi-structured interviews, focus groups, participatory observations, and the Normalisation Measure Development Questionnaire.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>The study will provide insights on implementation, mechanisms of impact, contextual moderators, and effectiveness of a care transition support, targeting a poorly functioning part of the care trajectory for people with stroke and TIA.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Clinical trial registration<\/jats:title>\n<jats:p>ClinicalTrials.gov Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05646589\" xlink:type=\"simple\">NCT05646589<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0299800","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T17:27:45Z","timestamp":1710437265000},"page":"e0299800","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["A person-centred care transition support for people with stroke\/TIA: A study protocol for effect and process evaluation using a non-randomised controlled design"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-7615","authenticated-orcid":true,"given":"Sebastian","family":"Lindblom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Flink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"von Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Tistad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Una","family":"Stenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Elf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel C.","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Charlotte","family":"Laska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-8887","authenticated-orcid":true,"given":"Charlotte","family":"Ytterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"issue":"1","key":"pone.0299800.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.05.021","article-title":"Navigating the poststroke continuum of care","volume":"22","author":"J Wissel","year":"2013","journal-title":"Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association"},{"issue":"4","key":"pone.0299800.ref002","first-page":"Cd000197","article-title":"Organised inpatient (stroke unit) care for stroke: network meta-analysis","volume":"4","author":"P Langhorne","year":"2020","journal-title":"The Cochrane database of systematic reviews"},{"key":"pone.0299800.ref003","unstructured":"OECD. 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Samordnad v\u00e5rd och omsorg. En analys av samordningsutmaningar i ett fragmenterat v\u00e5rd- och omsorgssystem2016."},{"issue":"6","key":"pone.0299800.ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5334\/ijic.3003","article-title":"Planning for the Discharge, not for Patient Self-Management at Home\u2014An Observational and Interview Study of Hospital Discharge","volume":"17","author":"M Flink","year":"2017","journal-title":"International journal of integrated care"},{"issue":"16","key":"pone.0299800.ref011","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3109\/09638288.2012.740134","article-title":"Client and carer experience of transition home from inpatient stroke rehabilitation","volume":"35","author":"L Gustafsson","year":"2013","journal-title":"Disability and rehabilitation"},{"issue":"18","key":"pone.0299800.ref012","first-page":"1715","article-title":"Quality of discharge practices and patient understanding at an academic medical center","volume":"173","author":"LI Horwitz","year":"2013","journal-title":"JAMA internal medicine"},{"issue":"11","key":"pone.0299800.ref013","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s11606-012-2168-4","article-title":"Medication reconciliation accuracy and patient understanding of intended medication changes on hospital discharge","volume":"27","author":"B Ziaeian","year":"2012","journal-title":"Journal of general internal medicine"},{"key":"pone.0299800.ref014","unstructured":"Riks-Stroke. Riks-Stroke: \u00e5rsrapport 2018 Ume\u00e5: Riks-Stroke; 2019 [cited 2020 September 8]. Available from: http:\/\/www.riksstroke.org\/wp-content\/uploads\/2019\/09\/Riksstroke_A%CC%8Arsrapport-2018_slutversionWEB.pdf."},{"issue":"1","key":"pone.0299800.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15324796ABM2601_01","article-title":"Self-management education: history, definition, outcomes, and mechanisms","volume":"26","author":"KR Lorig","year":"2003","journal-title":"Annals of behavioral medicine: a publication of the Society of Behavioral Medicine"},{"key":"pone.0299800.ref016","unstructured":"National person-centred and cohesive care process for stroke and TIA. 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