{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:50:21Z","timestamp":1793155821820,"version":"4.5.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sheikh kalifa Medical city, Ajman","id":[{"id":"https:\/\/ror.org\/03xhv9997","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Worldwide vitamin D insufficiency is remarkably prevalent in both children and adults, including pregnant women. The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25(OH)D3 and ergocalciferol 25(OH)D2. There is a known correlation between maternal and umbilical cord blood (UCB) 25(OH)D; however, whether specific maternal demographics or comorbidities influence the correlation remains uncertain. This prospective observational study was designed to study if maternal 25(OH)D levels, maternal age and BMI, amount of supplementation, mode of delivery, diabetes, hypertension\/preeclampsia, or sunlight exposure had an impact on the correlation. Women were enrolled in the study at admission to the labor ward. If they agreed to participate, venous blood was directly collected and analyzed for 25(OH)D. The UCB was sampled after delivery from the unclamped cord and immediately analyzed for 25(OH)D. ANOVA, Fisher\u2019s exact test, Pearson\u2019s correlation, and test of the differences between correlations using Fisher\u2019s z-transformation with Bonferroni correction were used accordingly. Of the 298 women enrolled, blood from both the mother and umbilical cord was analyzed successfully for 25(OH)D in 235 cases. The crude correlation between maternal and UCB 25(OH)D was very strong over all values of 25(OH)D (r = 0.905, R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.821,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0,001) and remained strong independently of maternal demographics or co-morbidities (r \u2265 0.803, R\n                    <jats:sup>2<\/jats:sup>\n                    \u2265 0.644,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001). For women who delivered by caesarean section in second stage the correlation was strong (r \u2265 0.633, R\n                    <jats:sup>2<\/jats:sup>\n                    \u2265 0.4,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.037). Test of differences between correlations showed significant stronger correlation in women with unknown 25(OH)D3 supplementation compared to women receiving 10.000 IU\/week (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02) and 20.000IU\/week (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01) and that the correlation was significantly stronger for women with a BMI of 25\u201329.9 compared to women with a BMI of &lt;24.9 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.004) and 30\u201334.9 (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). 213 (91%) women had lower 25(OH)D compared to the neonate, with a mean difference of -13.7nmol\/L (SD = 15.6). In summary, the correlation between maternal and UCB 25(OH)D is very strong throughout low to high maternal levels of 25(OH)D with lower levels in maternal blood. Typical maternal demographics and comorbidities did not affect the transition.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0299862","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T13:33:05Z","timestamp":1713879185000},"page":"e0299862","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Correlation between maternal and umbilical cord 25-hydroxy-vitamin D levels over a range of values. A prospective observational study from the United Arab Emirates"],"prefix":"10.1371","volume":"19","author":[{"given":"Magnus","family":"Jutell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakura","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lindstrom","family":"Bagge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Erik","family":"Isberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9032-5428","authenticated-orcid":true,"given":"Nana","family":"Wiberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"5","key":"pone.0299862.ref001","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/10408398.2016.1220915","article-title":"Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review","volume":"58","author":"S. Agarwal","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"7","key":"pone.0299862.ref002","first-page":"2097","article-title":"Immunologic Effects of Vitamin D on Human Health and Disease","volume":"12","author":"N. Charoenngam","year":"2020","journal-title":"Nutr. 2020"},{"issue":"10","key":"pone.0299862.ref003","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.4049\/jimmunol.1003332","article-title":"Vitamin D and the regulation of placental inflammation","volume":"186","author":"N. Q. Liu","year":"2011","journal-title":"J. Immunol."},{"issue":"1","key":"pone.0299862.ref004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/cclm-2016-0264","article-title":"Assessment of Vitamin D status\u2014A changing landscape","volume":"55","author":"M. Herrmann","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"pone.0299862.ref005","doi-asserted-by":"crossref","article-title":"The interrelationship of serum 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in pregnancy at term: a meta-analysis","author":"P. D. Papapetrou","DOI":"10.14310\/horm.2002.1263"},{"key":"pone.0299862.ref006","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71094","article-title":"\u201cPlacental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit,\u201d","volume":"11","author":"B. Ashley","year":"2022","journal-title":"Elife"},{"issue":"8","key":"pone.0299862.ref007","doi-asserted-by":"crossref","first-page":"e3403","DOI":"10.1210\/clinem\/dgac263","article-title":"Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D","volume":"107","author":"R. J. Moon","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"pone.0299862.ref008","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3945\/ajcn.112.035683","article-title":"Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations.","volume":"96","author":"B. Novakovic","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"issue":"8142","key":"pone.0299862.ref009","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0140-6736(79)91612-X","article-title":"Plasma 25-hydroxyvitamin D in pregnant Asian women and their babies.","volume":"2","author":"J. Z. Heckmatt","year":"1979","journal-title":"Lancet (London, England)"},{"issue":"681","key":"pone.0299862.ref010","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/pgmj.58.681.408","article-title":"Transplacental transfer of 25-hydroxy-cholecalciferol.","volume":"58","author":"M. M. Gupta","year":"1982","journal-title":"Postgrad. Med. 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Vivanti","year":"2020"},{"issue":"10","key":"pone.0299862.ref014","article-title":"Regimens of vitamin D supplementation for women during pregnancy","volume":"2019","author":"C. Palacios","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"issue":"11","key":"pone.0299862.ref015","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: an update on the current status worldwide","volume":"74","author":"K. Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"issue":"Suppl. 2","key":"pone.0299862.ref016","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000508421","article-title":"Vitamin D in Preterm and Full-Term Infants","volume":"76","author":"S. A. Abrams","year":"2020","journal-title":"Ann. Nutr. 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Steril."},{"issue":"3","key":"pone.0299862.ref020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency.","volume":"357","author":"M. F. Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"pone.0299862.ref021","doi-asserted-by":"crossref","DOI":"10.3390\/nu10030294","article-title":"Systematic review of vitamin D and hypertensive disorders of pregnancy","volume":"10","author":"K. M. O\u2019Callaghan","year":"2018","journal-title":"Nutrients"},{"issue":"2","key":"pone.0299862.ref022","doi-asserted-by":"crossref","first-page":"e0281234","DOI":"10.1371\/journal.pone.0281234","article-title":"Maternal serum vitamin D level in early pregnancy and risk for preeclampsia: A case-control study in Southern Sweden.","volume":"18","author":"G. 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Steroid Biochem. Mol. Biol."},{"issue":"12","key":"pone.0299862.ref037","doi-asserted-by":"crossref","DOI":"10.3390\/nu11123034","article-title":"Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study.","volume":"11","author":"G. Muscogiuri","year":"2019","journal-title":"Nutrients"},{"issue":"5","key":"pone.0299862.ref038","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1210\/jcem-61-5-969","article-title":"Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels.","volume":"61","author":"D. D. Bikle","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"pone.0299862.ref039","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1210\/jcem-63-4-954","article-title":"Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.","volume":"63","author":"D. D. 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Metab."},{"issue":"2","key":"pone.0299862.ref043","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23037","article-title":"The pre-analytical stability of 25-hydroxyvitamin D: Storage and mixing effects","volume":"34","author":"A. Borai","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"pone.0299862.ref044","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.annepidem.2007.12.001","article-title":"Vitamin D Status: Measurement, Interpretation, and Clinical Application","volume":"19","author":"M. F. Holick","year":"2009","journal-title":"Ann Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0299862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T13:47:03Z","timestamp":1713880023000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0299862"}},"subtitle":[],"editor":[{"given":"Sanjoy Kumer","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0299862","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}