{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:08:29Z","timestamp":1785820109604,"version":"3.56.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK091538,"],"award-info":[{"award-number":["DK091538,"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK098203"],"award-info":[{"award-number":["DK098203"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG069781"],"award-info":[{"award-number":["AG069781"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK007203"],"award-info":[{"award-number":["DK007203"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG013319"],"award-info":[{"award-number":["AG013319"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG044271"],"award-info":[{"award-number":["AG044271"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Fatty acid esters of hydroxy fatty acid (FAHFA) are anti-diabetic and anti-inflammatory lipokines. Recently FAHFAs were also found to predict cardiorespiratory fitness in a cross-sectional study of recreationally trained runners. Here we report the influences of body composition and gender on static FAHFA abundances in circulation. We compared the association between circulating FAHFA concentrations and body composition, determined by dual x-ray absorptiometry, in female recreational runners who were lean (BMI &lt; 25 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , n = 6), to those who were overweight (BMI \u2265 25 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , n = 7). To characterize the effect of gender we also compared circulating FAHFAs in lean male recreational runners (n = 8) to recreationally trained lean female (n = 6) runner group. Circulating FAHFAs were increased in females in a manner that was modulated by specific adipose depot sizes, blood glucose, and lean body mass. As expected, circulating FAHFAs were diminished in the overweight group, but strikingly, within the lean cohort, increases in circulating FAHFAs were promoted by increased fat mass, relative to lean mass, while the overweight group showed a significantly attenuated relationship. These studies suggest multimodal regulation of circulating FAHFAs and raise hypotheses to test endogenous FAHFA dynamic sources and sinks in health and disease, which will be essential for therapeutic target development. Baseline circulating FAHFA concentrations could signal sub-clinical metabolic dysfunction in metabolically healthy obesity.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0300037","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T13:45:31Z","timestamp":1715003131000},"page":"e0300037","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gender-based heterogeneity of FAHFAs in trained runners"],"prefix":"10.1371","volume":"19","author":[{"given":"Alisa B.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Dengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis C.","family":"Hughey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-2413","authenticated-orcid":true,"given":"Xianlin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Puchalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-4426","authenticated-orcid":true,"given":"Peter A.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"pone.0300037.ref001","article-title":"ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids","author":"R Patel","year":"2022","journal-title":"Nature"},{"issue":"10","key":"pone.0300037.ref002","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1172\/JCI127092","article-title":"PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms","volume":"129","author":"P Zhou","year":"2019","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"pone.0300037.ref003","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cmet.2018.01.001","article-title":"Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis","volume":"27","author":"I Syed","year":"2018","journal-title":"Cell Metab"},{"issue":"2","key":"pone.0300037.ref004","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2014.09.035","article-title":"Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects","volume":"159","author":"MM Yore","year":"2014","journal-title":"Cell"},{"issue":"22","key":"pone.0300037.ref005","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMra2216691","article-title":"Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes.","volume":"388","author":"A Santoro","year":"2023","journal-title":"New England Journal of Medicine."},{"key":"pone.0300037.ref006","doi-asserted-by":"crossref","first-page":"100108","DOI":"10.1016\/j.jlr.2021.100108","article-title":"Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs).","volume":"62","author":"P Aryal","year":"2021","journal-title":"J Lipid Res"},{"issue":"22","key":"pone.0300037.ref007","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/jacs.9b00045","article-title":"Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation","volume":"141","author":"D Tan","year":"2019","journal-title":"J Am Chem Soc"},{"key":"pone.0300037.ref008","first-page":"1061","article-title":"Highly sensitive determination of fatty acid esters of hydroxyl fatty acids by liquid chromatography-mass spectrometry","author":"QF Zhu","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"pone.0300037.ref009","article-title":"Acute aerobic exercise reveals FAHFAs distinguish the metabolomes of overweight and normal weight runners.","author":"AB Nelson","year":"2022","journal-title":"JCI Insight."},{"issue":"1","key":"pone.0300037.ref010","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MOL.0b013e3283346ccc","article-title":"The distinction of metabolically \u2019healthy\u2019 from \u2019unhealthy\u2019 obese individuals","volume":"21","author":"M. 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