{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:45:15Z","timestamp":1792118715927,"version":"4.4.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304330\/2020-5"],"award-info":[{"award-number":["304330\/2020-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306577\/2020-8"],"award-info":[{"award-number":["306577\/2020-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310491\/2021"],"award-info":[{"award-number":["310491\/2021"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["314668\/2020-9"],"award-info":[{"award-number":["314668\/2020-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Photobiomodulation is a safe option for controlling pain, edema, and trismus when applied postoperatively in third molar surgery. However, administration prior to surgery has been under-explored. This study aims to explore the effectiveness of pre-emptive photobiomodulation in reducing postoperative edema in impacted lower third molar extractions. Two groups of healthy individuals undergoing tooth extraction will be randomly assigned: Control group receiving pre-emptive corticosteroid and simulated photobiomodulation, and Photobiomodulation Group receiving intraoral low-intensity laser and extraoral LED cluster application. The primary outcome will be postoperative edema after 48 h. The secondary outcomes will be pain, trismus dysphagia, and analgesic intake (paracetamol). These outcomes will be assessed at baseline as well as two and seven days after surgery. Adverse effects will be recorded. Data will be presented as means \u00b1 SD and a p-value &lt; 0.05 will be indicative of statistical significance.<\/jats:p>","DOI":"10.1371\/journal.pone.0300136","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:57:22Z","timestamp":1718647042000},"page":"e0300136","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of the pre-emptive effect of photobiomodulation in the postoperative period of impacted lower third molar extractions: A randomized, controlled, double-blind study protocol"],"prefix":"10.1371","volume":"19","author":[{"given":"Daniel Rodr\u00edguez","family":"Salaberry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-5186","authenticated-orcid":true,"given":"Laura Hermida","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf Wilhem Consolandich","family":"Cirisola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Larcher","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Chavantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Scarparo","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Let\u00edcia Leal","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Taboada","family":"Sobral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9055-1524","authenticated-orcid":true,"given":"Cinthya Cosme Gutierrez","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Jansiski","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Kalil","family":"Bussadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina Ratto Tempestini","family":"Horliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Agnelli","family":"Mesquita Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-9286","authenticated-orcid":true,"given":"Kristianne Porta Santos","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"issue":"5","key":"pone.0300136.ref001","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.oooo.2021.03.004","article-title":"Third molar surgery: Past, present, and the future.","volume":"132","author":"JS Sifuentes-Cervantes","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"issue":"2","key":"pone.0300136.ref002","first-page":"70","article-title":"Comparative Efficacy of Amoxicillin\/Clavulanic Acid and Levofloxacin in the Reduction of Postsurgical Sequelae After Third Molar Surgery: A Randomized, Double-Blind, Clinical Trial in a Nigerian University Teaching Hospital.","volume":"22","author":"KC Ndukwe","year":"2016"},{"issue":"3","key":"pone.0300136.ref003","first-page":"530","volume":"11","author":"OD Osunde","year":"2011","journal-title":"Management of inflammatory complications in third molar surgery: a review of the literature. Afr Health Sci"},{"issue":"6","key":"pone.0300136.ref004","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bjoms.2020.09.020","article-title":"Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review","volume":"59","author":"T Milic","year":"2021","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"2","key":"pone.0300136.ref005","first-page":"53","article-title":"Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data.","volume":"8","author":"G Cervino","year":"2019","journal-title":"Antibiotics (Basel).May 2"},{"issue":"4","key":"pone.0300136.ref006","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1007\/s12070-023-03883-2","article-title":"Role of Prophylactic Dose of Oral Amoxicillin Trihydrate in Prevention of Bacteremia Post Surgical Removal of Impacted Mandibular Third Molar: A Clinical Study.","volume":"75","author":"VD Sane","year":"2023","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"issue":"1","key":"pone.0300136.ref007","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijom.2023.08.001","article-title":"Antibiotic prophylaxis in the prevention of dry socket and surgical site infection after lower third molar extraction: a network meta-analysis.","volume":"53","author":"O Camps-Font","year":"2024","journal-title":"Int J Oral Maxillofac Surg."},{"issue":"7","key":"pone.0300136.ref008","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s12325-016-0357-y","article-title":"Do Corticosteroids Still Have a Role in the Management of Third Molar Surgery?","volume":"33","author":"WC Ngeow","year":"2016","journal-title":"Adv Ther."},{"issue":"3","key":"pone.0300136.ref009","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2344\/anpr-64-05-08","article-title":"Preemptive Effect of Dexamethasone in Third-Molar Surgery: A Meta-Analysis.","volume":"64","author":"SGM Falci","year":"2017","journal-title":"Anesth Prog"},{"issue":"2","key":"pone.0300136.ref010","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5037\/jomr.2018.9201","article-title":"Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review.","volume":"9","author":"MK Larsen","year":"2018","journal-title":"J Oral Maxillofac Res"},{"key":"pone.0300136.ref011","doi-asserted-by":"crossref","first-page":"e2780","DOI":"10.6061\/clinics\/2021\/e2780","article-title":"Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials.","volume":"76","author":"PUJ Silva","year":"2021","journal-title":"Clinics (Sao Paulo)."},{"issue":"6","key":"pone.0300136.ref012","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ijom.2018.09.005","article-title":"Does methylprednisolone improve postoperative outcomes after mandibular third molar surgery? A systematic review and meta-analysis.","volume":"48","author":"SA Nagori","year":"2019","journal-title":"Int J Oral Maxillofac Surg."},{"issue":"1","key":"pone.0300136.ref013","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijom.2018.05.023","article-title":"Efficacy of corticosteroids versus placebo in impacted third molar surgery: systematic review and meta-analysis of randomized controlled trials.","volume":"48","author":"RAC Almeida","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"pone.0300136.ref014","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5005\/jp-journals-10024-2852","article-title":"Assessment of C-reactive Protein Level and Efficacy of Diclofenac Sodium and Mefenamic Acid in Relieving Pain in Mandibular Impacted Third Molar Surgery.","volume":"22","author":"R Singh","year":"2021","journal-title":"J Contemp Dent Pract"},{"issue":"1","key":"pone.0300136.ref015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","article-title":"Therapeutic Mechanisms of Glucocorticoids","volume":"29","author":"J Vandewalle","year":"2018","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"pone.0300136.ref016","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1089\/pho.2013.3510","article-title":"Is it time to consider photobiomodulation as a drug equivalent?","volume":"31","author":"T. Karu","year":"2013","journal-title":"Photomed Laser Surg."},{"issue":"2","key":"pone.0300136.ref017","doi-asserted-by":"crossref","first-page":"313.e1","DOI":"10.1016\/j.joms.2020.09.018","article-title":"The Use of Low-Level Laser Therapy to Reduce Postoperative Morbidity After Third Molar Surgery: A Systematic Review and Meta-Analysis.","volume":"79","author":"F Domah","year":"2021","journal-title":"J Oral Maxillofac Surg"},{"issue":"11","key":"pone.0300136.ref018","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jcms.2021.06.006","article-title":"Brasil GMLC, Ara\u00fajo Soares GP, Fernandes Paiva DF, deUse of low-level laser therapy to reduce postoperative pain, edema, and trismus following third molar surgery: A systematic review and meta-analysis.","volume":"49","author":"FJ Duarte de Oliveira","year":"2021","journal-title":"Assis de Souza J\u00fanior F.J Craniomaxillofac Surg."},{"issue":"4","key":"pone.0300136.ref019","first-page":"e467","article-title":"Effect of pre-operatory low-level laser therapy on pain, swelling, and trismus associated with third-molar surgery.","volume":"22","author":"M Petrini","year":"2017","journal-title":"Med Oral Patol Oral Cir Bucal."},{"key":"pone.0300136.ref020","unstructured":"Mello ES. Preparation of orofacial tissues involved in surgeries for impacted lower third molars with infrared LED for pain, trismus, and edema control: A clinical trial, randomized, double-blind, controlled study. M.Sc. Dissertation. Nove de Julho University, 2021. 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