{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:48:00Z","timestamp":1782730080421,"version":"3.54.5"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To assess the association between vitreous hyper-reflective dots (VHD) and the macular thickness changes following uneventful phacoemulsification.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this prospective cohort study optical coherence tomography (OCT) examinations were performed preoperatively and 1 week, 1 month and 3 months postoperatively in patients undergoing cataract surgery. OCT images were analyzed for retinal central subfield thickness (CST) and preretinal VHDs. Surgeries were recorded for the assessment of lens fragments in the space of Berger.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>111 eyes of 97 patient were enrolled of whom 69 (62.2%) were female. VHDs were seen in 25 eyes (22.5%) at week 1; in 21 eyes (18.9%) at month 1 and in 3 eyes (2.7%) at month 3. In all eyes with VHDs retro-capsular lens fragments were visible immediately after phacoemulsification. The number of VHDs significantly decreased over the postoperative period. There was a moderate correlation between the number of VHDs and CST at 1 month (r = 0.426, p&lt;0.001). In eyes with VHD the CST averaged 238.8\u00b117.6 \u03bcm (214\u2013266) at 1 week; 276.1\u00b163.5 \u03bcm (231\u2013481) at 1 month and 285.1\u00b1122.3 \u03bcm (227\u2013785) at 3 months. In eyes with no detectable VHDs CST averaged 235.9\u00b123.3 \u03bcm (192\u2013311) at 1 week; 240.1\u00b121.6 \u03bcm (200\u2013288) at 1 month and 242.2\u00b121.3 \u03bcm (205\u2013289) at 3 months. Although the differences among the assessment points were relatively low, there was a significant difference in general (p&lt;0.001, Friedman test).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In conclusion, VHDs seem to cause macular thickening throughout the postoperative course. The origin of VHDs is still unknown; however, they presumably represent lens fragments that provoke subclinical inflammation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0300148","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T18:02:47Z","timestamp":1712685767000},"page":"e0300148","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vitreous hyper-reflective dots and the macular thickness after cataract surgery"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-3140","authenticated-orcid":true,"given":"Jurica","family":"Predovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damir","family":"Bosnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Markovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"\u0106uri\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josipa","family":"Bra\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-6403","authenticated-orcid":true,"given":"Thomas","family":"Georgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-6071","authenticated-orcid":true,"given":"Wolfgang","family":"List","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Glatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-4820","authenticated-orcid":true,"given":"Domagoj","family":"Ivastinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"issue":"3\u20134","key":"pone.0300148.ref001","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1076\/soph.17.3.167.14794","article-title":"Pseudophakic cystoid macular edema","volume":"17","author":"S Ray","year":"2002","journal-title":"Semin Ophthalmol"},{"issue":"1","key":"pone.0300148.ref002","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/ICU.0b013e32834cd5f8","article-title":"Pseudophakic cystoid macular edema","volume":"23","author":"Y Yonekawa","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"issue":"9","key":"pone.0300148.ref003","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.jcrs.2007.05.013","article-title":"Clinical pseudophakic cystoid macular edema. 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