{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:31:44Z","timestamp":1793215904165,"version":"4.5.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001075","name":"Channel 7 Children's Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001075","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Healthy Development Adelaide"},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2009730"],"award-info":[{"award-number":["GNT2009730"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1195716"],"award-info":[{"award-number":["GNT1195716"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Future Fund","award":["PHRDI000014"],"award-info":[{"award-number":["PHRDI000014"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Preconception health provides an opportunity to examine a woman\u2019s health status and address modifiable risk factors that can impact both a woman\u2019s and her child\u2019s health once pregnant. In this review, we aimed to investigate the preconception risk factors and interventions of early pregnancy and its impact on adverse maternal, perinatal and child health outcomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We conducted a scoping review following the PRISMA-ScR guidelines to include relevant literature identified from electronic databases. We included reviews that studied preconception risk factors and interventions among adolescents and young adults, and their impact on maternal, perinatal, and child health outcomes. All identified studies were screened for eligibility, followed by data extraction, and descriptive and thematic analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Findings<\/jats:title>\n<jats:p>We identified a total of 10 reviews. The findings suggest an increase in odds of maternal anaemia and maternal deaths among young mothers (up to 17 years) and low birth weight (LBW), preterm birth, stillbirths, and neonatal and perinatal mortality among babies born to mothers up to 17 years compared to those aged 19\u201325 years in high-income countries. It also suggested an increase in the odds of congenital anomalies among children born to mothers aged 20\u201324 years. Furthermore, cancer treatment during childhood or young adulthood was associated with an increased risk of preterm birth, LBW, and stillbirths. Interventions such as youth-friendly family planning services showed a significant decrease in abortion rates. Micronutrient supplementation contributed to reducing anaemia among adolescent mothers; however, human papillomavirus (HPV) and herpes simplex virus (HSV) vaccination had little to no impact on stillbirths, ectopic pregnancies, and congenital anomalies. However, one review reported an increased risk of miscarriages among young adults associated with these vaccinations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The scoping review identified a scarcity of evidence on preconception risk factors and interventions among adolescents and young adults. This underscores the crucial need for additional research on the subject.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0300177","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T17:40:34Z","timestamp":1713375634000},"page":"e0300177","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring preconception health in adolescents and young adults: Identifying risk factors and interventions to prevent adverse maternal, perinatal, and child health outcomes\u2013A scoping review"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-7565","authenticated-orcid":true,"given":"Zahra Ali","family":"Padhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-6644","authenticated-orcid":true,"given":"Komal Abdul","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizachew A.","family":"Tessema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie C.","family":"Avery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin Mirzaei","family":"Damabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patience","family":"Castleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehana A.","family":"Salam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima","family":"Meherali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-6334","authenticated-orcid":true,"given":"Zohra S.","family":"Lassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"pone.0300177.ref001","volume-title":"Preconception Health and Health Care Is Important For All","author":"Centers for Disease Control and Prevention","year":"2023"},{"issue":"6","key":"pone.0300177.ref002","doi-asserted-by":"crossref","first-page":"e0270158","DOI":"10.1371\/journal.pone.0270158","article-title":"Preconception risk factors and health care needs of pregnancy-planning women and men with a lifetime history or current mental illness: A nationwide survey.","volume":"17","author":"C-L Dennis","year":"2022","journal-title":"Plos one."},{"key":"pone.0300177.ref003","volume-title":"Healthcare","author":"J Baird","year":"2017"},{"issue":"6","key":"pone.0300177.ref004","article-title":"Recommendations to improve preconception health and Health Care\u2014United States: report of the CDC\/ATSDR preconception care work group and the select panel on preconception care","volume":"55","author":"K Johnson","year":"2006","journal-title":"Morbidity and Mortality Weekly Report: Recommendations and Reports"},{"key":"pone.0300177.ref005","unstructured":"World Health Organization, Meeting to develop a global consensus on preconception care to reduce maternal and childhood mortality and morbidity. 2013, World Health Organization,: Geneva."},{"key":"pone.0300177.ref006","volume-title":"Systematic review of preconception risks and interventions.","author":"SV Dean","year":"2013"},{"issue":"3","key":"pone.0300177.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4755-11-S3-S1","article-title":"Preconception care: closing the gap in the continuum of care to accelerate improvements in maternal, newborn and child health.","volume":"11","author":"SV Dean","year":"2014","journal-title":"Reproductive Health"},{"issue":"3","key":"pone.0300177.ref008","first-page":"1","article-title":"Preconception care: nutritional risks and interventions.","volume":"11","author":"SV Dean","year":"2014","journal-title":"Reproductive health."},{"key":"pone.0300177.ref009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4755-11-S3-S5","article-title":"Preconception care: screening and management of chronic disease and promoting psychological health.","volume":"11","author":"ZS Lassi","year":"2014","journal-title":"Reproductive Health."},{"issue":"3","key":"pone.0300177.ref010","first-page":"1","article-title":"Preconception 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Hemsing","year":"2017","journal-title":"Sexual & reproductive healthcare."},{"issue":"3","key":"pone.0300177.ref026","first-page":"1","article-title":"Preconception care: advancing from \u2018important to do and can be done\u2019to \u2018is being done and is making a difference\u2019.","volume":"11","author":"E Mason","year":"2014","journal-title":"Reproductive health."},{"key":"pone.0300177.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12978-020-00913-y","article-title":"Psychosocial interventions targeting mental health in pregnant adolescents and adolescent parents: a systematic review.","volume":"17","author":"CA Laurenzi","year":"2020","journal-title":"Reproductive health."},{"key":"pone.0300177.ref028","doi-asserted-by":"crossref","first-page":"102274","DOI":"10.1016\/j.pmedr.2023.102274","article-title":"Investigating the Pathways From Preconception Care to Preventing Maternal, Perinatal and Child Mortality: A Scoping Review and Causal Loop Diagram.","author":"S Poix","year":"2023","journal-title":"Preventive Medicine Reports."},{"key":"pone.0300177.ref029","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijnurstu.2018.06.009","article-title":"Barriers and facilitators to the provision of preconception care by healthcare providers: a systematic review.","volume":"87","author":"J Goossens","year":"2018","journal-title":"International journal of nursing studies"},{"issue":"1","key":"pone.0300177.ref030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/nyas.13335","article-title":"Systematic review on evidence-based adolescent nutrition interventions","volume":"1393","author":"ZS Lassi","year":"2017","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"pone.0300177.ref031","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation.","volume":"169","author":"AC Tricco","year":"2018","journal-title":"Annals of internal medicine"},{"key":"pone.0300177.ref032","unstructured":"WHO. Meeting to develop a global consensus on preconception care to reduce maternal and childhood mortality and morbidity. 2022."},{"key":"pone.0300177.ref033","unstructured":"WHO. Preconception care. Report of a regional expert group consultation 6\u20138 August 2013, New Delhi, India. 2014."},{"issue":"2","key":"pone.0300177.ref034","article-title":"Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby.","author":"SK Abe","year":"2016","journal-title":"Cochrane Database of Systematic Reviews."},{"issue":"5","key":"pone.0300177.ref035","first-page":"725","article-title":"Youth-Friendly Family Planning Services for Young People: A Systematic Review Update. Am J Prev Med.","volume":"55","author":"AW Brittain","year":"2018"},{"issue":"2","key":"pone.0300177.ref036","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2337\/db09-1166","article-title":"Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies","volume":"59","author":"CR Cardwell","year":"2010","journal-title":"Diabetes"},{"issue":"4","key":"pone.0300177.ref037","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.rpped.2015.02.006","article-title":"Safety of human papillomavirus 6, 11, 16 and 18 (recombinant): systematic review and meta-analysis.","volume":"33","author":"PLS Coelho","year":"2015","journal-title":"Revista Paulista de Pediatria"},{"key":"pone.0300177.ref038","article-title":"Reproductive Outcomes After a Childhood and Adolescent Young Adult Cancer Diagnosis in Female Cancer Survivors: A Systematic Review and Meta-analysis.","author":"B Gerstl","year":"2018","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"Suppl 1","key":"pone.0300177.ref039","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-3016.2012.01290.x","article-title":"The impact of early age at first childbirth on maternal and infant health.","volume":"26","author":"CM Gibbs","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"9","key":"pone.0300177.ref040","doi-asserted-by":"crossref","first-page":"e0204327","DOI":"10.1371\/journal.pone.0204327","article-title":"Complications associated with adolescent childbearing in Sub-Saharan Africa: A systematic literature review and meta-analysis.","volume":"13","author":"T Gr\u00f8nvik","year":"2018","journal-title":"PloS one"},{"issue":"3","key":"pone.0300177.ref041","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/17453674.2016.1153359","article-title":"Association between maternal age at conception and risk of idiopathic clubfoot.","volume":"87","author":"Y-b Liu","year":"2016","journal-title":"Acta Orthopaedica."},{"issue":"13","key":"pone.0300177.ref042","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.vaccine.2013.01.002","article-title":"Meta-analysis of pregnancy outcomes in pooled randomized trials on a prophylactic adjuvanted glycoprotein D subunit herpes simplex virus vaccine","volume":"31","author":"F Tavares","year":"2013","journal-title":"Vaccine"},{"key":"pone.0300177.ref043","first-page":"340","article-title":"Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials.","author":"S Wacholder","year":"2010","journal-title":"Bmj"},{"issue":"3","key":"pone.0300177.ref044","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/adc.2007.115915","article-title":"Teenage pregnancy: who suffers","volume":"94","author":"S Paranjothy","year":"2009","journal-title":"Arch Dis Child"},{"issue":"2","key":"pone.0300177.ref045","first-page":"342","volume":"192","author":"A Conde-Agudelo","year":"2005","journal-title":"Maternal-perinatal morbidity and mortality associated with adolescent pregnancy in Latin America: Cross-sectional study. American journal of obstetrics and gynecology"},{"issue":"1","key":"pone.0300177.ref046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-5-79","article-title":"Socioeconomic factors and adolescent pregnancy outcomes: distinctions between neonatal and post-neonatal deaths?","volume":"5","author":"BP Markovitz","year":"2005","journal-title":"BMC Public Health"},{"issue":"9","key":"pone.0300177.ref047","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1001\/archpedi.162.9.828","article-title":"Young maternal age and the risk of neonatal mortality in rural Nepal","volume":"162","author":"V Sharma","year":"2008","journal-title":"Archives of pediatrics & adolescent medicine"},{"issue":"5","key":"pone.0300177.ref048","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/ije\/dyr084","article-title":"Mechanisms underlying the associations of maternal age with adverse perinatal outcomes: a sibling study of 264 695 Danish women and their firstborn offspring","volume":"40","author":"DA Lawlor","year":"2011","journal-title":"International journal of epidemiology"},{"issue":"1","key":"pone.0300177.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-11-781","article-title":"Childbearing during adolescence and offspring mortality: findings from three population-based cohorts in southern Brazil.","volume":"11","author":"MC Restrepo-M\u00e9ndez","year":"2011","journal-title":"BMC public health"},{"issue":"2","key":"pone.0300177.ref050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S0021932000002297","article-title":"Teenage motherhood and infant mortality in Bangladesh: maternal age-dependent effect of parity one.","volume":"32","author":"N. 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