{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:19:52Z","timestamp":1789885192620,"version":"4.0.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy at Ho Chi Minh City","award":["03\/2020\/H\u0110-\u0110HYD"],"award-info":[{"award-number":["03\/2020\/H\u0110-\u0110HYD"]}]},{"DOI":"10.13039\/501100015501","name":"Qu\u1ef9 \u0110\u1ed5i m\u1edbi s\u00e1ng t\u1ea1o Vingroup","doi-asserted-by":"publisher","award":["VINIF.2022.TS027"],"award-info":[{"award-number":["VINIF.2022.TS027"]}],"id":[{"id":"10.13039\/501100015501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The pathogenesis and prognosis of patients with acute myocardial infarction (AMI) may be influenced by both genetic and environmental factors. Findings on the relationship of polymorphisms in various genes encoding the renin-angiotensin-aldosterone system with coronary artery lesions and mortality in AMI patients are inconsistent. The aim of this study was to determine whether the<jats:italic>AGTR1<\/jats:italic>A1166C genetic polymorphism affects coronary artery lesions and 1-year mortality in post-AMI patients. Patients with their first AMI admitted to Cho Ray Hospital, Vietnam, from January 2020 to August 2021 were enrolled in this prospective clinical study. All participants underwent invasive coronary angiography and were identified as having the genotypes of<jats:italic>AGTR1<\/jats:italic>A1166C by way of a polymerase chain reaction method. All patients were followed up for all-cause mortality 12 months after AMI. The association of the<jats:italic>AGTR1<\/jats:italic>A1166C polymorphism with coronary artery lesions and 1-year mortality was evaluated using logistic regression and Cox regression analysis, respectively. Five hundred and thirty-one AMI patients were recruited. The mean age was 63.9 \u00b1 11.6 years, and 71.6% of the patients were male. There were no significant differences in the location and number of diseased coronary artery branches between the AA and AC+CC genotypes. The AC and CC genotypes were independently associated with \u2265 90% diameter stenosis of the left anterior descending (LAD) artery (odds ratio = 1.940; 95% confidence interval (CI): 1.059\u20133.552,<jats:italic>p<\/jats:italic>= 0.032). The 1-year all-cause mortality rate difference between patients with the AC and CC genotypes versus those with the AA genotype was not statistically significant (hazard ratio = 1.000, 95% CI: 0.429\u20132.328,<jats:italic>p<\/jats:italic>= 1.000). The<jats:italic>AGTR1<\/jats:italic>A1166C genetic polymorphism is associated with very severe luminal stenosis of the LAD but not with mortality in AMI patients.<\/jats:p>","DOI":"10.1371\/journal.pone.0300273","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T18:08:47Z","timestamp":1713463727000},"page":"e0300273","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of AGTR1 A1166C genetic polymorphism on coronary artery lesions and mortality in patients with acute myocardial infarction"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-2600","authenticated-orcid":true,"given":"Duy Cong","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Hoang Gia","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truc Thanh","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sy","family":"Van Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-6390","authenticated-orcid":true,"given":"Minh Duc","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binh Quang","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"pone.0300273.ref001","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","journal-title":"Lancet Lond Engl"},{"key":"pone.0300273.ref002","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth Universal Definition of Myocardial Infarction (2018)","volume":"72","author":"K Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"pone.0300273.ref003","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/ijpvm.IJPVM_122_20","article-title":"The Reduction of Mortality in Acute Myocardial Infarction: From Bed Rest to Future Directions","volume":"13","author":"PL Laforgia","year":"2022","journal-title":"Int J Prev Med"},{"key":"pone.0300273.ref004","first-page":"1","article-title":"Genetic Markers of Myocardial Infarction","volume":"0","author":"S Kariz","year":"2012","journal-title":"Clin Exp Cardiol"},{"key":"pone.0300273.ref005","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1113\/expphysiol.2004.028456","article-title":"Polymorphism in angiotensin II receptor genes and hypertension","volume":"90","author":"B. 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