{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T01:11:16Z","timestamp":1713489076547},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ocular Physiology Research & Education Foundation"},{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison NIH base","award":["5P51 RR 000167"],"award-info":[{"award-number":["5P51 RR 000167"]}]},{"name":"NIH Core Grant for Vision Research","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"NEI","award":["R01 EY025359-01A1, RO1 EY10213, R21 EY018370-01A2, and R21 EY018370-01A2S1"],"award-info":[{"award-number":["R01 EY025359-01A1, RO1 EY10213, R21 EY018370-01A2, and R21 EY018370-01A2S1"]}]},{"name":"Research to Prevent Blindness unrestricted Departmental Challenge Grant"},{"name":"Department of Ophthalmology & Visual Sciences"},{"name":"Intramural Research Program of the National Institute on Aging, NIH"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To determine the effect of sex as a risk factor regarding presbyopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Maximum accommodation was pharmacologically induced (40% cabachol corneal iontophoresis) in 97 rhesus monkeys (49 males and 48 females) ranging in age from 8 to 36 years old. Accommodation was measured by Hartinger coincidence refractometry.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Accommodative amplitude measured refractometrically decreased with age, and the rate of change was not different between males and females (p = 0.827).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Presbyopia is essentially sex neutral, and no one is spared. There may be modest variations between different populations for various reasons, but essentially it is monotonously predictable. At present there is no biological therapeutic.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0300476","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T17:45:52Z","timestamp":1713462352000},"page":"e0300476","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex as a risk factor regarding presbyopia in the rhesus monkey"],"prefix":"10.1371","volume":"19","author":[{"given":"Mary Ann","family":"Croft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared P.","family":"Mcdonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Kiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Mattison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"issue":"3","key":"pone.0300476.ref001","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1167\/iovs.09-4008","article-title":"Morphology and accommodative function of the vitreous zonule in human and monkey eyes","volume":"51","author":"E. L\u00fctjen-Drecoll","year":"2010","journal-title":"Invest Ophthalmol and Vis Sci"},{"key":"pone.0300476.ref002","first-page":"23","article-title":"Age-dependent loss of accommodative amplitude in rhesus monkeys: an animal model for presbyopia","volume":"23","author":"L.Z. Bito","year":"1982","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"pone.0300476.ref003","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0002-9394(22)90793-7","article-title":"Studies in monocular and binocular accommodation with their clinical applications","volume":"5","author":"A. Duane","year":"1922","journal-title":"Am J Ophthalmol"},{"key":"pone.0300476.ref004","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00006324-200106000-00014","article-title":"Ultrasound biomicroscopy of the aging rhesus monkey ciliary region","volume":"78","author":"A. Glasser","year":"2001","journal-title":"Opt Vis Sci,"},{"key":"pone.0300476.ref005","first-page":"863","article-title":"The mechanism of accommodation in primates","volume":"106","author":"A. Glasser","year":"1999","journal-title":"Ophthalmology"},{"key":"pone.0300476.ref006","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1167\/iovs.04-1523","article-title":"PL., Accommodative ciliary body and lens function in rhesus monkeys. I. Normal lens, zonule and ciliary process configuration in the iridectomized eye","volume":"47","author":"M.G. Croft","year":"2006","journal-title":"Invest Ophthalmol and Vis Sci,"},{"key":"pone.0300476.ref007","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1167\/iovs.04-1524","article-title":"The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye","volume":"47","author":"M.A. Croft","year":"2006","journal-title":"Invest Ophthalmol and Vis Sci"},{"key":"pone.0300476.ref008","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1167\/iovs.08-1916","article-title":"Surgical intervention and accommodative responses: I. Centripetal ciliary body, capsule, and lens movement in rhesus monkeys of various ages","volume":"49","author":"M. Croft","year":"2008","journal-title":"Invest Ophthalmol and Vis Sci,"},{"key":"pone.0300476.ref009","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.exer.2009.07.009","article-title":"Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys","volume":"89","author":"M. Croft","year":"2009","journal-title":"Exp Eye Res"},{"key":"pone.0300476.ref010","first-page":"5495","article-title":"Surgical intervention and accommodative responses","author":"R. Wasielewski","year":"2008","journal-title":"II. Forward ciliary body accommodative movement is facilitated by zonular attachments to the lens capsule. Invest Ophthalmol and Vis Sci"},{"key":"pone.0300476.ref011","first-page":"33","article-title":"Accommodative movements of the lens\/capsule and the strand that extends between the posterior vitreous zonule insertion zone & the lens equator, in relation to the vitreous face and aging","volume":"36","author":"M.A. Croft","year":"2015","journal-title":"Ophthalmic and Physiological Optics"},{"key":"pone.0300476.ref012","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.exer.2016.07.007","article-title":"Age-related posterior ciliary muscle restriction\u2014a link between trabecular meshwork and optic nerve head pathophysiology","volume":"158","author":"M.A. Croft","year":"2016","journal-title":"Exp Eye Res"},{"key":"pone.0300476.ref013","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1167\/iovs.12-10846","article-title":"Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes","volume":"54","author":"M.A. Croft","year":"2013","journal-title":"Invest Ophthalmol and Vis Sci"},{"key":"pone.0300476.ref014","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1167\/iovs.12-10847","article-title":"Accommodative movements of the vitreous membrane, choroid and sclera in young and presbyopic human and nonhuman primate eyes","volume":"54","author":"M.A. Croft","year":"2013","journal-title":"Invest Ophthalmol and Vis Sci"},{"key":"pone.0300476.ref015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11357-005-4005-8","article-title":"Accommodative function in rhesus monkeys: effects of aging and calorie restriction.","volume":"27","author":"J.A. Mattison","year":"2005","journal-title":"Age"},{"key":"pone.0300476.ref016","doi-asserted-by":"crossref","first-page":"B148","DOI":"10.1093\/geronj\/45.5.B148","article-title":"Dietary restriction and aging: the initiation of a primate study","volume":"45","author":"D.K. Ingram","year":"1990","journal-title":"Journal of Gerontology"},{"key":"pone.0300476.ref017","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0014-4835(87)80153-7","article-title":"Slit-lamp studies of the rhesus monkey eye: II. Changes in crystalline lens shape, thickness and position during accommodation and aging","volume":"45","author":"J.F. Koretz","year":"1987","journal-title":"Experimental Eye Research"},{"key":"pone.0300476.ref018","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(89)91673-9","article-title":"Reproducible stimulation of ciliary muscle contraction in the cynomolgus monkey via a permanent indwelling midbrain electrode","volume":"503","author":"K. Crawford","year":"1989","journal-title":"Brain Research"},{"key":"pone.0300476.ref019","first-page":"3215","article-title":"Meta-analysis of sex differences in presbyopia","volume":"53","author":"A. Hickenbotham","year":"2012","journal-title":"Clin and Epidem Res"},{"key":"pone.0300476.ref020","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1475-1313.1995.9400022r.x","article-title":"The presbyopic add. II. Age-related trend and a gender difference","volume":"15","author":"J. Pointer","year":"1995","journal-title":". Ophthalmic Physiol Opt"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0300476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T17:46:27Z","timestamp":1713462387000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0300476"}},"subtitle":[],"editor":[{"given":"Andrzej","family":"Grzybowski","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0300476","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}