{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:21:18Z","timestamp":1747196478721,"version":"3.40.5"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Concern exists about the increasing risk of postoperative pulmonary complications in patients with a history of coronavirus disease 2019 (COVID-19).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>We conducted a prospective observational study that compared the incidence of postoperative pulmonary complications in patients with and without a history of COVID-19.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>From August 2022 to November 2022, 244 adult patients undergoing major non-cardiac surgery were enrolled and allocated either to history or no history of COVID-19 groups. For patients without a history of confirming COVID-19 diagnosis, we tested immunoglobulin G to nucleocapsid antigen of SARS-CoV-2 for serology assessment to identify undetected infection. We compared the incidence of postoperative pulmonary complications, defined as a composite of atelectasis, pleural effusion, pulmonary edema, pneumonia, aspiration pneumonitis, and the need for additional oxygen therapy according to a COVID-19 history.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>After excluding 44 patients without a COVID-19 history who were detected as seropositive, 200 patients were finally enrolled in this study, 100 in each group. All subjects with a COVID-19 history experienced no or mild symptoms during infection. The risk of postoperative pulmonary complications was not significantly different between the groups according to the history of COVID-19 (24.0% vs. 26.0%; odds ratio, 0.99; 95% confidence interval, 0.71\u20131.37; P-value, 0.92). The incidence of postoperative pulmonary complications was also similar (27.3%) in excluded patients owing to being seropositive.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our study showed patients with a history of no or mild symptomatic COVID-19 did not show an increased risk of PPCs compared to those without a COVID-19 history. Additional precautions may not be needed to prevent PPCs in those patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0300782","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T17:30:49Z","timestamp":1716312649000},"page":"e0300782","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does coronavirus disease 2019 history alone increase the risk of postoperative pulmonary complications after surgery? Prospective observational study using serology assessment"],"prefix":"10.1371","volume":"19","author":[{"given":"Ah Ran","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Suk","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungchan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangmin Maria","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mijeong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-5550","authenticated-orcid":true,"given":"Jong-Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"unstructured":"WHO. Rolling updates on coronavirus disease (COVID-19). July 31, 2020. [cited 2023 March 19]. Available from: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/events-as-they-happen.","key":"pone.0300782.ref001"},{"issue":"5","key":"pone.0300782.ref002","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"E. Dong","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pone.0300782.ref003","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40246-022-00392-1","article-title":"COVID-19 2022 update: transition of the pandemic to the endemic phase","volume":"16","author":"M. Biancolella","year":"2022","journal-title":"Hum Genomics"},{"issue":"3","key":"pone.0300782.ref004","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/bja\/aex002","article-title":"Postoperative pulmonary complications","volume":"118","author":"A. Miskovic","year":"2017","journal-title":"Br J Anaesth"},{"issue":"10243","key":"pone.0300782.ref005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(20)31182-X","article-title":"Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study","volume":"396","author":"COVIDSurg Collaborative","year":"2020","journal-title":"Lancet"},{"issue":"24","key":"pone.0300782.ref006","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1056\/NEJMc2010419","article-title":"Clinical Characteristics of Covid-19 in New York City","volume":"382","author":"P. Goyal","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"pone.0300782.ref007","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1097\/SLA.0000000000003925","article-title":"COVID-19 Outbreak and Surgical Practice: Unexpected Fatality in Perioperative Period","volume":"272","author":"A. Aminian","year":"2020","journal-title":"Ann Surg"},{"issue":"2","key":"pone.0300782.ref008","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/SLA.0000000000005308","article-title":"The Risk of Postoperative Complications After Major Elective Surgery in Active or Resolved COVID-19 in the United States","volume":"275","author":"J.Z. Deng","year":"2022","journal-title":"Ann Surg"},{"issue":"2","key":"pone.0300782.ref009","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.amjsurg.2020.12.024","article-title":"Periprocedural complications in patients with SARS-CoV-2 infection compared to those without infection: A nationwide propensity-matched analysis","volume":"222","author":"B.K. Lal","year":"2021","journal-title":"Am J Surg"},{"issue":"2","key":"pone.0300782.ref010","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.surg.2020.09.022","article-title":"Perioperative SARS-CoV-2 infections increase mortality, pulmonary complications, and thromboembolic events: A Dutch, multicenter, matched-cohort clinical study","volume":"169","author":"P.K.C. Jonker","year":"2021","journal-title":"Surgery"},{"issue":"6","key":"pone.0300782.ref011","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/anae.15458","article-title":"COVIDSurg Collaborative and GlobalSurg Collaborative, Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study","volume":"76","year":"2021","journal-title":"Anaesthesia"},{"issue":"4","key":"pone.0300782.ref012","doi-asserted-by":"crossref","first-page":"e0248946","DOI":"10.1371\/journal.pone.0248946","article-title":"Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: Systematic review","volume":"16","author":"O. Byambasuren","year":"2021","journal-title":"PLoS One"},{"issue":"4","key":"pone.0300782.ref013","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Z. Xu","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"16","key":"pone.0300782.ref014","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.3390\/jcm10163508","article-title":"D-dimer levels are not elevated in SARS-CoV-2 IgG positive patients undergoing elective orthopedic surgery","volume":"10","author":"A. Jungwirth-Weinberger","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"pone.0300782.ref015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.artd.2021.11.021","article-title":"History of COVID-19 was not associated with length of stay or in-hospital complications after elective lower extremity joint replacement","volume":"13","author":"A. Jungwirth-Weinberger","year":"2022","journal-title":"Arthroplasty today"},{"issue":"5","key":"pone.0300782.ref016","doi-asserted-by":"crossref","first-page":"e1136","DOI":"10.1002\/cti2.1136","article-title":"Detection of IgM and IgG antibodies in patients with coronavirus disease 2019","volume":"9","author":"H. Hou","year":"2020","journal-title":"Clinical & translational immunology"},{"unstructured":"Elecsys\u00ae Anti-SARS-CoV-2. Package Insert 2020\u201307, V3.0; Material Numbers 09203095190 and 09203079190.","key":"pone.0300782.ref017"},{"issue":"2","key":"pone.0300782.ref018","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1001\/jamasurg.2016.4102","article-title":"Postoperative Pulmonary Complications-A Multifactorial Outcome","volume":"152","author":"K.L. Haines","year":"2017","journal-title":"JAMA Surg"},{"issue":"19","key":"pone.0300782.ref019","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.3390\/jcm11195865","article-title":"Association between Mortality and Sequential Organ Failure Assessment Score during a Short Stay in the Intensive Care Unit after Non-Cardiac Surgery","volume":"11","author":"A.R. Oh","year":"2022","journal-title":"J Clin Med"},{"issue":"9","key":"pone.0300782.ref020","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/bjs.11646","article-title":"Global guidance for surgical care during the COVID-19 pandemic","volume":"107","author":"COVIDSurg Collaborative","year":"2020","journal-title":"Br J Surg"},{"issue":"1","key":"pone.0300782.ref021","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13037-020-00262-6","article-title":"Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis","volume":"14","author":"S.M. Abate","year":"2020","journal-title":"Patient Saf Surg"},{"issue":"1","key":"pone.0300782.ref022","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/SLA.0000000000003923","article-title":"Managing COVID-19 in Surgical Systems","volume":"272","author":"M.E. Brindle","year":"2020","journal-title":"Ann Surg"},{"issue":"8","key":"pone.0300782.ref023","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4240\/wjgs.v13.i8.788","article-title":"Surgical complications in COVID-19 patients in the setting of moderate to severe disease","volume":"13","author":"M. Gulinac","year":"2021","journal-title":"World J Gastrointest Surg"},{"issue":"8","key":"pone.0300782.ref024","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s00268-020-05575-2","article-title":"Hazardous Postoperative Outcomes of Unexpected COVID-19 Infected Patients: A Call for Global Consideration of Sampling all Asymptomatic Patients Before Surgical Treatment","volume":"44","author":"C. Nahshon","year":"2020","journal-title":"World J Surg"},{"issue":"1","key":"pone.0300782.ref025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12871-021-01233-9","article-title":"Postoperative outcomes in surgical COVID-19 patients: a multicenter cohort study","volume":"21","author":"F.M. Carrier","year":"2021","journal-title":"BMC Anesthesiol"},{"issue":"3","key":"pone.0300782.ref026","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5435\/JAAOS-D-22-00548","article-title":"Postoperative Outcomes in Patients Undergoing Orthopaedic Surgery Within 90 Days of Coronavirus Disease 2019","volume":"31","author":"A.H. 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Ejazi","year":"2021","journal-title":"Immunol Cell Biol"},{"issue":"12","key":"pone.0300782.ref030","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients","volume":"382","author":"L. Zou","year":"2020","journal-title":"N Engl J Med"},{"issue":"2","key":"pone.0300782.ref031","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00408-021-00423-z","article-title":"Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?","volume":"199","author":"D.L. Sykes","year":"2021","journal-title":"Lung"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0300782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T17:31:09Z","timestamp":1716312669000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0300782"}},"subtitle":[],"editor":[{"given":"Yuyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0300782","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2024,5,21]]}}}