{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:02:22Z","timestamp":1787022142966,"version":"build-2736575974"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer Oy","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Migraine is a common chronic brain disorder, characterized by recurring and often disabling attacks of severe headache, with additional symptoms such as photophobia, phonophobia and nausea. Migraine affects especially the working age population. The objective of this retrospective observational register-based study was to analyze the use of healthcare services and associated costs in Finnish migraine patients. Study was based on aggregate data from January 1\n                    <jats:sup>st<\/jats:sup>\n                    , 2020, to December 31\n                    <jats:sup>st<\/jats:sup>\n                    , 2021, from the Finnish Institute for Health and Welfare\u2019s national registries. Patients were grouped into nine patient groups according to medication prescriptions and diagnoses. Healthcare resource utilization in specialty, primary, and occupational healthcare was assessed and analyzed separately for all-cause and migraine related healthcare contacts from a one-year period. The total number of patients was 175 711, and most (45%) of the patients belonged to a group that had used only one triptan. Migraine related total healthcare resource utilization was greater for patients that had used two or more triptans compared to those that had used only one. The patients with three or more preventive medications had the highest total migraine related healthcare resource utilization of the studied patient cohorts. Of the total annual healthcare costs 11.5% (50.6 million \u20ac) was associated to be migraine related costs. Total per patient per year healthcare costs were highest with patients that had used three or more preventive medications (5 626 \u20ac) and lowest in those with only one triptan (2 257 \u20ac). Our findings are in line with the recent European Headache Federation consensus statement regarding the unmet need in patients who have had inadequate response to two or more triptans. When assessing the patient access and cost-effectiveness of novel treatments for the treatment of migraine within different healthcare systems, a holistic analysis of the current disease burden along with potential gains for patients and healthcare service providers are essential information in guiding decision-making.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0300816","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:32:07Z","timestamp":1710941527000},"page":"e0300816","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Healthcare resource utilization and associated costs among patients with migraine in Finland: A retrospective register-based study"],"prefix":"10.1371","volume":"19","author":[{"given":"Mikko","family":"Kosunen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severi","family":"Niskanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roope","family":"Mets\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Kainu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-0196","authenticated-orcid":true,"given":"Mari","family":"Lahelma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Isomeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"pone.0300816.ref001","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-021-00328-4","article-title":"Migraine","volume":"8","author":"MD Ferrari","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"pone.0300816.ref002","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0140-6736(18)30478-1","article-title":"Migraine","volume":"391","author":"DW Dodick","year":"2018","journal-title":"The Lancet"},{"key":"pone.0300816.ref003","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension-type headache, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"LJ Stovner","year":"2018","journal-title":"Lancet Neurol"},{"key":"pone.0300816.ref004","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-022-01402-2","article-title":"The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates","volume":"23","author":"LJ Stovner","year":"2022","journal-title":"J Headache Pain"},{"key":"pone.0300816.ref005","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-020-01185-4","article-title":"My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland","volume":"21","author":"ML Sumelahti","year":"2020","journal-title":"J Headache Pain"},{"key":"pone.0300816.ref006","unstructured":"The Working Group Set up by the Finnish Medical Society Duodecim the FS of N. Migraine\u2014Current Care Summary. In: 2015 [Internet]. [cited 17 Nov 2023]. https:\/\/www.kaypahoito.fi\/en\/ccs00048."},{"key":"pone.0300816.ref007","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/head.12601","article-title":"Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta-Analysis","volume":"55","author":"C Cameron","year":"2015","journal-title":"Headache: The Journal of Head and Face Pain"},{"key":"pone.0300816.ref008","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/head.12164","article-title":"Effects of Switching Acute Treatment on Disability in Migraine Patients Using Triptans","volume":"53","author":"D Serrano","year":"2013","journal-title":"Headache: The Journal of Head and Face Pain"},{"key":"pone.0300816.ref009","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1368-5031.2004.00292.x","article-title":"Switching patients with migraine from sumatriptan to other triptans increases primary care costs","volume":"58","author":"N Savani","year":"2004","journal-title":"Int J Clin Pract"},{"key":"pone.0300816.ref010","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-022-01502-z","article-title":"European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure","volume":"23","author":"S Sacco","year":"2022","journal-title":"J Headache Pain"},{"key":"pone.0300816.ref011","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies\u2014successful translation from bench to clinic","volume":"14","author":"L Edvinsson","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"pone.0300816.ref012","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1177\/0333102416678382","article-title":"Persistence and switching patterns of oral migraine prophylactic medications among patients with chronic migraine: A retrospective claims analysis","volume":"37","author":"Z Hepp","year":"2017","journal-title":"Cephalalgia"},{"key":"pone.0300816.ref013","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s40122-021-00331-3","article-title":"Burden of Migraine in Patients With Preventive Treatment Failure Attending European Headache Specialist Centers: Real-World Evidence From the BECOME Study","volume":"10","author":"P Pozo-Rosich","year":"2021","journal-title":"Pain Ther"},{"key":"pone.0300816.ref014","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-018-0946-z","article-title":"My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed","volume":"19","author":"P Martelletti","year":"2018","journal-title":"J Headache Pain"},{"key":"pone.0300816.ref015","unstructured":"Faktaa ty\u00f6terveyshuollosta\u2014rooli ja mahdollisuudet sotessa | Ty\u00f6terveyslaitos. [cited 17 Nov 2023]. https:\/\/www.ttl.fi\/faktaa-tyoterveyshuollosta-rooli-ja-mahdollisuudet-sotessa."},{"key":"pone.0300816.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-019-0964-5","article-title":"Burden of migraine in Finland: Health care resource use, sick-leaves and comorbidities in occupational health care","volume":"20","author":"MA Korolainen","year":"2019","journal-title":"Journal of Headache and Pain"},{"key":"pone.0300816.ref017","unstructured":"M\u00e4klin S, Kokko P. Terveyden- ja sosiaalihuollon yksikk\u00f6kustannukset Suomessa vuonna 2017. Terveyden ja hyvinvoinnin laitos (Institute of Health and Welfare). 2021 [cited 17 Nov 2023]. https:\/\/www.julkari.fi\/handle\/10024\/142882."},{"key":"pone.0300816.ref018","unstructured":"Price index of public expenditure\u2014Statistics Finland. [cited 17 Nov 2023]. https:\/\/www.stat.fi\/en\/statistics\/jmhi."},{"key":"pone.0300816.ref019","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/head.14259","article-title":"Diagnosis, consultation, treatment, and impact of migraine in the US: Results of the OVERCOME (US) study","volume":"62","author":"RB Lipton","year":"2022","journal-title":"Headache"},{"key":"pone.0300816.ref020","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10198-022-01507-0","article-title":"Obesity and metabolic state are associated with increased healthcare resource and medication use and costs: a Finnish population-based study","volume":"24","author":"A Vesikansa","year":"2023","journal-title":"European Journal of Health Economics"},{"key":"pone.0300816.ref021","doi-asserted-by":"crossref","DOI":"10.1186\/s12888-022-04115-7","article-title":"Healthcare utilization, costs, and productivity losses in treatment-resistant depression in Finland\u2014a matched cohort study","volume":"22","author":"H Taipale","year":"2022","journal-title":"BMC Psychiatry"},{"key":"pone.0300816.ref022","first-page":"1659","volume":"31","author":"ML Sumelahti","year":"2017","journal-title":"Prescription patterns in preventive and abortive migraine medication"},{"key":"pone.0300816.ref023","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s40261-019-00827-z","article-title":"Cost-Effectiveness Analysis of Erenumab Versus OnabotulinumtoxinA for Patients with Chronic Migraine Attacks in Greece","volume":"39","author":"T V. Giannouchos","year":"2019","journal-title":"Clin Drug Investig"},{"key":"pone.0300816.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-022-01492-y","article-title":"A systematic review of economic evaluations of pharmacological treatments for adults with chronic migraine","volume":"23","author":"S Khanal","year":"2022","journal-title":"Journal of Headache and Pain"},{"key":"pone.0300816.ref025","first-page":"2027","article-title":"Koko Suomen perusterveydenhuollon asiakaskirjo on nyt kuvattu","volume":"74","author":"E Ketola","year":"2019","journal-title":"Suomen l\u00e4\u00e4k\u00e4rilehti"},{"key":"pone.0300816.ref026","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-018-0839-1","article-title":"Poor medical care for people with migraine in Europe\u2014evidence from the Eurolight study","volume":"19","author":"Z Katsarava","year":"2018","journal-title":"J Headache Pain"},{"key":"pone.0300816.ref027","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1468-1331.2011.03590.x","article-title":"The economic cost of brain disorders in Europe","volume":"19","author":"J Olesen","year":"2012","journal-title":"Eur J Neurol"},{"key":"pone.0300816.ref028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-019-1015-y","article-title":"Burden and costs of migraine in a Swedish defined patient population\u2014A questionnaire-based study","volume":"20","author":"F Hjalte","year":"2019","journal-title":"Journal of Headache and Pain"},{"key":"pone.0300816.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-020-01162-x","article-title":"Economic consequences of migraine in Sweden and implications for the cost-effectiveness of onabotulinumtoxinA (Botox) for chronic migraine in Sweden and Norway","volume":"21","author":"A Hansson-Hedblom","year":"2020","journal-title":"Journal of Headache and Pain"},{"key":"pone.0300816.ref030","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1468-2982.2008.01649.x","article-title":"Sickness absence among female employees with migraine and co-existing conditions","volume":"28","author":"K M\u00e4ki","year":"2008","journal-title":"Cephalalgia"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0300816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:32:42Z","timestamp":1710941562000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0300816"}},"subtitle":[],"editor":[{"given":"Sercan","family":"Erg\u00fcn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,20]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0300816","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,20]]}}}