{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:28:11Z","timestamp":1761719291411,"version":"3.40.5"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic - conceptual development of research organization, Motol University Hospital, Prague, Czech Republic","award":["00064203"],"award-info":[{"award-number":["00064203"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Despite accessible diagnostics and treatment of hypertension, a high proportion of patients worldwide remain unaware of their diagnosis, and even more remain untreated. Several studies suggest that absence of comorbidities is a predictive factor for unawareness and consequently non-treatment of hypertension. There are only a few studies that have assessed the hypertension prevalence and management among apparently healthy individuals.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The aim of the study was to assess and compare hypertension prevalence, awareness, treatment and control among apparently healthy individuals, patients with internal diseases, and patients with non-internal diseases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data from standardised blood pressure measurements conducted during the Czech European Health Examination Survey 2014 and information on health status and health care use collected during the Czech European Health Interview Survey 2014 were analyzed. We focused on participants aged 25\u201364. Data were weighted on sex and age to ensure an appropriate sex and age structure of the population. The \u03c7<jats:sup>2<\/jats:sup>-test and binary logistic regression analyses were used to compare distribution of cascade of care for hypertension between the health-status groups of respondents.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>The final eligible sample consisted of 1121 participants. The prevalence of hypertension was 32.8% in the healthy group, 29.8% in the non-internal disease group and 52.4% in the internal disease group, (p &lt; 0.001). Awareness was 54.1%, 59.1% and 85.2% respectively, (p &lt; 0.001). Treatment was 44.2%, 52.6% and 86.4%, respectively, (p &lt; 0.001). Among apparently healthy respondents 62.6% had their blood pressure measured by a medical professional in the last year, compared to 71.1% in the non-internal disease group and 91.7% in the internal disease group, (p &lt; 0.001). Differences in hypertension control were not statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Generally, our data show a discordance in hypertension management within the Czech population. Apparently healthy individuals are the least aware of their diagnosis and the highest proportion of them remain untreated.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0301202","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T17:48:47Z","timestamp":1714067327000},"page":"e0301202","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cascade of care for hypertension among apparently healthy and unhealthy individuals of 25\u201364 years in the Czech 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Available at: https:\/\/www.zakonyprolidi.cz\/cs\/2012-70; Accessed October 20, 2021"},{"issue":"3","key":"pone.0301202.ref022","doi-asserted-by":"crossref","first-page":"e019965","DOI":"10.1136\/bmjopen-2017-019965","article-title":"Levels of detection of hypertension in primary medical care and interventions to improve detection: a systematic review of the evidence since 2000.","volume":"8","author":"R Baker","year":"2018","journal-title":"BMJ Open"},{"issue":"1","key":"pone.0301202.ref023","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s40292-014-0075-y","article-title":"Why is my hypertensive patient still not controlled?","volume":"22","author":"A Filippi","year":"2015","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"1","key":"pone.0301202.ref024","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1186\/s12889-022-13260-3","article-title":"Prevalence, awareness, treatment and control of hypertension, diabetes and hypercholesterolemia, and associated risk factors in the Czech Republic, Russia, Poland and Lithuania: a cross-sectional study.","volume":"22","author":"W Lu","year":"2022","journal-title":"BMC Public Health."},{"issue":"2","key":"pone.0301202.ref025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1047-2797(02)00257-0","article-title":"Survey non-response in the Netherlands: effects on prevalence estimates and associations.","volume":"13","author":"AJM Van Loon","year":"2003","journal-title":"Ann Epidemiol"},{"key":"pone.0301202.ref026","first-page":"2012","article-title":"Non-response in a nationwide follow-up postal survey in Finland: a register based mortality analysis of respondents and nonrespondents of the Health and Social Support (HeSSup) Study.","author":"S Suominen","year":"2012","journal-title":"BMJ Open"},{"issue":"2","key":"pone.0301202.ref027","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1403494810393557","article-title":"The Danish Health Examination Survey 2007\u20132008 (DANHES 2007\u20132008).","volume":"39","author":"L Eriksen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"3","key":"pone.0301202.ref028","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10654-010-9427-7","article-title":"Selection bias in a population survey with registry linkage: potential effect on socioeconomic gradient in cardiovascular risk","volume":"25","author":"E Strandhagen","year":"2010","journal-title":"Eur J Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0301202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T17:49:07Z","timestamp":1714067347000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0301202"}},"subtitle":[],"editor":[{"given":"Mohanad","family":"Alkhodari","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0301202","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2024,4,25]]}}}