{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:05:50Z","timestamp":1777392350791,"version":"3.51.4"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Hubei Province Health and Family Planning Scientific Research Project","award":["WJ2023M168"],"award-info":[{"award-number":["WJ2023M168"]}]},{"name":"the Principal Investigator Program","award":["HBMUPI202104"],"award-info":[{"award-number":["HBMUPI202104"]}]},{"name":"the Science Research and Development Project of Shiyan","award":["2021K20"],"award-info":[{"award-number":["2021K20"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p><jats:italic>Salmonella<\/jats:italic> is a primary cause of foodborne diseases globally. Despite food contamination and clinical infections garnering substantial attention and research, asymptomatic <jats:italic>Salmonella<\/jats:italic> carriers, potential sources of infection, have been comparatively overlooked. In this study, we conducted a comparative analysis of serotype distribution, antimicrobial resistance phenotypes, and genetic profiles of archived <jats:italic>Salmonella<\/jats:italic> strains isolated from food (26), asymptomatic carriers (41), and clinical cases (47) in Shiyan City, China. Among the 114 <jats:italic>Salmonella<\/jats:italic> strains identified, representing 31 serotypes and 34 Sequence Types (STs), the most prevalent serovars included Typhimurium, Derby, Enteritidis, Thompson, and London, with the most predominant STs being ST11, ST40, ST26, ST34, and ST155. Antimicrobial resistance testing revealed that all strains were only sensitive to meropenem, with 74.6% showing antimicrobial resistance (AMR) and 53.5% demonstrating multidrug resistance (MDR). Strains resistant to five and six classes of antibiotics were the most common. Pearson\u2019s chi-square test showed no statistically significant difference in the occurrence of AMR (<jats:italic>p<\/jats:italic> = 0.105) or MDR (<jats:italic>p<\/jats:italic> = 0.326) among <jats:italic>Salmonella<\/jats:italic> isolates from the three sources. Our findings underscore associations and diversities among <jats:italic>Salmonella<\/jats:italic> strains isolated from food, asymptomatic carriers, and clinical patients, emphasizing the need for increased vigilance towards asymptomatic <jats:italic>Salmonella<\/jats:italic> carriers by authorities.<\/jats:p>","DOI":"10.1371\/journal.pone.0301388","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T17:30:53Z","timestamp":1715275853000},"page":"e0301388","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antimicrobial resistance and genetic relatedness of Salmonella serotypes isolated from food, asymptomatic carriers, and clinical cases in Shiyan, China"],"prefix":"10.1371","volume":"19","author":[{"given":"Jun","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shide","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-0553","authenticated-orcid":true,"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"issue":"7","key":"pone.0301388.ref001","first-page":"526","article-title":"to the White-Kauffmann-Le Minor scheme","volume":"165","author":"S Issenhuth-Jeanjean","year":"2014","journal-title":"Res Microbiol"},{"issue":"1","key":"pone.0301388.ref002","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1038\/s41467-018-06112-5","article-title":"Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits.","volume":"9","author":"Y Seif","year":"2018","journal-title":"Nat Commun"},{"issue":"12","key":"pone.0301388.ref003","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1016\/j.psj.2020.09.071","article-title":"Characterization of integrons and antimicrobial resistance in Salmonella from broilers in Shandong","volume":"99","author":"X Zhao","year":"2020","journal-title":"China. 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