{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:35:20Z","timestamp":1782628520993,"version":"3.54.5"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["23K07726"],"award-info":[{"award-number":["23K07726"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nAltered immunological responses in the palatine tonsils may be involved in the pathogenesis of IgA nephropathy (IgAN). The germinal center serves as the site for antigen-specific humoral immune responses in the palatine tonsils. Germinal center involution is frequently observed in the palatine tonsils of IgAN (IgAN tonsils). However, the pathogenic significance of these characteristic changes remains unclear. This study aimed to investigate the morphological changes in secondary lymphoid follicles in IgAN tonsils and to evaluate the correlation between the morphometric results and the clinicopathological severity of IgAN.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nThe tonsils of age-matched patients with recurrent tonsillitis (RT tonsils) were used as controls. The correlation between the degree of lymphoid follicular involution and histopathological severities in clinical or kidney biopsy was evaluated.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nIn total, 87 patients with IgAN were included (48% male, median age 35 years, median estimated glomerular filtration rate: 74 mL\/min\/1.73 m2<\/jats:sup>). Compared to RT tonsils, IgAN tonsils showed smaller median sizes of lymphoid follicles and germinal centers (P < 0.001). The relative areas of lymphoid follicles (%LFA) and germinal centers (%GCA) in the total tonsillar tissue were smaller in the IgAN tonsils than in the RT tonsils (P < 0.001). In contrast, the median proportion of mantle zones in the total tonsillar tissue was comparable between the groups. A lower %LFA was associated with a longer period from the onset of urinary abnormalities to biopsy diagnosis and higher urinary protein excretion (P = 0.01). %LFA showed significant negative correlations with frequencies of glomeruli with both global and segmental sclerosis.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nThe present study confirmed accelerated germinal center involution in the tonsils of patients with IgAN. This characteristic change in the IgAN tonsil correlates with heavy proteinuria and advanced chronic histopathological changes in the kidneys, thereby suggesting the involvement of repeated tonsillar immunoreactions during IgAN progression.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0301853","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T17:49:50Z","timestamp":1715017790000},"page":"e0301853","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Accelerated involution of germinal center in palatine tonsils in IgA nephropathy"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-2208","authenticated-orcid":true,"given":"Hiroyuki","family":"Ueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-3664","authenticated-orcid":true,"given":"Kensuke","family":"Joh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Marumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yokoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"pone.0301853.ref001","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0272-6386(97)90333-4","article-title":"Natural history and risk factors for immunoglobulin a nephropathy in Japan","volume":"29","author":"A Koyama","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"pone.0301853.ref002","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0272-6386(12)80284-8","article-title":"Prognostic Factors in Mesangial IgA Glomerulonephritis: An Extensive Study With Univariate and Multivariate Analyses","volume":"18","author":"E Alamartine","year":"1991","journal-title":"Am J Kidney Dis"},{"key":"pone.0301853.ref003","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0272-6386(88)80023-4","article-title":"Clinical features and natural history in adults with IgA nephropathy","volume":"12","author":"G. 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