{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:36:43Z","timestamp":1775936203198,"version":"3.50.1"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Applied Biological Laboratories Inc"},{"name":"Applied Biological Laboratories"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Common cold viruses are leading triggers of asthma attacks, causing nearly two million hospitalizations per year and productivity losses approaching $40B. They also increase susceptibility to bacterial infections driving antibiotic use. Post-market clinical studies have questioned the efficacy of most over the counter (OTC) cough and cold ingredients against placebo in treating various symptoms. To our knowledge, only aspirin significantly improved overall illness severity compared to placebo and that was by about 25\u201330%. In this double-blind randomized placebo-controlled trial involving 157 participants, we sought to determine whether a throat spray containing a mucosal immune complex (MIC) (comprised of lysozyme, lactoferrin, and aloe) along with anti-inflammatory salicylates can increase the hereto reported efficacy of aspirin at reducing common cold symptoms. Previously published reports showed that the MIC can protect respiratory epithelia and lower inflammatory cytokines. Salicylates are naturally occurring plant compounds found in many common foods as well as wintergreen oil and are chemically similar precursors to aspirin (acetyl salicylate). Participants self-administered treatments (throat sprays every hour and tablets every four hours) and completed surveys at home over two days. Treatments included MIC spray mixed with 6 mg aspirin + placebo tablet (Treatment 1), MIC spray mixed with 6 mg wintergreen oil+ placebo tablet (Treatment 2), MIC spray mixed with 6mg wintergreen oil+ 325 mg aspirin tablet (Treatment 3). Participants included adult volunteers ages 21\u201366 (average 44), 54% female, 46% male, 46% African American, 8% Asian, 39% Caucasian, and 7% Hispanic, having common cold symptoms lasting less than two days. The main outcome measures included Sore Throat Pain Intensity (STPIS) 0\u2013100 at 36 hours (primary endpoint) and Modified Jackson Score (MJS), a combination of eight cold symptoms (secondary endpoint). Both primary and secondary endpoints were met. Sore throat pain as measured by STPIS decreased 68\u201375% by 36 hours depending on treatment. Other symptoms such as nasal discharge, congestion, sneezing, cough, sore throat, and malaise as measured by MJS decreased 38\u201368% depending on treatment. In repeated measure within group analysis observing the same participants over multiple time points; the mean change of STPIS values and their percentage change from baseline to 36 hours were as follows: Placebo (-7.84 [95% CI -14.20 to -1.47];(-14%)), Treatment 1 (-42.41 [95% CI -48.30 to -36.52];(-75%)), Treatment 2 (-38.60 [95% CI -46.64 to -31.56];(-68%)), and Treatment 3 (-44.19 [95% CI -52.11 to -36.27];(-79%)). In repeated measure within group analysis all treatments significantly reduced cold symptom severity (MJS) from Days 1\u20132. Results were as follows: Treatment 1 (-2.26 [95% CI -3.04 to -1.47] (-38%)), Treatment 2 (-3.81 [95% CI -4.82 to -2.80];(-53%)), Treatment 3 (-4.49 [95% CI -5.62 to -3.57];(-69%)). As a result of this study, we conclude that supporting upper respiratory epithelia and reducing COX-mediated inflammation may be used to effectively treat common cold symptoms.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration:<\/jats:bold>\n                    ClinicalTrials.gov Identifier:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT06106880?term=NCT06106880&amp;draw=2&amp;rank=1\" xlink:type=\"simple\">NCT06106880<\/jats:ext-link>\n                    Posted 30\/10\/2023.\n                  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Horak","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"pone.0301959.ref021","first-page":"CD004976","article-title":"Oral antihistamine-decongestant-analgesic combinations for the common cold.","volume":"1","author":"AI De Sutter","year":"2022","journal-title":"Cochrane Database Syst Rev."},{"issue":"5","key":"pone.0301959.ref022","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jaip.2015.05.007","article-title":"Oral Phenylephrine HCl for Nasal Congestion in Seasonal Allergic Rhinitis: A Randomized, Open-label, Placebo-controlled Study","volume":"3","author":"EO Meltzer","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"pone.0301959.ref023"},{"issue":"7","key":"pone.0301959.ref024","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.clinthera.2005.06.002","article-title":"Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging study.","volume":"27","author":"C Bachert","year":"2005","journal-title":"Clin Ther"},{"issue":"4","key":"pone.0301959.ref025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/194589240101500404","article-title":"The therapeutic effectiveness of ibuprofen on the symptoms of naturally acquired common colds.","volume":"15","author":"B Winther","year":"2001","journal-title":"Am J Rhinol"},{"issue":"10","key":"pone.0301959.ref026","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10654-021-00754-4","article-title":"Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts","volume":"36","author":"S Alemany","year":"2021","journal-title":"Eur J 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Journal"},{"issue":"7","key":"pone.0301959.ref030","first-page":"CD008800","article-title":"Acetaminophen (paracetamol) for the common cold in adults.","volume":"2013","author":"S Li","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"102","key":"pone.0301959.ref031","article-title":"Aspirin plus Vitamin C Provides Better Relief than Placebo in Managing the Symptoms of the Common Cold.","volume":"1","author":"A Sessa","year":"2017","journal-title":"J Health Care Prev."},{"issue":"5","key":"pone.0301959.ref032","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4049\/jimmunol.161.5.2509","article-title":"Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products","volume":"161","author":"L Pang","year":"1998","journal-title":"J Immunol"},{"issue":"3","key":"pone.0301959.ref033","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/ajrccm\/137.3.613","article-title":"Nasal provocation with bradykinin induces symptoms of rhinitis and a sore throat","volume":"137","author":"D Proud","year":"1988","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"pone.0301959.ref034","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/00016489409126062","article-title":"Sore throat following nasal and oropharyngeal bradykinin challenge.","volume":"114","author":"GL Rees","year":"1994","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"pone.0301959.ref035","doi-asserted-by":"crossref","first-page":"L612","DOI":"10.1152\/ajplung.00483.2001","article-title":"Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids","volume":"283","author":"HC Rodgers","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6 Pt 1","key":"pone.0301959.ref036","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0091-6749(05)80156-3","article-title":"Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy","volume":"86","author":"WJ Doyle","year":"1990","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"pone.0301959.ref037","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1172\/JCI13210","article-title":"Arachidonic acid as a bioactive molecule","volume":"107","author":"AR Brash","year":"2001","journal-title":"J Clin Invest"},{"issue":"10","key":"pone.0301959.ref038","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/eji.202048909","article-title":"Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions","volume":"51","author":"OO Oyesola","year":"2021","journal-title":"Eur J Immunol"},{"issue":"4","key":"pone.0301959.ref039","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/iid3.479","article-title":"A novel anti-inflammatory treatment for bradykinin-induced sore throat or pharyngitis.","volume":"9","author":"V Leyva-Grado","year":"2021","journal-title":"Immun Inflamm Dis"},{"issue":"14","key":"pone.0301959.ref040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144903","article-title":"Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation.","volume":"21","author":"E Campione","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pone.0301959.ref041","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.virol.2005.01.010","article-title":"Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate","volume":"333","author":"BL Waarts","year":"2005","journal-title":"Virology"},{"issue":"3","key":"pone.0301959.ref042","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0166-3542(01)00195-4","article-title":"Antiviral activities of lactoferrin","volume":"52","author":"BW van der Strate","year":"2001","journal-title":"Antiviral Res"},{"issue":"7","key":"pone.0301959.ref043","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0161-5890(03)00152-4","article-title":"Lactoferrin\u2014a multifunctional protein with antimicrobial properties","volume":"40","author":"S Farnaud","year":"2003","journal-title":"Mol Immunol"},{"issue":"36","key":"pone.0301959.ref044","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105815118","article-title":"Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19","volume":"118","author":"C Mirabelli","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"pone.0301959.ref045","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1096\/fj.07-098038","article-title":"Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells","volume":"22","author":"M Spadaro","year":"2008","journal-title":"FASEB J"},{"issue":"11","key":"pone.0301959.ref046","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jiac.2014.08.003","article-title":"Lactoferrin for prevention of common viral infections.","volume":"20","author":"H Wakabayashi","year":"2014","journal-title":"J Infect Chemother"},{"issue":"4660","key":"pone.0301959.ref047","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/183548a0","article-title":"Antiviral activity of lysozyme","volume":"183","author":"R Ferrari","year":"1959","journal-title":"Nature"},{"issue":"4","key":"pone.0301959.ref048","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1755-3768.1991.tb02034.x","article-title":"Tear lysozyme levels in bacterial, fungal and viral corneal ulcers.","volume":"69","author":"H Lal","year":"1991","journal-title":"Acta Ophthalmol (Copenh)."},{"issue":"11","key":"pone.0301959.ref049","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1097\/MLG.0b013e31812e01ab","article-title":"Nasal mucosa expression of lactoferrin in patients with chronic rhinosinusitis","volume":"117","author":"AJ Psaltis","year":"2007","journal-title":"Laryngoscope"},{"issue":"1","key":"pone.0301959.ref050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1145\/272991.272995","article-title":"Mersenne twister: A 623-dimensionally equidistributed uniform pseudo-random number generator","volume":"8","author":"M Matsumoto","year":"1998","journal-title":"ACM Transactions on Modeling and Computer Simulation"},{"key":"pone.0301959.ref051","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/1745-6215-15-263","article-title":"Utility of the sore throat pain model in a multiple-dose assessment of the acute analgesic flurbiprofen: a randomized controlled study","volume":"15","author":"B Schachtel","year":"2014","journal-title":"Trials"},{"key":"pone.0301959.ref052","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1477-7525-7-76","article-title":"Validation of a short form Wisconsin Upper Respiratory Symptom Survey (WURSS-21).","volume":"7","author":"B Barrett","year":"2009","journal-title":"Health Qual Life Outcomes"},{"issue":"6","key":"pone.0301959.ref053","doi-asserted-by":"crossref","first-page":"e028098","DOI":"10.1136\/bmjopen-2018-028098","article-title":"Protocol for a randomised, single-blind, two-arm, parallel-group controlled trial of the efficacy of rhinothermy delivered by nasal high flow therapy in the treatment of the common cold","volume":"9","author":"G Bird","year":"2019","journal-title":"BMJ Open"},{"issue":"7","key":"pone.0301959.ref054","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1089\/ars.2012.5164","article-title":"Inflammation, DAMPs, tumor development, and progression: a vicious circle orchestrated by redox signaling","volume":"20","author":"P Castellani","year":"2014","journal-title":"Antioxid Redox 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