{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:21:15Z","timestamp":1793575275977,"version":"4.5.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjective<\/jats:title>\nTo evaluate daily physical activity (PA) in relation to psychosocial factors, such as anxiety, depression and different types of coping strategies, as well as patient- and disease-related factors in patients with axial spondyloarthritis (axSpA).<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nConsecutive outpatients from the Groningen Leeuwarden AxSpA (GLAS) cohort completed the modified Short Questionnaire to assess health-enhancing PA (mSQUASH), Hospital Anxiety and Depression Scale (HADS) and Coping with Rheumatic Stressors (CORS) questionnaires, as well as standardized patient- and disease-related assessments. Univariable and multivariable linear regression analyses and comparison of lowest and highest PA tertiles were performed to explore associations between the HADS, CORS, patient- and disease-related factors and PA.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nIn total, 84 axSpA patients were included; 60% male, mean age 49 (SD \u00b114) years, median symptom duration 20 (25th<\/jats:sup>-75th<\/jats:sup> percentiles: 12\u201331) years, mean ASDAS 2.1 (\u00b11.0). Higher PA levels were significantly associated with better scores on patient-reported disease activity (BASDAI), physical function (BASFI) and quality of life (ASQoL). Furthermore, higher levels of PA were associated with less impact of axSpA on wellbeing and lower HADS depression scores. In the multivariable linear regression model, less use of the coping strategy \u2018decreasing activities\u2019 (\u03b2: -376.4; p 0.003) and lower BMI (\u03b2:-235.5; p: 0.030) were independently associated with higher level of PA. Comparison of patients from the lowest and highest PA tertiles showed results similar to those found in the regression analyses.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nIn this cohort of axSpA patients, higher levels of daily PA were associated with better patient-reported outcomes and lower depression scores. Additionally, the passive coping strategy \u201cdecreasing activities\u201d and lifestyle factor BMI were independently associated with PA. Besides anti-inflammatory treatment, coping strategies and lifestyle should be taken into account in the management of individual axSpA patients. Incorporating these aspects into patient education could increase patient awareness and self-efficacy. In the future, longitudinal studies are needed to better understand the complex relationship between patient-, disease- and psychosocial factors associated with daily PA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0301965","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T18:21:23Z","timestamp":1715970083000},"page":"e0301965","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Higher levels of physical activity are associated with less evasive coping, better physical function and quality of life in patients with axial 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