{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:40:25Z","timestamp":1793850025429,"version":"4.6.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>This study aims to explore the applicability of narrow-band imaging (NBI) involving the Ni classification for the diagnosis of nasopharyngeal mucosal lesions in order to distinguish malignant tumours (NPT) from non-malignant lesions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Each patient (n = 53) with a suspected nasopharyngeal lesion underwent a trans-nasal flexible video endoscopy with an optical filter for NBI. We assessed the suspected area using white light imaging (WLI) in terms of location and morphology as well as the vascular pattern (using Ni classification of nasopharyngeal microvessels) and surrounding tissue by using NBI. Based on the results of the NBI and WLI, patients were classified into \"positive\" or \"negative\" groups. All lesions of the nasopharynx were biopsied and submitted for final histological evaluation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>NBI showed higher sensitivity, specificity, and accuracy than WLI. There was a significant correlation between the final histological result and the NBI pattern of the NPT: Chi<jats:sup>2<\/jats:sup>(1) = 31.34; p = 0.000001 and the WLI assessment of the NPT: Chi<jats:sup>2<\/jats:sup>(1) = 14.78; p = 0.00012.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The assessment of the NPT in NBI using Ni NBI classification proved valuable in suspected mucosa assessment. NBI not only confirms the suspicious areas in WLI, but it also shows microlesions beyond the scope of WLI and allows for proper sampling.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0302043","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:59:04Z","timestamp":1718647144000},"page":"e0302043","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The usefulness of narrow-band Imaging (NBI) in nasopharyngeal lesions\u2014Validation of the Ni NBI classification dedicated for vascular pattern in the nasopharynx"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-9040","authenticated-orcid":true,"given":"Hanna","family":"Klimza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Ma\u0107kowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacper","family":"Zagaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jackowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Banaszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wierzbicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"issue":"1","key":"pone.0302043.ref001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00405-016-4244-6","article-title":"The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia.","volume":"274","author":"L Stan\u00edkov\u00e1","journal-title":"Eur Arch Otorhinolaryngol. 2017 Jan"},{"issue":"2","key":"pone.0302043.ref002","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5009\/gnl.2013.7.2.258","article-title":"Magnifying endoscopy for intestinal follicular lymphoma is helpful for prompt diagnosis","volume":"7","author":"M Iwamuro","year":"2013","journal-title":"Gut Liver"},{"issue":"4","key":"pone.0302043.ref003","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4253\/wjge.v4.i4.151","article-title":"A case of gastric mucosa-associated lymphoid tissue lymphoma in which magnified endoscopy with narrow band imaging was useful in the diagnosis.","volume":"4","author":"K Nonaka","year":"2012","journal-title":"World J Gastrointest Endosc."},{"issue":"9","key":"pone.0302043.ref004","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00405-010-1236-9","article-title":"Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and\/or radiotherapy.","volume":"267","author":"C Piazza","year":"2010","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"7","key":"pone.0302043.ref005","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s00405-008-0835-1","article-title":"The value of narrow band imaging for early detection of laryngeal cancer","volume":"266","author":"A Watanabe","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"6","key":"pone.0302043.ref006","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00405-011-1516-z","article-title":"Pharyngo-laryngeal examination with the narrow band imaging technology: early experience.","volume":"268","author":"H Irjala","year":"2011","journal-title":"Eur Arch Otorhinolaryngol."},{"issue":"13","key":"pone.0302043.ref007","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.3390\/cancers13133273","article-title":"Vocal Fold Leukoplakia: Which of the Classifications of White Light and Narrow Band Imaging Most Accurately Predicts Laryngeal Cancer Transformation? 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