{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:56:06Z","timestamp":1783680966829,"version":"3.55.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"crossref","award":["2017\/1799"],"award-info":[{"award-number":["2017\/1799"]}],"id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Benzodiazepines (BZDs) are drugs commonly used for treating insomnia and anxiety. Although they are known to induce cognitive and psychomotor impairments, their effect on the risk of causing accidents at work remains understudied. The objective of this study is to estimate this risk by differentiating between the recommended use and overuse of these drugs (i.e., uninterrupted use for four months). The data come from the French National Health Data System, which provide a population composed of French people who had at least one work accident (WA) from 2017 to 2019 (approximately 2.5 million people). A linear probability model with two-way fixed effects is used to deal with time-constant heterogeneity and the time effect independent of individuals. The results show a reduction in the risk of WA after a short period of BZD use (one month) compared with no use at all, but the risk of WA increases when treatment exceeds the recommended duration. The intensity of use results in a greater risk of WAs: a 1% increase in BZD use (expressed as the amount reimbursed) leads to a 4.4% (p&lt;0.001) increase in the monthly risk of WAs. Moreover, we see an increase in risk in the month following the treatment discontinuation (+3.6%, p&lt;0.001), which could be due to rebounding and catch-up effects. Health professionals and BZD users should be made aware of the WA risk induced by the use of BZDs, particularly after prolonged use and after discontinuation of treatment. This study provides more evidence for the need to limit the duration of BZD treatment.<\/jats:p>","DOI":"10.1371\/journal.pone.0302205","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T18:13:50Z","timestamp":1713291230000},"page":"e0302205","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of benzodiazepine use on the risk of occupational accidents"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-5122","authenticated-orcid":true,"given":"Fran\u00e7ois-Olivier","family":"Baudot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"pone.0302205.ref001","author":"European Commission","year":"2021","journal-title":"COMMUNICATION FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT, THE COUNCIL, THE EUROPEAN ECONOMIC AND SOCIAL COMMITTEE AND THE COMMITTEE OF THE REGIONS EU strategic framework on health and safety at work 2021\u20132027 Occupational safety and health in a changing world of work [Internet]."},{"key":"pone.0302205.ref002","volume-title":"WHO\/ILO joint estimates of the work-related burden of disease and injury, 2000\u20132016: global monitoring report [Internet].","author":"WHO-ILO","year":"2021"},{"key":"pone.0302205.ref003","author":"EU-OSHA","year":"2017","journal-title":"An international comparison of the cost of work-related accidents and illnesses [Internet]."},{"key":"pone.0302205.ref004","author":"CNAM","year":"2019","journal-title":"Rapport annuel 2018\u2014L\u2019Assurance Maladie\u2014Risques professionnels [Internet]."},{"key":"pone.0302205.ref005","author":"Minist\u00e8re du Travail","year":"2021","journal-title":"4e Plan sant\u00e9 au travail [Internet]."},{"issue":"1","key":"pone.0302205.ref006","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1467-6419.2011.00699.x","article-title":"The Economics of Health and Safety at Work: An Interdiciplinary Review of the Theory and Policy.","volume":"27","author":"K Pouliakas","year":"2013","journal-title":"J Econ Surv"},{"key":"pone.0302205.ref007","volume-title":"The role of health problems and drug treatments in accidental injury at work [Internet].","author":"KT Palmer","year":"2016"},{"issue":"1","key":"pone.0302205.ref008","first-page":"157","article-title":"La survenue du cancer: effets de court et moyen termes sur l\u2019emploi, le ch\u00f4mage et les arr\u00eats maladie.","volume":"475","author":"T Barnay","year":"2015","journal-title":"Econ Stat."},{"key":"pone.0302205.ref009","author":"ANSM","year":"2017","journal-title":"Etat des lieux de la consommation des benzodiaz\u00e9pines [Internet]."},{"key":"pone.0302205.ref010","author":"HAS","year":"2018","journal-title":"Quelle place pour les benzodiaz\u00e9pines dans l\u2019anxi\u00e9t\u00e9? 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