{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:02:26Z","timestamp":1787022146657,"version":"build-2736575974"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    <jats:italic>Seriphidium herba-alba (Asso)<\/jats:italic>\n                    , a plant celebrated for its therapeutic qualities, is widely used in traditional medicinal practices throughout the Middle East and North Africa. In a detailed study of\n                    <jats:italic>Seriphidium herba-alba<\/jats:italic>\n                    (Asso), essential oils and extracts were analyzed for their chemical composition and antimicrobial properties. The essential oil, characterized using mass spectrometry and retention index methods, revealed a complex blend of 52 compounds, with santolina alcohol, \u03b1-thujone, \u03b2-thujone, and chrysanthenone as major constituents. Extraction yields varied significantly, depending on the plant part and method used; notably, methanol soaking of aerial parts yielded the most extract at 17.75%. The antimicrobial analysis showed that the extracts had selective antibacterial activity, particularly against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , and broad-spectrum antifungal activity against organisms such as\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus spp<\/jats:italic>\n                    . The methanol-soaked extract demonstrated the strongest antimicrobial properties, indicating its potential as a natural antimicrobial source. This study not only underscores the therapeutic potential of\n                    <jats:italic>Seriphidium herba-alba<\/jats:italic>\n                    (Asso) in pharmaceutical applications but also sets a foundation for future research focused on isolating specific bioactive compounds and in vivo testing.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0302329","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T13:25:35Z","timestamp":1714051535000},"page":"e0302329","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Seriphidium herba-alba (Asso): A comprehensive study of essential oils, extracts, and their antimicrobial properties"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-0732","authenticated-orcid":true,"given":"Hazem","family":"Aqel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husni","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"issue":"2","key":"pone.0302329.ref001","first-page":"225","article-title":"A study of acute dermal toxicity of Artemisia herba-alba Asso essential oils","volume":"12","author":"A Boukhennoufa","year":"2021","journal-title":"Indian J Nat Prod Resour"},{"issue":"2","key":"pone.0302329.ref002","first-page":"24","article-title":"Antimicrobial Properties and Physical Characteristics of Essential Oil Extracted from Seriphidium herba-alba (Asso) Collected in El Bayadh, Algeria.","volume":"5","author":"MM 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